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Assessment of tDCS-Induced Neuronal Responses with Advanced MRI

使用先进 MRI 评估 tDCS 诱导的神经元反应

基本信息

批准号：
9769093
负责人：
Leigh Charvet
金额：
$ 21.19万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-01 至 2021-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9769093
关键词：
Affect Aftercare Anodes Behavior Biological Markers Brain Brain region Cells Cerebrum Clinical Cognitive Data Devices Disease Disease Progression Dose Equipment Fatigue Frequencies Functional Magnetic Resonance Imaging Goals Home environment Human Image Impaired cognition Intervention Knowledge Left Magnetic Resonance Imaging Measurement Measures Membrane Metabolic Metabolism Methods Monitor Motor Multiple Sclerosis Nerve Degeneration Neurocognitive Neuronal Plasticity Neurons Organ Outcome Outcome Measure Oxygen Pathologic Patients Physiological Physiology Prefrontal Cortex Recovery Relaxation Research Residual state Rest Secondary Progressive Multiple Sclerosis Stimulus Symptoms Techniques Telemedicine Testing Therapeutic Therapeutic Effect Time Treatment Cost Treatment Efficacy Visit Work base behavioral outcome cognitive enhancement disability disabling symptom improved in vivo indexing innovation metabolic rate multiple sclerosis patient neuroimaging marker neuronal metabolism novel potential biomarker prevent reduce symptoms relating to nervous system research clinical testing response restoration symptom management telerehabilitation tool treatment effect treatment response

项目摘要

Project Summary/Abstract Transcranial direct current stimulation (tDCS) is a safe, well-tolerated and low-cost treatment approach and has shown effective therapeutic effects in managing symptoms and to enhancing recovery in patients with multiple sclerosis (MS). Despite positive clinical findings, the underlying mechanism of tDCS remains largely unclear. There is a current gap of knowledge of how and whether externally-applied tDCS modifies neural activity and oxygen metabolism in MS, as well as how and whether alleviated symptoms of MS due to tDCS correlate with neuronal metabolic changes. The proposed project will use advanced MRI techniques to test immediate (by simultaneous MRI), cumulative (at the end of 30 tDCS treatment sessions), and lingering (3 months after treatment) effects of tDCS on neuronal metabolism (e.g., cerebral metabolic rate of oxygen or CMRO2) in patients with secondary progressive MS (SPMS). Further, tDCS can be used as a challenge known to increase neural activity measured with CMRO2 using MRI as a physiological maneuver to examine the brain reserves or plasticity, through which we will develop biomarker of neuronal reactivity (NR) (i.e., percent increase of CMRO2) induced by the current stimulation. Additionally, we will correlate the tDCS modulation of brain network connectivity measured with resting state functional MRI and clinical improvement. The specific aims of the project are 1) To compare CMRO2 levels during sham, simultaneous tDCS and immediately after stimulation on baseline MR and at the end of 30 home-based tDCS sessions in patients with SPMS; 2) To determine the brain network connectivity changes between baseline and after 30 sessions home-based tDCS modulation; 3) To assess the relationship between the baseline NR (i.e., percent increase of CMRO2), ∆NR (change from baseline to 30 home-based sessions), connectivity measures, and behavioral outcome measures (fatigue and neurocognitive function) assessed at each MRI visit and 3 months after tDCS treatment. Such information is critical in providing objective and direct neuronal biophysiological evidence of tDCS modulation, with a strong potential to guide and interpret how tDCS interventions can slow down or prevent disease progression in these patients.

项目总结/摘要经颅直流电刺激（tDCS）是一种安全、耐受性好且成本低的治疗方法，在控制症状和促进患者康复方面显示出有效的治疗效果，多发性硬化症（MS）。尽管有积极的临床研究结果，但tDCS的潜在机制在很大程度上仍然是未知的。不清楚目前，关于外部应用tDCS如何以及是否改变神经功能的知识存在空白。 MS中的活性和氧代谢，以及如何以及是否减轻了由于tDCS引起的MS症状与神经元代谢变化相关。拟议的项目将使用先进的MRI技术来测试即刻（通过同步MRI）、累积（在30次tDCS治疗结束时）和延迟（3 治疗后6个月）tDCS对神经元代谢的影响（例如，大脑氧代谢率或 CMRO 2）在继发性进展性MS（SPMS）患者中的作用。此外，tDCS可以用作已知的挑战。使用MRI作为检查大脑的生理动作，增加CMRO 2测量的神经活动储备或可塑性，通过它我们将开发神经元反应性（NR）的生物标志物（即，百分 CMRO 2的增加）。此外，我们将关联的tDCS调制通过静息状态功能性MRI和临床改善测量脑网络连接。具体该项目的目的是1）比较假手术、同时tDCS期间和术后即刻的CMRO 2水平在基线MR和SPMS患者30次家庭tDCS治疗结束时进行刺激; 2）确定基线和30次家庭tDCS治疗后的脑网络连接变化调节; 3）评估基线NR（即，CMRO增加百分比2），CMNR （从基线到30次家庭治疗的变化）、连接测量和行为结果测量在每次MRI访视和tDCS治疗后3个月评估疲劳和神经认知功能。等信息对于提供tDCS调节的客观和直接的神经元生物生理学证据是至关重要的，具有指导和解释tDCS干预如何减缓或预防疾病的强大潜力这些患者的病情进展。