Neurogenetic analysis of value-based decision making
基于价值的决策的神经遗传学分析
基本信息
- 批准号:9769082
- 负责人:
- 金额:$ 44.8万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-08-23 至 2022-06-30
- 项目状态:已结题
- 来源:
- 关键词:AblationAdherenceAfferent NeuronsAgingAnimal ModelAnimalsBacteriaBehaviorBehavioralBiologicalBiological ModelsBrain InjuriesCaenorhabditis elegansCognitive deficitsComorbidityComplexComputer SimulationDataDecision MakingDiseaseDrosophila genusEatingEconomicsEtiologyFeedsFoodFood PreferencesFoundationsGenesGeneticGenetic EpistasisGenetic ModelsHeadHead MovementsHealthHumanIndividualInterneuronsInvertebratesInvestigationLaboratoriesLearningLinkLocomotionMathematicsMeasuresMental disordersMethodsMicrofluidic MicrochipsModelingMotor NeuronsNematodaNeurodegenerative DisordersNeuronsNumerical valueNutritionalOpticsOrganismOrthologous GenePartner in relationshipPathway interactionsPensionsPersonalityPersonsPhaseProceduresPropertyResearchResolutionRoleSideSmell PerceptionSocietiesSourceSpecific qualifier valueSuggestionSumSynapsesTestingTwin StudiesVertebratesWeightWorkaddictionbasebiological systemscostfeedingfitnessfood qualitygene functiongene interactiongenetic analysisgenome wide association studyinterestmanmathematical modelneural circuitneurogeneticsneurophysiologynovelpreferencepresynaptic neuronsresponsetraitwelfare
项目摘要
Project Summary
Dysfunctional decision making can have devastating impacts on individuals and on society. Many types
of decision making are therefore under vigorous investigation. This proposal emphasizes value-based deci-
sions, in which the chooser selects among options based on his subjective assessment of their value. A
deeper understanding of this behavior is needed to develop the best possible treatments for decision making
disorders, including the many forms of addiction and the cognitive deficits that accompany mental illness, brain
injury, and neurodegenerative disease.
Consumer choice is one of the best studied forms of value-based decisions. Studies reveal that our
economic personalities have a significant genetic basis, but it is difficult to trace causal links between genes
and behavior in humans. In response, geneticists often turn to simpler invertebrate organisms like the nema-
tode worm C. elegans in which the functions of genes nearly identical to their human equivalents can be inves-
tigated more rapidly, completely, and at a fraction of the cost. Until now, evidence that nematodes are truly ca-
pable of value-based decision making has merely been suggestive. However, economists have developed
mathematically rigorous testing procedures for determining whether decisions are based on subjective value.
The PI's laboratory has developed microfluidic devices that enable this test to be done on nematodes deciding
between high-quality food that is relatively abundant and low-quality food that is more scarce. The results meet
all the criteria of value-based decision making.
Previous work has identified a circuit of sensory neurons, interneurons, and motor neurons that controls
head movements as the worm makes decisions about which food to eat. Using a combination of functional im-
aging (Aim 1), optical manipulation of neuronal activity (Aim 2), and neuronal ablations (Aim 3), the proposed
research will identify contribution each neuron makes to value-based decisions. A central question is how food
value and abundance are represented in the circuit and how this representation is read-out in behavior. Aim 4
constructs a mathematical model based on data from Aim 1 and tests it using data from Aims 2 and 3.
Successful completion of the proposed research yields a biologically realistic computational model of
the neuronal mechanism of value-based decision making in a compact circuit than can, in principle, be under-
stood completely. This work provides a foundation for understanding value-based decisions in more complex
circuits. The work also lays the cornerstone for genetic analyses, at single-neuron resolution, of orthologs of
human genes identified in association studies related to decision making. The research is broadly significant
because it establishes a new biological system in which to analyze at single-neuron resolution the interaction
of genes previously associated with decision making in humans, and to discover novel genetic pathways in-
volved in this behavior.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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SHAWN R LOCKERY其他文献
SHAWN R LOCKERY的其他文献
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{{ truncateString('SHAWN R LOCKERY', 18)}}的其他基金
Genetic analysis of effort discounting in C. elegans
线虫努力折扣的遗传分析
- 批准号:
10244629 - 财政年份:2021
- 资助金额:
$ 44.8万 - 项目类别:
Genetic analysis of effort discounting in C. elegans
线虫努力折扣的遗传分析
- 批准号:
10363756 - 财政年份:2021
- 资助金额:
$ 44.8万 - 项目类别:
Neurogenetic analysis of value-based decision making
基于价值的决策的神经遗传学分析
- 批准号:
10205097 - 财政年份:2018
- 资助金额:
$ 44.8万 - 项目类别:
Neurogenetic analysis of value-based decision making
基于价值的决策的神经遗传学分析
- 批准号:
9227202 - 财政年份:2016
- 资助金额:
$ 44.8万 - 项目类别:
Microfluidic screening devices for health-span extending drugs
用于延长健康寿命药物的微流体筛选装置
- 批准号:
8647832 - 财政年份:2014
- 资助金额:
$ 44.8万 - 项目类别:
Microfluidic devices for high-throughput anthelmintic screens
用于高通量驱虫筛选的微流体装置
- 批准号:
7830469 - 财政年份:2009
- 资助金额:
$ 44.8万 - 项目类别:
Microfluidic devices for high-throughput anthelmintic screens
用于高通量驱虫筛选的微流体装置
- 批准号:
7937008 - 财政年份:2009
- 资助金额:
$ 44.8万 - 项目类别:
Imaging neuronal activity with voltage-sensitive Green Fluorescent Protein
使用电压敏感绿色荧光蛋白对神经元活动进行成像
- 批准号:
7281607 - 财政年份:2003
- 资助金额:
$ 44.8万 - 项目类别:
Imaging neuronal activity with voltage-sensitive GFP
使用电压敏感 GFP 成像神经元活动
- 批准号:
6611666 - 财政年份:2003
- 资助金额:
$ 44.8万 - 项目类别:
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