Neural Aspects of Tinnitus

耳鸣的神经方面

• 批准号: 7564695
• 负责人: RICHARD J SALVI
• 金额: $ 33.68万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7564695
• 关键词: Acoustics; Affect; Agonist; American; Aminobutyric Acids; Animal Model; Animals; Auditory; Auditory area; Auditory system; Behavioral; Behavioral Model; Biological; Brain; Brain imaging; Butyric Acids; Chronic; Dose; Effectiveness; Elderly; Electrodes; GABA Agonists; Generations; Goals; Human; Implant; Individual; Measures; Noise; Noise Induced Tinnitus; Output; Pattern; Peripheral; Pharmaceutical Preparations; Pharmacotherapy; Polydipsia; Positron-Emission Tomography; Potassium Channel; Potassium Channel Blockers; Rattus; Recovery; Role; Schedule; Site; Subjective Tinnitus; System; Techniques; Testing; Time; Tinnitus; Up-Regulation; Vigabatrin; Yang; awake; behavior measurement; comparative efficacy; conditioning; design; drug development; gamma-Aminobutyric Acid; insight; neural patterning; neurophysiology; prepulse inhibition; relating to nervous system; research study; salicylate; sound

DESCRIPTION (provided by applicant): The overall goals of this project are to (1) obtain behavioral estimates of tinnitus induced by salicylate and acoustic overstimulation and measure the time course and the pitch of the tinnitus in individual animals, (2) identify the changes in neural activity (single unit activity, local field potentials) in the auditory cortex of awake rats using16 channel recording electrodes and (3) determine how the time course and pattern of neural activity correlate with behavioral measures of the pitch and time course of tinnitus, (4) determine if the behavioral and neurophysiological measures of salicylate induced tinnitus and noise-induced tinnitus can be suppressed by NS1883, a potassium channel agonist that has shown promise in suppressing salicylate-induced tinnitus. Two behavioral techniques, SIPAC and GPIAS, will be used to independently confirm the time course and pitch of the tinnitus. Spontaneous and sound evoked neural activity will be assessed in awake animals using chronically implanted 16-channel electrode arrays. The project will significantly advance our understanding of the time course and pitch of noise and drug induced tinnitus in an animal model, aid in identifying the key neurophysiological changes in the auditory cortex that are associated with tinnitus, and evaluate the effectiveness of a potassium channel agonist in suppressing salicylate and noise-induced tinnitus.

描述（由申请人提供）：该项目的总体目标是（1）获得水杨酸盐和声音过度刺激引起的耳鸣的行为估计，并测量个体动物耳鸣的时间过程和音调，（2）使用16通道记录电极识别清醒大鼠听觉皮层神经活动（单个单元活动，局部场电位）的变化，以及（3）确定耳鸣的时间过程和模式如何变化。 神经活动与耳鸣的音调和时程的行为测量相关，(4) 确定水杨酸盐诱发的耳鸣和噪音诱发的耳鸣的行为和神经生理学测量是否可以被 NS1883 抑制，NS1883 是一种钾通道激动剂，在抑制水杨酸盐诱发的耳鸣方面已显示出前景。 SIPAC 和 GPIAS 两种行为技术将用于独立确认耳鸣的时间进程和音高。将使用长期植入的 16 通道电极阵列在清醒的动物中评估自发和声音诱发的神经活动。该项目将显着增进我们对动物模型中噪声和药物引起的耳鸣的时间过程和音调的理解，帮助识别与耳鸣相关的听觉皮层的关键神经生理变化，并评估钾通道激动剂在抑制水杨酸盐和噪声引起的耳鸣方面的有效性。