BLRD Research Career Scientist Award Application

项目总结 范杰，M.D.，M.Sc.此后一直在退伍军人事务部匹兹堡医疗系统(VAPHS)工作 2003年，退伍军人事务部研究职业科学家，外科研究项目主任，副 机构动物保护和利用委员会主席，退伍军人管理局职业发展导师 VAPHS获奖者，以及外科和免疫学系终身全职教授 匹兹堡大学外科和免疫学专业。他是首席调查员，致力于 创伤和脓毒症后全身炎症反应的细胞和分子机制 综合征(SIRS)和急性肺损伤(ALI)，这是一个重要但异常困难的领域。他的 自2007年以来，实验室一直由退伍军人事务部功绩审查补助金和NIH研究提供资金 2005年以来的补助金(R01、P50和R56)。 与创伤和败血症相关的疾病给退伍军人带来了相当大的负担。跟随 通常导致早期死亡的失血和/或脑损伤，超过60% 存活的患者后来死于与SIRS、败血症和ALI相关的原因。这位病人 人口非常适合于旨在防止这些情况发生的预防性干预措施，因为 器官发炎和衰竭前的时间延迟。尽管如此，几乎没有明确的目标 已被确定为SIRS和ALI的易感人群。范博士研究的长期目标是 对创伤后/感染后炎症和器官的机制有新的认识 并开发SIRS、脓毒症和ALI的新的预防和治疗措施。 范博士团队的研究也将提供对多发性硬化症发病机制的更多了解 炎症在其中起核心作用的人类疾病。 ALI是全身炎症反应综合征和脓毒症的共同终点之一。全身炎症反应综合征和脓毒症是引起 退伍军人手术、感染、脊柱损伤、中风、出血和创伤后的死亡率 人口。因此，范博士的研究与退伍军人的健康高度相关。 范博士是一位工作效率很高的首席研究员，在退伍军人管理局和国立卫生研究院都有长期的记录 资金问题。他还担任过联合调查员、顾问和合作者等角色 数不清的其他人的研究经费。他的研究和合作已导致136人接受同行评议 出版物，其中许多发表在第一线科学期刊上，包括自然医学、自然 通讯，临床研究杂志，肝病学，肝病学杂志，细胞死亡& 分化，和免疫学杂志。范博士的工作在全国同行中享有盛誉 在国际上。他曾被邀请在许多国内和国际会议上发言，并 在许多研究和教育机构。他在许多情况下担任正式或临时成员 国家同行审查委员会，包括美国国立卫生研究院、弗吉尼亚州、美国国防部、美国生物科学学会 研究部门和欧洲科学机构。他还担任主编、成员 编辑委员会，并邀请评审员为50多种科学期刊。 他指导了33名退伍军人事务部和退伍军人事务部WOC学员，其中包括退伍军人职业发展奖获得者、 外科住院医生、博士研究生、博士后研究员和访问学者，其中许多人 现在成为独立的科学家或内科科学家。

PROJECT SUMMARY Jie Fan, M.D., M.Sc. has been working in the VA Pittsburgh Healthcare System (VAPHS) since 2003 and is a VA Research Career Scientist, a Director of the Surgical Research Program, a Vice- Chair of the Institutional Animal Care and Use Committee, a Mentor of VA Career Development Awardees at VAPHS, and a tenured Full Professor of Surgery and Immunology in the Departments of Surgery and Immunology at the University of Pittsburgh. He is a Principal Investigator working on the cellular and molecular mechanisms of post-trauma and post-sepsis systemic inflammatory response syndrome (SIRS) and acute lung injury (ALI), an important but exceptionally difficult area. His laboratory has been continuously funded by VA merit review grants since 2007 and NIH research grants (R01, P50, and R56) since 2005. The burden of trauma- and sepsis-related diseases is considerable in veterans. Following exsanguination and/or brain injury that commonly result in early phase death, more than 60% of surviving patients later die of causes related to the development of SIRS, sepsis, and ALI. This patient population is well suited for prophylactic interventions aimed at preventing these occurrences because of the time lag before the onset of organ inflammation and failure. Nonetheless, few specific targets have been identified that predispose to SIRS and ALI. The long-term goal of Dr. Fan's studies is to provide a new understanding of the mechanisms of post-trauma/post-infection inflammation and organ dysfunction and to develop novel preventive and therapeutic interventions in SIRS, sepsis, and ALI. The studies by Dr. Fan's team will also provide a greater understanding of the pathogenesis of multiple human diseases in which inflammation plays a central role. ALI is one of the common endpoints of SIRS and sepsis. SIRS and sepsis are common causes of mortality following surgery, infection, spinal injury, stroke, hemorrhage, and trauma in the veteran population. And thus, Dr. Fan's research is highly relevant to veterans' health. Dr. Fan is a highly productive Principal Investigator with a long track record of both VA and NIH funding. He has also served in roles such as Co-Investigator, Consultant, and Collaborator on numerous other's research grants. His research and collaborations have resulted in 136 peer-reviewed publications, many of them in the first-line scientific journals, including Nature Medicine, Nature Communications, Journal of Clinical Investigation, Hepatology, Journal of Hepatology, Cell Death & Differentiation, and Journal of Immunology. Dr. Fan's work is renowned by his peers nationally and internationally. He has been an invited speaker at numerous national and international conferences and at many research and educational institutions. He serves as a regular or Ad Hoc member in a number of national peer-review committees, including NIH, VA, DoD, American Institution of Biological Sciences study sections, and European scientific institutions. He also serves as an editor-in-chief, member of editorial board, and invited reviewer for over 50 scientific journals. He has mentored 33 VA and VA WOC trainees including VA Career Development Awardee, surgery residents, Ph.D. candidates, postdoctoral fellows, and visiting scholars, many of whom have now become independent scientists or physician-scientists.