Microfluidic screening devices for health-span extending drugs

用于延长健康寿命药物的微流体筛选装置

基本信息

  • 批准号:
    8647832
  • 负责人:
  • 金额:
    $ 15.84万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2014
  • 资助国家:
    美国
  • 起止时间:
    2014-02-01 至 2016-05-31
  • 项目状态:
    已结题

项目摘要

Aging, the progressive degeneration of body and mind, is a universal problem marked by a decline in tissue organization and function, and an increase in the likelihood of death. Progress in understanding the cellular and molecular basis of aging is rapidly accelerating, following the discovery that several well-known model organisms age in many of the same ways as humans. In addition to their contributions to our basic understanding of the biology of aging, these organisms are now being used to screen for compounds that extend not only lifespan, but also the quality of life in older individuals (health span). One of the most powerful model systems in aging and health span research is the microscopic nematode Caenorhabditis elegans, favored for its short lifespan (2-3 weeks), genetic tractability, and low cost. C. elegans research is currently undergoing rapid innovation as its small size is particularly compatible with microfluidics - the manipulation of fluids in channels with dimensions of tens of micrometers. The overall goal of the proposed research is to accelerate the discovery of compounds that extend health span through the development of a novel microfluidic device that is likely to enhance the throughput and resolution of health span screening in this key organism. The conventional method of health span screening in C. elegans currently faces three critical barriers: the absence of rigorously standardized growth conditions, the difficulty of making repeated measurements on identified individuals, and the challenge of high-throughput quantification of feeding behavior, one of the most reliable measures of health in the worm. The proposed research takes a head-on approach to these challenges by combining, into a single device, two previously established microfluidic technologies, one for long-term culture of large numbers of individually isolated worms, and one for making non-invasive electrical recordings of feeding behavior. Phase I of the proposed research seeks fundamental proof of concept for the combined device. Phase II of the project extends this work by automating health- span screens and increasing their throughput.
衰老是身体和精神的逐渐退化,是一个以组织衰退为特征的普遍问题

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Trehalose extends healthspan in C. elegans.
海藻糖可延长线虫的健康寿命。
  • DOI:
    10.17912/w2rp4b
  • 发表时间:
    2016
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Robinson,KristinJ;McCormick,Kathyrn
  • 通讯作者:
    McCormick,Kathyrn
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

SHAWN R LOCKERY其他文献

SHAWN R LOCKERY的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('SHAWN R LOCKERY', 18)}}的其他基金

Genetic analysis of effort discounting in C. elegans
线虫努力折扣的遗传分析
  • 批准号:
    10244629
  • 财政年份:
    2021
  • 资助金额:
    $ 15.84万
  • 项目类别:
Genetic analysis of effort discounting in C. elegans
线虫努力折扣的遗传分析
  • 批准号:
    10363756
  • 财政年份:
    2021
  • 资助金额:
    $ 15.84万
  • 项目类别:
Neurogenetic analysis of value-based decision making
基于价值的决策的神经遗传学分析
  • 批准号:
    10205097
  • 财政年份:
    2018
  • 资助金额:
    $ 15.84万
  • 项目类别:
Neurogenetic analysis of value-based decision making
基于价值的决策的神经遗传学分析
  • 批准号:
    9769082
  • 财政年份:
    2018
  • 资助金额:
    $ 15.84万
  • 项目类别:
Neurogenetic analysis of value-based decision making
基于价值的决策的神经遗传学分析
  • 批准号:
    9227202
  • 财政年份:
    2016
  • 资助金额:
    $ 15.84万
  • 项目类别:
Systems Physiology Training Program
系统生理学培训计划
  • 批准号:
    7918611
  • 财政年份:
    2009
  • 资助金额:
    $ 15.84万
  • 项目类别:
Microfluidic devices for high-throughput anthelmintic screens
用于高通量驱虫筛选的微流体装置
  • 批准号:
    7830469
  • 财政年份:
    2009
  • 资助金额:
    $ 15.84万
  • 项目类别:
Microfluidic devices for high-throughput anthelmintic screens
用于高通量驱虫筛选的微流体装置
  • 批准号:
    7937008
  • 财政年份:
    2009
  • 资助金额:
    $ 15.84万
  • 项目类别:
Imaging neuronal activity with voltage-sensitive Green Fluorescent Protein
使用电压敏感绿色荧光蛋白对神经元活动进行成像
  • 批准号:
    7281607
  • 财政年份:
    2003
  • 资助金额:
    $ 15.84万
  • 项目类别:
Imaging neuronal activity with voltage-sensitive GFP
使用电压敏感 GFP 成像神经元活动
  • 批准号:
    6611666
  • 财政年份:
    2003
  • 资助金额:
    $ 15.84万
  • 项目类别:

相似海外基金

Indicators of Accelerated Aging in Asian American Childhood Survivors
亚裔美国童年幸存者加速衰老的指标
  • 批准号:
    10910604
  • 财政年份:
    2023
  • 资助金额:
    $ 15.84万
  • 项目类别:
Longitudinal Examination of Neighborhood Disadvantage, Cognitive Aging, and Alzheimer's Disease Risk in Disinvested, African American Neighborhoods
对投资撤资的非裔美国人社区的社区劣势、认知老化和阿尔茨海默病风险进行纵向调查
  • 批准号:
    10370185
  • 财政年份:
    2022
  • 资助金额:
    $ 15.84万
  • 项目类别:
50th Annual Meeting of the American Aging Association
美国老龄化协会第 50 届年会
  • 批准号:
    10468570
  • 财政年份:
    2022
  • 资助金额:
    $ 15.84万
  • 项目类别:
Longitudinal Examination of Neighborhood Disadvantage, Cognitive Aging, and Alzheimer's Disease Risk in Disinvested, African American Neighborhoods
对投资撤资的非裔美国人社区的社区劣势、认知老化和阿尔茨海默病风险进行纵向调查
  • 批准号:
    10565869
  • 财政年份:
    2022
  • 资助金额:
    $ 15.84万
  • 项目类别:
51st Annual Meeting of the American Aging Association
美国老龄化协会第 51 届年会
  • 批准号:
    10602831
  • 财政年份:
    2022
  • 资助金额:
    $ 15.84万
  • 项目类别:
Advancing Native American Diversity in Aging Research through Undergraduate Education (Native American ADAR)
通过本科教育促进美国原住民老龄化研究的多样性(美国原住民 ADAR)
  • 批准号:
    10460942
  • 财政年份:
    2021
  • 资助金额:
    $ 15.84万
  • 项目类别:
Advancing Native American Diversity in Aging Research through Undergraduate Education (Native American ADAR)
通过本科教育促进美国原住民老龄化研究的多样性(美国原住民 ADAR)
  • 批准号:
    10172529
  • 财政年份:
    2021
  • 资助金额:
    $ 15.84万
  • 项目类别:
Diversity Supplement to Psychosocial Stress due to COVID-19 and Vascular Aging in African-American Women
对非裔美国女性因 COVID-19 和血管老化造成的心理社会压力进行多样性补充
  • 批准号:
    10709289
  • 财政年份:
    2021
  • 资助金额:
    $ 15.84万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了