Microfluidic screening devices for health-span extending drugs
用于延长健康寿命药物的微流体筛选装置
基本信息
- 批准号:8647832
- 负责人:
- 金额:$ 15.84万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-02-01 至 2016-05-31
- 项目状态:已结题
- 来源:
- 关键词:AgeAgingAmericanAnimal ModelBehaviorBiologicalBiological AssayBiological ModelsBiology of AgingBiomedical EngineeringBusinessesCaenorhabditis elegansCessation of lifeDetectionDevelopmentDevicesDimensionsEnvironmentFaceFeeding behaviorsFrequenciesGeneticGoalsGrantGrowthHeadHealthHumanIndividualLaboratory ResearchLicensingLifeLiquid substanceLongevityLongitudinal StudiesMarketingMeasurementMeasuresMethodsMicrofluidic MicrochipsMicrofluidicsMicroscopicModelingMolecularMovementNematodaOptical MethodsOpticsOrganismPharmaceutical PreparationsPhasePopulation GeneticsPumpQuality of lifeResearchResearch ContractsResolutionServicesSignal TransductionSystemTechnologyTimeTissuesUnited States National Institutes of HealthWorkage effectagedbasebody-mindcostinnovationmembermovienew technologynovelpublic health relevanceresearch studyscreeningsealsuccess
项目摘要
Aging, the progressive degeneration of body and mind, is a universal problem marked by a decline in tissue
organization and function, and an increase in the likelihood of death. Progress in understanding the cellular
and molecular basis of aging is rapidly accelerating, following the discovery that several well-known model
organisms age in many of the same ways as humans. In addition to their contributions to our basic
understanding of the biology of aging, these organisms are now being used to screen for compounds that
extend not only lifespan, but also the quality of life in older individuals (health span). One of the most
powerful model systems in aging and health span research is the microscopic nematode Caenorhabditis
elegans, favored for its short lifespan (2-3 weeks), genetic tractability, and low cost. C. elegans research is
currently undergoing rapid innovation as its small size is particularly compatible with microfluidics - the
manipulation of fluids in channels with dimensions of tens of micrometers. The overall goal of the proposed
research is to accelerate the discovery of compounds that extend health span through the development of a
novel microfluidic device that is likely to enhance the throughput and resolution of health span screening in
this key organism. The conventional method of health span screening in C. elegans currently faces three
critical barriers: the absence of rigorously standardized growth conditions, the difficulty of making repeated
measurements on identified individuals, and the challenge of high-throughput quantification of feeding
behavior, one of the most reliable measures of health in the worm. The proposed research takes a head-on
approach to these challenges by combining, into a single device, two previously established microfluidic
technologies, one for long-term culture of large numbers of individually isolated worms, and one for making
non-invasive electrical recordings of feeding behavior. Phase I of the proposed research seeks fundamental
proof of concept for the combined device. Phase II of the project extends this work by automating health-
span screens and increasing their throughput.
衰老是身体和精神的逐渐退化,是一个以组织衰退为特征的普遍问题
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Trehalose extends healthspan in C. elegans.
海藻糖可延长线虫的健康寿命。
- DOI:10.17912/w2rp4b
- 发表时间:2016
- 期刊:
- 影响因子:0
- 作者:Robinson,KristinJ;McCormick,Kathyrn
- 通讯作者:McCormick,Kathyrn
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SHAWN R LOCKERY其他文献
SHAWN R LOCKERY的其他文献
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{{ truncateString('SHAWN R LOCKERY', 18)}}的其他基金
Genetic analysis of effort discounting in C. elegans
线虫努力折扣的遗传分析
- 批准号:
10244629 - 财政年份:2021
- 资助金额:
$ 15.84万 - 项目类别:
Genetic analysis of effort discounting in C. elegans
线虫努力折扣的遗传分析
- 批准号:
10363756 - 财政年份:2021
- 资助金额:
$ 15.84万 - 项目类别:
Neurogenetic analysis of value-based decision making
基于价值的决策的神经遗传学分析
- 批准号:
10205097 - 财政年份:2018
- 资助金额:
$ 15.84万 - 项目类别:
Neurogenetic analysis of value-based decision making
基于价值的决策的神经遗传学分析
- 批准号:
9769082 - 财政年份:2018
- 资助金额:
$ 15.84万 - 项目类别:
Neurogenetic analysis of value-based decision making
基于价值的决策的神经遗传学分析
- 批准号:
9227202 - 财政年份:2016
- 资助金额:
$ 15.84万 - 项目类别:
Microfluidic devices for high-throughput anthelmintic screens
用于高通量驱虫筛选的微流体装置
- 批准号:
7830469 - 财政年份:2009
- 资助金额:
$ 15.84万 - 项目类别:
Microfluidic devices for high-throughput anthelmintic screens
用于高通量驱虫筛选的微流体装置
- 批准号:
7937008 - 财政年份:2009
- 资助金额:
$ 15.84万 - 项目类别:
Imaging neuronal activity with voltage-sensitive Green Fluorescent Protein
使用电压敏感绿色荧光蛋白对神经元活动进行成像
- 批准号:
7281607 - 财政年份:2003
- 资助金额:
$ 15.84万 - 项目类别:
Imaging neuronal activity with voltage-sensitive GFP
使用电压敏感 GFP 成像神经元活动
- 批准号:
6611666 - 财政年份:2003
- 资助金额:
$ 15.84万 - 项目类别:
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