Cortex Changes in Real/Imagined Movement in ALS

描述(申请人提供)：严重的身体残疾对一个人的生活有巨大的影响，无论它是由神经退行性疾病引起的，如肌萎缩侧索硬化症(ALS)、脑干中风或脊髓损伤。患有这些疾病的人可能会被有效地锁定，保留他们的认知能力，但除了可能是最基本的眼球运动外，无法进行任何运动。在这类残障人士中，有一种对“仅凭思考”就能操作的技术有着浓厚的兴趣。由于无法治愈导致他们残疾的特定疾病，这种被称为脑机接口(BCI)的技术是恢复功能的最佳选择。BCI可以用来操作通讯设备、轮椅或假肢。对于闭锁的人来说，这种技术可能是沟通和自我决定的唯一选择，而对于患有ALS的人来说，它将提供一种可取的替代控制方法，在其他功能能力恶化的情况下可能会保留下来。 脑机接口的运作将依赖于对自愿大脑活动的检测和处理，例如尝试或想象敲击手指或移动腿等动作的能力，这些大脑活动在导致残疾的情况下幸存下来。然而，肌萎缩侧索硬化症的进展对产生这种大脑活动的皮质区域的影响还不是很清楚。 这项拟议的研究将使用神经成像技术来绘制和纵向研究ALS患者的皮质区域，这些区域可以为BCI提供控制信号。使用功能磁共振成像(FMRI)结合几年来的一系列运动控制实验，我们将纵向绘制大脑激活模式图，以检查功能稳定性、萎缩和可塑性。通过使用最先进的医学成像技术，该项目将进一步了解肌萎缩侧索硬化症(ALS)，也就是俗称的“卢格里克病”，以及该疾病对人类大脑和中枢神经系统的影响。这些知识将有助于生物医学工程努力建立设备，使患有肌萎缩侧索硬化症的人能够直接用大脑控制计算机和辅助技术。

DESCRIPTION (provided by applicant): A severe physical disability has a dramatic impact on a person's life, whether it is caused by a neuro-degenerative disease such as amyotrophic lateral sclerosis (ALS), a brainstem stroke, or a spinal cord injury. Someone with these conditions may be effectively "locked-in," retaining their cognitive ability, but unable to perform any movement except possibly the most basic eye movements. Among people with such disabilities, there is a keen interest in technology that can be operated "just by thinking." Short of a cure for the particular condition causing their disability, technology of this type, called a brain-computer interface (BCI), is the best option for restoration of function. A BCI could be used to operate a communication device, wheelchair, or a prosthetic limb. For someone who is locked-in, such technology may offer the only option for communication and self-determination, while for someone with ALS, it would provide a desirable alternative method of control that could potentially be retained as other functional abilities deteriorate. Operation of a BCI would rely on detection and processing of voluntary brain activity such as the ability to attempt or imagine movements such as tapping a finger, or moving a leg, brain activity that survives the condition resulting in the disability. However, the affect of ALS progression on the cortical areas that produce this brain activity is not well understood. The proposed research will use neuro-imaging techniques to map and longitudinally study regions of cortex in persons with ALS that could provide controls signals for a BCI. Using functional magnetic resonance imaging (fMRI) in conjunction with a series of motor control experiments over a period of several years we will longitudinally map brain activation patterns to examine functional stability, atrophy and plasticity. By using state of the art medical imaging, this project will further the understanding of amyotrophic lateral sclerosis (ALS), also commonly known as "Lou Gehrig's Disease", and the disease's effect on the human brain and central nervous system. This knowledge will contribute to the biomedical engineering effort to build devices to allow people with ALS to directly control computers and assistive technologies with their brains.