Tufts BIRCWH Program

塔夫茨大学 BIRCWH 项目

• 批准号: 9368907
• 负责人: Karen Freund
• 金额: $ 53.84万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-11 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9368907
• 关键词: Address; Adverse effects; Alcohol or Other Drugs use; Applications Grants; Appointment; Basic Science; Biomedical Engineering; Cardiovascular Diseases; Cardiovascular system; Caring; Cervical; Child; Clinical; Clinical Research; Clinical Services; Disease; Faculty; Funding; Gender; Genomic medicine; Goals; Gonadal Steroid Hormones; Health; Health Services Research; Heterogeneity; Interdisciplinary Study; Mental Depression; Mentors; Metabolic Diseases; Metabolism; Modeling; Mothers; NCI Scholars Program; Neonatal; Neoplasm Metastasis; Nutritional Science; Outcome; Outcomes Research; Pregnancy; Preparation; Recruitment Activity; Research; Research Personnel; Research Project Grants; Research Training; Schools; Science; Sex Characteristics; Tissues; Training; Translational Research; Universities; Woman; Women' s Health; career; comparative effectiveness; dietary supplements; effectiveness research; gender difference; health difference; intergenerational; next generation; nutrition; programs; psychopharmacologic; reproductive; sex; skill acquisition; treatment effect

Project Summary There is a demonstrated need to increase the number of excellent researchers in women's health and sex/gender differences to better understand basic mechanisms of disease and develop treatment that addresses the heterogeneity of treatment effects by sex. The Tufts University Building Interdisciplinary Research Careers in Women's Health (BIRCWH) Scholars Program seeks to develop a model program to recruit, select, and train junior faculty to conduct basic research in sex/gender differences and clinical and health services research on women's health issues. The long term goals of the Tufts BIRCWH Program are to develop the next generation of leaders in research in sex/gender differences and women’s health. The Program will fund junior faculty within 6 years of their training. We will fund 2 types of trainees, Basic Science Scholars and Clinical Scholars, who have completed their doctoral training but require more in depth interdisciplinary research training. The Program will achieve its goals through 5 key activities, tailored to meet each Scholar’s training needs: 1) interdisciplinary mentoring teams, 2) formal research training including courses at the Sackler School of Graduate Biomedical Sciences, 3) interdisciplinary research seminars, 4) a mentored research project, and 5) development of skills in grant proposal preparation. The Tufts BIRCWH Program will promote all stages of translational research from basic science in sex/gender differences to clinical and outcomes research focusing on several important questions in the care of women:  Sex differences in basic cellular mechanisms, including cardiovascular sex differences, mechanisms of sex differences in psychopharmacological effects and side effects, cancer metastases, bioengineering of cervical tissue, reproductive and neonatal genomic medicine, intergenerational effects on mothers and their children during pregnancy, basic mechanism of sex differences in depression and substance use.  Nutrition science and sex/gender differences, with a focus on both basic research on sex hormones and other sex differences in cardiovascular and metabolic diseases and clinical research addressing nutritional supplements, and nutrition and disease in women.  Clinical outcomes and comparative effectiveness research on women’s health and gender differences, with a major focus on cardiovascular disease, metabolism and nutrition.  Understanding gender and workforce issues, the impact of health on workforce functioning in women, and gender and academic science careers. We propose to fund 3 scholars annually, with initial appointments of 2 years with an option to be considered for a 3rd year.

项目摘要 事实证明，需要增加妇女健康领域优秀研究人员的数量， 性别/性别差异，以更好地了解疾病的基本机制，并制定治疗方法， 讨论了不同性别治疗效果的异质性。塔夫茨大学建筑跨学科 妇女健康研究职业（BIRCWH）学者计划旨在制定一个示范计划， 招聘，选择和培训初级教师进行性/性别差异和临床和 关于妇女健康问题的保健服务研究。塔夫茨BIRCWH计划的长期目标是 培养下一代在性/性别差异和妇女健康研究方面的领导人。的 该计划将资助初级教师在6年内的培训。我们将资助两种类型的培训生，基础科学 学者和临床学者，他们已经完成了博士培训，但需要更深入的研究 跨学科研究培训。该计划将通过5项关键活动实现其目标，这些活动旨在满足 每个学者的培训需求：1）跨学科的指导团队，2）正式的研究培训，包括 萨克勒生物医学研究生院的课程，3）跨学科研究研讨会，4）a 指导的研究项目，和5）在赠款提案准备的技能发展。 塔夫茨BIRCWH计划将促进从性/性别基础科学的所有阶段的转化研究 与侧重于妇女护理中几个重要问题的临床和成果研究的差异： 基本细胞机制的性别差异，包括心血管性别差异，性别机制 精神药理学作用和副作用的差异，癌症转移， 子宫颈组织，生殖和新生儿基因组医学，对母亲的代际影响及其 妊娠期儿童抑郁和物质使用的性别差异的基本机制。 营养科学和性/性别差异，重点是性激素的基础研究， 心血管和代谢疾病的其他性别差异以及针对营养问题的临床研究 补充剂，营养和疾病的妇女。 关于妇女健康和性别差异的临床结果和比较有效性研究， 主要关注心血管疾病、代谢和营养。 了解性别和劳动力问题，健康对妇女劳动力功能的影响， 性别和学术科学事业。 我们建议每年资助3名学者，首次任命为2年，并可考虑选择 第三年。