New strategies to protect pig-to-human renal xenografts

保护猪到人肾异种移植物的新策略

• 批准号: nhmrc : 1046152
• 负责人: A/Pr Mark Nottle
• 金额: $ 75.68万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/new-strategies-protect-renal-xenografts/111820
• 关键词: New; strategies; protect; pig; human

Kidney failure contributes to 11% of all deaths in Australia and is projected to affect as many as 30,000 Australians by 2020, at a cumulative cost of $12 billion. Kidney transplantation is a far more effective treatment for this condition than dialysis, but there will always be a shortfall of human donors. Using pigs as donors offers a potential solution. The aim of this project is to genetically modify donor pigs so that their kidneys will not be rejected by human recipients.

肾衰竭占澳大利亚所有死亡人数的11%，预计到2020年将影响多达30，000名澳大利亚人，累计成本为120亿美元。对于这种情况，肾移植是一种比透析更有效的治疗方法，但人类捐赠者总是短缺。利用猪作为供体提供了一个潜在的解决方案。该项目的目的是对捐赠的猪进行基因改造，使它们的肾脏不会被人类接受者排斥。