Manipulating the balance of effector and regulatory T cells to promote islet xenograft survival

操纵效应T细胞和调节性T细胞的平衡以促进胰岛异种移植物的存活

• 批准号: nhmrc : 1061868
• 负责人: A/Pr Mark Nottle
• 金额: $ 102.86万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/manipulating-balance-effector-xenograft-survival/454938
• 关键词: Manipulating; balance; effector; regulatory; cells

Type 1 diabetes destroys the body’s insulin-producing cells (islets), resulting in high blood sugar levels and the prospect of devastating complications. Replacement of islets by transplantation is the only way to restore normal blood sugar control, but (i) is limited by the shortage of human donors and (ii) carries risks associated with anti-rejection drugs. This project aims to solve both problems by using humanized pigs as donors combined with a novel approach to inducing tolerance to the transplanted islets.

1 型糖尿病会破坏体内产生胰岛素的细胞（胰岛），导致高血糖并可能出现毁灭性并发症。通过移植替代胰岛是恢复正常血糖控制的唯一方法，但（i）受到人类捐赠者短缺的限制，并且（ii）存在与抗排斥药物相关的风险。该项目旨在通过使用人源化猪作为供体并结合诱导对移植胰岛的耐受性的新方法来解决这两个问题。