Tufts BIRCWH Program

项目摘要 显然有必要增加妇女健康和卫生领域的优秀研究人员的数量 性别/性别差异，以更好地了解疾病的基本机制，并开发 解决不同性别的治疗效果的异质性。塔夫茨大学大楼跨学科 妇女健康研究职业(BIRCWH)学者计划寻求开发一个示范计划，以 招聘、选拔和培训初级教员，以开展性别/性别差异和临床研究的基础研究 关于妇女健康问题的卫生服务研究。塔夫茨BIRCWH计划的长期目标是 培养下一代研究性别/性别差异和妇女健康的领导者。这个 该计划将在初级教师培训后6年内为他们提供资金。我们将资助两种类型的学员，基础科学 学者和临床学者，已完成博士培训，但需要更深入的研究 跨学科研究培训。该计划将通过5项关键活动实现其目标，这些活动是为满足 每位学者的培训需求：1)跨学科指导团队，2)正式研究培训，包括 萨克勒生物医学研究生院的课程，3)跨学科研究研讨会，4)a 有指导的研究项目，以及5)发展拨款提案准备的技能。 塔夫茨BIRCWH计划将促进从基础科学到性/性别的所有阶段的翻译研究 与关注妇女护理中几个重要问题的临床和结果研究的差异： 在基本细胞机制上的性别差异，包括心血管性别差异，性别机制 精神药理效应和副作用、癌症转移、生物工程的差异 宫颈组织、生殖和新生儿基因组医学，对母亲的代际影响及其 妊娠期儿童抑郁的性别差异及物质使用的基本机制。 营养学和性别/性别差异，重点是性激素和性别的基础研究 心血管和代谢性疾病的其他性别差异以及针对营养问题的临床研究 补充剂，以及妇女的营养和疾病。 关于妇女健康和性别差异的临床结果和比较有效性研究， 主要关注心血管疾病、新陈代谢和营养。 了解性别和劳动力问题、健康对女性劳动力职能的影响，以及 性别和学术科学职业。 我们建议每年资助3名学者，初步任命为2年，并可考虑 第三年了。

Project Summary There is a demonstrated need to increase the number of excellent researchers in women's health and sex/gender differences to better understand basic mechanisms of disease and develop treatment that addresses the heterogeneity of treatment effects by sex. The Tufts University Building Interdisciplinary Research Careers in Women's Health (BIRCWH) Scholars Program seeks to develop a model program to recruit, select, and train junior faculty to conduct basic research in sex/gender differences and clinical and health services research on women's health issues. The long term goals of the Tufts BIRCWH Program are to develop the next generation of leaders in research in sex/gender differences and women’s health. The Program will fund junior faculty within 6 years of their training. We will fund 2 types of trainees, Basic Science Scholars and Clinical Scholars, who have completed their doctoral training but require more in depth interdisciplinary research training. The Program will achieve its goals through 5 key activities, tailored to meet each Scholar’s training needs: 1) interdisciplinary mentoring teams, 2) formal research training including courses at the Sackler School of Graduate Biomedical Sciences, 3) interdisciplinary research seminars, 4) a mentored research project, and 5) development of skills in grant proposal preparation. The Tufts BIRCWH Program will promote all stages of translational research from basic science in sex/gender differences to clinical and outcomes research focusing on several important questions in the care of women:  Sex differences in basic cellular mechanisms, including cardiovascular sex differences, mechanisms of sex differences in psychopharmacological effects and side effects, cancer metastases, bioengineering of cervical tissue, reproductive and neonatal genomic medicine, intergenerational effects on mothers and their children during pregnancy, basic mechanism of sex differences in depression and substance use.  Nutrition science and sex/gender differences, with a focus on both basic research on sex hormones and other sex differences in cardiovascular and metabolic diseases and clinical research addressing nutritional supplements, and nutrition and disease in women.  Clinical outcomes and comparative effectiveness research on women’s health and gender differences, with a major focus on cardiovascular disease, metabolism and nutrition.  Understanding gender and workforce issues, the impact of health on workforce functioning in women, and gender and academic science careers. We propose to fund 3 scholars annually, with initial appointments of 2 years with an option to be considered for a 3rd year.