Microfluidic screening devices for health-span extending drugs

用于延长健康寿命药物的微流体筛选装置

基本信息

  • 批准号:
    8647832
  • 负责人:
  • 金额:
    $ 15.84万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2014
  • 资助国家:
    美国
  • 起止时间:
    2014-02-01 至 2016-05-31
  • 项目状态:
    已结题

项目摘要

Aging, the progressive degeneration of body and mind, is a universal problem marked by a decline in tissue organization and function, and an increase in the likelihood of death. Progress in understanding the cellular and molecular basis of aging is rapidly accelerating, following the discovery that several well-known model organisms age in many of the same ways as humans. In addition to their contributions to our basic understanding of the biology of aging, these organisms are now being used to screen for compounds that extend not only lifespan, but also the quality of life in older individuals (health span). One of the most powerful model systems in aging and health span research is the microscopic nematode Caenorhabditis elegans, favored for its short lifespan (2-3 weeks), genetic tractability, and low cost. C. elegans research is currently undergoing rapid innovation as its small size is particularly compatible with microfluidics - the manipulation of fluids in channels with dimensions of tens of micrometers. The overall goal of the proposed research is to accelerate the discovery of compounds that extend health span through the development of a novel microfluidic device that is likely to enhance the throughput and resolution of health span screening in this key organism. The conventional method of health span screening in C. elegans currently faces three critical barriers: the absence of rigorously standardized growth conditions, the difficulty of making repeated measurements on identified individuals, and the challenge of high-throughput quantification of feeding behavior, one of the most reliable measures of health in the worm. The proposed research takes a head-on approach to these challenges by combining, into a single device, two previously established microfluidic technologies, one for long-term culture of large numbers of individually isolated worms, and one for making non-invasive electrical recordings of feeding behavior. Phase I of the proposed research seeks fundamental proof of concept for the combined device. Phase II of the project extends this work by automating health- span screens and increasing their throughput.
衰老,即身体和精神的逐渐退化,是一个以组织衰退为标志的普遍问题 组织和功能,以及死亡可能性的增加。细胞免疫学研究进展 衰老的分子基础正在迅速加速,继发现几个著名的模型, 生物体衰老的方式与人类有许多相同之处。除了他们对我们的基本贡献之外, 随着对衰老生物学的了解,这些生物体现在被用来筛选化合物, 不仅延长寿命,而且延长老年人的生活质量(健康寿命)。一个最 在衰老和健康寿命的研究中,一个强大的模型系统是一种微小的线虫--小杆线虫 elegans,因其寿命短(2-3周),遗传易处理性和低成本而受到青睐。C. elegans研究是 目前正在进行快速创新,因为它的小尺寸特别适合微流体- 在几十微米的通道中操纵流体。拟议的总体目标 研究的目的是通过开发一种新的药物来加速发现延长健康寿命的化合物。 一种新的微流体装置,可能会提高健康跨度筛选的通量和分辨率, 这个关键的有机体。采用传统的健康寿命筛选方法,对C。目前,Elegans面临三个 关键障碍:缺乏严格标准化的生长条件,难以重复 对已识别个体的测量,以及高通量定量摄食的挑战 这是衡量蠕虫健康状况最可靠的指标之一。这项拟议中的研究采取了正面的 通过将两个先前建立的微流体装置组合到单个装置中来解决这些挑战, 技术,一种用于长期培养大量单独分离的蠕虫,另一种用于制造 进食行为的非侵入性电子记录。第一阶段的拟议研究寻求基本的 组合器械的概念验证。该项目的第二阶段通过自动化健康- 跨屏幕并增加其吞吐量。

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Trehalose extends healthspan in C. elegans.
海藻糖可延长线虫的健康寿命。
  • DOI:
    10.17912/w2rp4b
  • 发表时间:
    2016
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Robinson,KristinJ;McCormick,Kathyrn
  • 通讯作者:
    McCormick,Kathyrn
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SHAWN R LOCKERY其他文献

SHAWN R LOCKERY的其他文献

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{{ truncateString('SHAWN R LOCKERY', 18)}}的其他基金

Genetic analysis of effort discounting in C. elegans
线虫努力折扣的遗传分析
  • 批准号:
    10244629
  • 财政年份:
    2021
  • 资助金额:
    $ 15.84万
  • 项目类别:
Genetic analysis of effort discounting in C. elegans
线虫努力折扣的遗传分析
  • 批准号:
    10363756
  • 财政年份:
    2021
  • 资助金额:
    $ 15.84万
  • 项目类别:
Neurogenetic analysis of value-based decision making
基于价值的决策的神经遗传学分析
  • 批准号:
    10205097
  • 财政年份:
    2018
  • 资助金额:
    $ 15.84万
  • 项目类别:
Neurogenetic analysis of value-based decision making
基于价值的决策的神经遗传学分析
  • 批准号:
    9769082
  • 财政年份:
    2018
  • 资助金额:
    $ 15.84万
  • 项目类别:
Neurogenetic analysis of value-based decision making
基于价值的决策的神经遗传学分析
  • 批准号:
    9227202
  • 财政年份:
    2016
  • 资助金额:
    $ 15.84万
  • 项目类别:
Systems Physiology Training Program
系统生理学培训计划
  • 批准号:
    7918611
  • 财政年份:
    2009
  • 资助金额:
    $ 15.84万
  • 项目类别:
Microfluidic devices for high-throughput anthelmintic screens
用于高通量驱虫筛选的微流体装置
  • 批准号:
    7830469
  • 财政年份:
    2009
  • 资助金额:
    $ 15.84万
  • 项目类别:
Microfluidic devices for high-throughput anthelmintic screens
用于高通量驱虫筛选的微流体装置
  • 批准号:
    7937008
  • 财政年份:
    2009
  • 资助金额:
    $ 15.84万
  • 项目类别:
Imaging neuronal activity with voltage-sensitive Green Fluorescent Protein
使用电压敏感绿色荧光蛋白对神经元活动进行成像
  • 批准号:
    7281607
  • 财政年份:
    2003
  • 资助金额:
    $ 15.84万
  • 项目类别:
Imaging neuronal activity with voltage-sensitive GFP
使用电压敏感 GFP 成像神经元活动
  • 批准号:
    6611666
  • 财政年份:
    2003
  • 资助金额:
    $ 15.84万
  • 项目类别:

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亚裔美国童年幸存者加速衰老的指标
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对投资撤资的非裔美国人社区的社区劣势、认知老化和阿尔茨海默病风险进行纵向调查
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    2022
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    $ 15.84万
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    2021
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    $ 15.84万
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