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Biological mechanisms of risk and resiliency in brain aging among ethnic minorities

少数民族大脑衰老风险和弹性的生物学机制

基本信息

批准号：
9768544
负责人：
ROBERT C. WELSH
金额：
$ 7.7万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-22 至 2022-09-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9768544
关键词：
Address Affect Age Aging Alzheimer&apos s Disease Area Biological Brain Brain imaging Caucasians Cerebrovascular Disorders Cities Cognition Cognitive Collaborations Communities DNA Methylation Data Dementia Diffusion Disease Elderly Epigenetic Process Exercise Foundations Funding Opportunities Future Genetic Goals Gold Habits Health Healthcare Hispanic Americans Hispanics Human Image Impaired cognition Intervention Laboratories Lead Life Expectancy Life Style Magnetic Resonance Imaging Measures Mexican Americans Minority Groups Minority Participation Neurodegenerative Disorders Older Population Participant Perfusion Persons Population Preventive Intervention Process Protocols documentation Research Research Personnel Risk Risk Factors Sodium Chloride Stroke Structure Techniques Trust United States United States National Institutes of Health Universities University resources Utah Work aging brain brain health connectome diabetes risk disorder risk ethnic minority population experience genetic analysis health care availability health disparity innovation low socioeconomic status member metropolitan minority communities minority health neuroimaging nutrition patient engagement pre-clinical recruit resilience social socioeconomics success tool

项目摘要

Abstract Minority health disparities have been well documented in the United States. These disparities exist in the domains of access to healthcare and participation in health research. Ethnic minorities in the United States also have increased risk of cardio- and cerebrovascular disease, stroke, and dementia. It is also known that lifestyle differences (such as exercise and nutrition habits), lower socioeconomic status, and diabetes are risk factors. With the increasing proportion of ethnic minorities in the United States, it is imperative to better understand disease processes that have historically been studied in Caucasian populations. The proportion of elderly that are Hispanic is expected to double, or even triple, in the coming decades. With an increasing population fraction, and increasing life expectancy, it is projected that upwards of a 6-fold increase in Alzheimer's disease will occur in Hispanics. Establishing the trust and partnership between Hispanic communities and world-class researchers is paramount to enable large-scale studies in order to diminish the disparity in minority health research. Our goal is to establish a collaborative foundation between the local minority communities and our research group at the University of Utah. This foundation will greatly facilitate ethnic minority participation in state-of-the-art genetic analysis, such as the newly developed technique of epigenetic aging, and advanced brain imaging research. Succeeding in this goal will allow us to begin to understand the specific risk and resiliency factors related to brain aging in the Hispanic community. The scope of the current project will establish a partnership between local Hispanic communities (approximately 75% Mexican-American) in the Salt Lake City region, neuroimaging researchers at the University of Utah, and collaborators at UCLA. The project will leverage existing university resources, such as the Community/Patient Engagement Studio, to bring the project team members, community stakeholders, and communities in an equal partnership to establish the foundation to perform state-of- the-art genetic and neuroimaging research. The project will synergistically work with local communities to reduce barriers for participation in research. Success of this project will open up avenues that will lead to large-scale studies utilizing cutting edge genetic (epigenetic aging), and neuroimaging techniques that have been applied in studies of Caucasians related to brain aging and Alzheimer's. Utilization of these advanced tools will allow for much-needed research into early signs of brain risk, as well as resiliency, in the Hispanic population. The derived engagement and recruitment strategies, along with these data will form the basis of a future, large-scale study to examine the Alzheimer's disease process in Hispanic-Americans.

摘要