BLRD Research Career Scientist Award Application

BLRD 研究职业科学家奖申请

• 批准号: 10696603
• 负责人: Jie Fan
• 金额: --
• 依托单位: VETERANS HEALTH ADMINISTRATION
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10696603
• 关键词: Acute; Acute Lung Injury; American; Area; Autoimmune Diseases; Award; Basic Science; Biological Sciences; Brain Injuries; Cause of Death; Cell Death; Cell Differentiation process; Cells; Cessation of life; Chronic; Clinical; Clinical Research; Collaborations; Communication; Development; Disease; Doctor of Medicine; Doctor of Philosophy; Education; European; Faculty; Failure; Functional disorder; Funding; Goals; Government; Grant Review; Health; Healthcare; Healthcare Systems; Hemorrhage; Hepatology; IACUC; Immunology; Infection; Inflammation; Institution; International; Intervention; Journals; Laboratories; Literature; Medical; Medicine; Mentors; Molecular; Natural Immunity; Nature; Operative Surgical Procedures; Organ; Paper; Pathogenesis; Patients; Peer Review; Pharmaceutical Preparations; Phase; Physicians; Play; Postdoctoral Fellow; Principal Investigator; Productivity; Publications; Publishing; Reporting; Research; Research Personnel; Research Project Grants; Review Committee; Role; Science; Scientist; Sepsis; Signal Transduction; Spinal Injuries; Stroke; Study Section; Systemic Inflammatory Response Syndrome; Therapeutic Intervention; Time; Trauma; Trauma patient; United States National Institutes of Health; Universities; Veterans; Work; career; career development; clinical investigation; editorial; frontier; human disease; member; military veteran; mortality; new therapeutic target; novel; patient population; peer; post-trauma; prevent; preventive intervention; programs; prophylactic; senior faculty; septic patients; surgical research; symposium; therapy development; visiting scholar

PROJECT SUMMARY Jie Fan, M.D., M.Sc. has been working in the VA Pittsburgh Healthcare System (VAPHS) since 2003 and is a VA Research Career Scientist, a Director of the Surgical Research Program, a Vice- Chair of the Institutional Animal Care and Use Committee, a Mentor of VA Career Development Awardees at VAPHS, and a tenured Full Professor of Surgery and Immunology in the Departments of Surgery and Immunology at the University of Pittsburgh. He is a Principal Investigator working on the cellular and molecular mechanisms of post-trauma and post-sepsis systemic inflammatory response syndrome (SIRS) and acute lung injury (ALI), an important but exceptionally difficult area. His laboratory has been continuously funded by VA merit review grants since 2007 and NIH research grants (R01, P50, and R56) since 2005. The burden of trauma- and sepsis-related diseases is considerable in veterans. Following exsanguination and/or brain injury that commonly result in early phase death, more than 60% of surviving patients later die of causes related to the development of SIRS, sepsis, and ALI. This patient population is well suited for prophylactic interventions aimed at preventing these occurrences because of the time lag before the onset of organ inflammation and failure. Nonetheless, few specific targets have been identified that predispose to SIRS and ALI. The long-term goal of Dr. Fan's studies is to provide a new understanding of the mechanisms of post-trauma/post-infection inflammation and organ dysfunction and to develop novel preventive and therapeutic interventions in SIRS, sepsis, and ALI. The studies by Dr. Fan's team will also provide a greater understanding of the pathogenesis of multiple human diseases in which inflammation plays a central role. ALI is one of the common endpoints of SIRS and sepsis. SIRS and sepsis are common causes of mortality following surgery, infection, spinal injury, stroke, hemorrhage, and trauma in the veteran population. And thus, Dr. Fan's research is highly relevant to veterans' health. Dr. Fan is a highly productive Principal Investigator with a long track record of both VA and NIH funding. He has also served in roles such as Co-Investigator, Consultant, and Collaborator on numerous other's research grants. His research and collaborations have resulted in 136 peer-reviewed publications, many of them in the first-line scientific journals, including Nature Medicine, Nature Communications, Journal of Clinical Investigation, Hepatology, Journal of Hepatology, Cell Death & Differentiation, and Journal of Immunology. Dr. Fan's work is renowned by his peers nationally and internationally. He has been an invited speaker at numerous national and international conferences and at many research and educational institutions. He serves as a regular or Ad Hoc member in a number of national peer-review committees, including NIH, VA, DoD, American Institution of Biological Sciences study sections, and European scientific institutions. He also serves as an editor-in-chief, member of editorial board, and invited reviewer for over 50 scientific journals. He has mentored 33 VA and VA WOC trainees including VA Career Development Awardee, surgery residents, Ph.D. candidates, postdoctoral fellows, and visiting scholars, many of whom have now become independent scientists or physician-scientists.

项目摘要 Jie Fan，M.D.，M.Sc。由于 2003年，是VA研究职业科学家，外科研究计划的主任 机构动物护理和使用委员会主席，VA职业发展的导师 Vaphs的获奖者，以及终身的全部手术和免疫学教授 匹兹堡大学的手术和免疫学。他是一名主要调查员 后创伤后和七个后全身炎症反应的细胞和分子机制 综合征（SIRS）和急性肺损伤（ALI），这是一个重要但非常困难的区域。他的 自2007年以来，实验室一直由VA优异审查赠款和NIH研究不断资助 自2005年以来，赠款（R01，P50和R56）。 在退伍军人中，与创伤和败血症有关的疾病的负担很大。下列的 通常导致早期死亡的爆发和/或脑损伤，超过60％ 幸存的患者后来死于与Sir，败血症和Ali的发展有关的原因。这个病人 人口非常适合预防干预措施，旨在防止这些情况，因为 在器官炎症和失败发作之前的时间滞后。但是，很少有具体目标 已被确定为Sirs和Ali的易感性。范博士研究的长期目标是 对创伤后/感染后炎症和器官的机制提供新的理解 功能障碍并发展出SIRS，SEPSI和ALI的新型预防和治疗干预措施。 范博士团队的研究还将对多重发病机理有更多的了解 炎症起着核心作用的人类疾病。 阿里是爵士和败血症的常见终点之一。先生和败血症是 老兵手术，感染，脊柱损伤，中风，出血和创伤后的死亡率 人口。因此，范博士的研究与退伍军人的健康高度相关。 Fan博士是一位高产的首席研究员 资金。他还曾担任过共同投资者，顾问和合作者等角色 其他许多研究赠款。他的研究和合作导致了136个同行评审 出版物，其中许多是一线科学期刊，包括自然医学，自然 通讯，临床研究杂志，肝病学，肝病学杂志，细胞死亡和 分化和免疫学杂志。范博士的作品在全国范围内以他的同龄人而闻名 国际。他曾是众多国家和国际会议的邀请发言人 在许多研究和教育机构中。他是一个数字的常规成员或临时成员 国家同行评审委员会，包括美国国立卫生研究院，弗吉尼亚州，国防部，美国生物科学学会 研究部分和欧洲科学机构。他还担任主编， 编辑委员会，并邀请了50多种科学期刊的审稿人。 他指导了33名VA和VA WOC培训人员，包括VA职业发展获奖者， 手术居民，博士候选人，博士后研究员和访问学者，其中许多 现在成为独立的科学家或医师科学家。