BLR&D Research Career Scientist Award Application

BLR

• 批准号: 9899091
• 负责人: Jie Fan
• 金额: --
• 依托单位: VETERANS HEALTH ADMINISTRATION
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9899091
• 关键词: Acute; Acute Lung Injury; Alveolar Macrophages; American; Animals; Area; Autoimmune Diseases; Award; Biological Sciences; Brain Injuries; Cause of Death; Cell Death; Cell Differentiation process; Cells; Cessation of life; Chronic; Collaborations; Communication; Development; Disease; Doctor of Medicine; Doctor of Philosophy; Faculty; Failure; Functional disorder; Funding; Goals; Government; Grant Review; Health; Healthcare; Healthcare Systems; Hemorrhage; Hemorrhagic Shock; Hepatology; Immunology; Infection; Inflammasome; Inflammation; Institution; Interleukin-1; International; Intervention; Journals; Laboratories; Literature; Mediating; Medical; Medicine; Mentors; Molecular; Natural Immunity; Nature; Operative Surgical Procedures; Organ; Pathogenesis; Patients; Peer Review; Peptides; Permeability; Phase; Physicians; Play; Population; Postdoctoral Fellow; Preventive Intervention; Principal Investigator; Publications; Research; Research Personnel; Research Project Grants; Review Committee; Role; Science; Scientist; Sepsis; Signal Pathway; Signal Transduction; Spinal Injuries; Stroke; Study Section; Systemic Inflammatory Response Syndrome; Therapeutic Intervention; Time; Toll-like receptors; Trauma; Trauma patient; United States National Institutes of Health; Universities; Veterans; Work; base; career; clinical investigation; cytokine; editorial; human disease; improved; institutional biosafety committee; member; mortality; multidisciplinary; new therapeutic target; novel; patient population; peer; post-trauma; prevent; programs; prophylactic; protein complex; senior faculty; surgical research; survival outcome; symposium; therapy development; visiting scholar

PROJECT SUMMARY Jie Fan, M.D., M.Sc. has been working in the VA Pittsburgh Healthcare System (VAPHS) since 2003, and is a Director of the Multidisciplinary Surgical Research Program, a Vice Chair of the Institutional Biosafety Committee in VAPHS, and a tenured Full Professor of the Department of Surgery at the University of Pittsburgh. He is a Principal Investigator working on the cellular and molecular mechanisms of sepsis, post-trauma systemic inflammatory response syndrome (SIRS) and acute lung injury (ALI), an important but exceptionally difficult area. His laboratory has been funded by two VA merit review grants and four NIH research grants (R01, P50, and R56). The burden of trauma-related diseases is considerable. Following exsanguination and/or brain injury that commonly result in early phase death, more than 60% of surviving patients later die of causes related to the development of SIRS, sepsis, and ALI. This patient population is well suited for prophylactic interventions aimed at preventing these occurrences because of the time lag before the onset of organ inflammation and failure. Nonetheless, few specific targets have been identified that predispose to SIRS and ALI. The long term goal of Dr. Fan’s studies is to provide a new understanding of the mechanisms of post-trauma inflammation and organ dysfunction, and therefore, to potentially provide novel targets for preventive and therapeutic interventions in post-trauma SIRS, sepsis, and ALI. The studies by Dr. Fan’s team will also provide a greater understanding of the pathogenesis of multiple human diseases in which inflammation plays a central role. ALI is one of the common endpoints of SIRS and sepsis. SIRS and sepsis are common causes of mortality following surgery, infection, spinal injury, stroke, hemorrhage, and trauma in the veteran population. And thus, Dr. Fan’s research is highly relevant to Veterans’ health. Dr. Fan’s research provides critical information that can be used toward the development of therapies for veterans with post-trauma inflammation and ALI. He is a highly productive Principal Investigator with a long track record of both VA and NIH funding. He has also served in roles such as Co-Investigator, Consultant, and Collaborator on numerous other research grants. His research and collaborations have resulted in 113 peer-reviewed publications, many of them in the best scientific journals and with high impact factors, including Nature Medicine, Nature Communications, Journal of Clinical Investigation, Hepatology, Journal of Hepatology, Cell Death & Differentiation, and Journal of Immunology. Dr. Fan’s work is renowned by his peers nationally and internationally. He has been an invited speaker at numerous national and international conferences and at many research and educational institutions. He serves as a reviewer in a number of national peer-review committees, including VA, NIH, DoD, and American Institution of Biological Sciences study sections. He also serves as editor-in-chief, member of editorial board, and invited reviewer for over 50 scientific journals. He has mentored 27 VA and non-VA trainees including Ph.D. candidates, postdoctoral fellows, residents, junior surgery faculties, and visiting scholars, many of whom have now become independent scientists or physician scientists. Dr. Fan is a 2010 recipient of the Excellence in Government Award for Outstanding Contribution to Medical Sciences.

项目摘要 Jie Fan，M.D.，M.Sc。由于 2003年，是多学科外科研究计划的主任，是该计划的副主席 VAPAS的机构生物安全委员会，以及终身的手术教授 在匹兹堡大学。他是在细胞和分子上工作的主要研究员 败血症，创伤后全身炎症综合征（SIRS）和急性肺的机制 受伤（ALI），这是一个重要但非常困难的领域。他的实验室由两个VA资助 绩效审查赠款和四项NIH研究补助金（R01，P50和R56）。 与创伤相关疾病的燃烧相当大。遵循解血和/或大脑 通常导致早期死亡的伤害，超过60％的尚存患者后来死亡 与Sir，败血症和Ali的发展有关的原因。这个患者群体非常适合 预防性干预措施旨在防止这种情况，因为 器官炎症和失败的发作。但是，很少有人确定 尊敬的先生和阿里。范博士研究的长期目标是提供新的理解 创伤后感染和器官功能障碍的机制，因此 提供新的靶标，用于在创伤后SIRS，败血症和Ali中进行预防和治疗性干预措施。 范博士团队的研究还将对多重发病机理有更深入的了解 炎症起着核心作用的人类疾病。 阿里是爵士和败血症的常见终点之一。先生和败血症是 老兵手术，感染，脊柱损伤，中风，出血和创伤后的死亡率 人口。因此，范博士的研究与退伍军人的健康高度相关。 Fan博士的研究提供了可用于开发的关键信息 感染后感染和阿里的退伍军人的治疗。他是高产校长 VA和NIH资金的长期记录的调查员。他还曾担任过 其他众多研究赠款的共同投资者，顾问和合作者。他的研究和 合作导致了113个同行评审的出版物，其中许多是最佳科学的出版物 期刊和高影响因素，包括自然医学，自然传播，杂志 临床研究，肝病学，肝病学杂志，细胞死亡与分化和杂志 免疫学。范博士的作品在国内和国际上以他的同龄人而闻名。他一直是 邀请了许多国家和国际会议以及许多研究的发言人 教育机构。他在许多国家同行评审委员会中担任审稿人， 包括VA，NIH，DOD和美国生物科学学院研究部分。他也服务 作为主编，编辑委员会成员，并邀请了50多个科学期刊的审稿人。他有 指导了27名VA和非VA学员，包括博士学位。候选人，博士后研究员，居民，初中 外科学院和访问学者，其中许多人现在已成为独立科学家或 医师科学家。 Fan博士是2010年获得政府卓越奖的获得者 对医学科学的贡献。