BLRD Research Career Scientist Award Application

BLRD 研究职业科学家奖申请

• 批准号: 10696603
• 负责人: Jie Fan
• 金额: --
• 依托单位: VETERANS HEALTH ADMINISTRATION
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10696603
• 关键词: Acute; Acute Lung Injury; American; Area; Autoimmune Diseases; Award; Basic Science; Biological Sciences; Brain Injuries; Cause of Death; Cell Death; Cell Differentiation process; Cells; Cessation of life; Chronic; Clinical; Clinical Research; Collaborations; Communication; Development; Disease; Doctor of Medicine; Doctor of Philosophy; Education; European; Faculty; Failure; Functional disorder; Funding; Goals; Government; Grant Review; Health; Healthcare; Healthcare Systems; Hemorrhage; Hepatology; IACUC; Immunology; Infection; Inflammation; Institution; International; Intervention; Journals; Laboratories; Literature; Medical; Medicine; Mentors; Molecular; Natural Immunity; Nature; Operative Surgical Procedures; Organ; Paper; Pathogenesis; Patients; Peer Review; Pharmaceutical Preparations; Phase; Physicians; Play; Postdoctoral Fellow; Principal Investigator; Productivity; Publications; Publishing; Reporting; Research; Research Personnel; Research Project Grants; Review Committee; Role; Science; Scientist; Sepsis; Signal Transduction; Spinal Injuries; Stroke; Study Section; Systemic Inflammatory Response Syndrome; Therapeutic Intervention; Time; Trauma; Trauma patient; United States National Institutes of Health; Universities; Veterans; Work; career; career development; clinical investigation; editorial; frontier; human disease; member; military veteran; mortality; new therapeutic target; novel; patient population; peer; post-trauma; prevent; preventive intervention; programs; prophylactic; senior faculty; septic patients; surgical research; symposium; therapy development; visiting scholar

PROJECT SUMMARY Jie Fan, M.D., M.Sc. has been working in the VA Pittsburgh Healthcare System (VAPHS) since 2003 and is a VA Research Career Scientist, a Director of the Surgical Research Program, a Vice- Chair of the Institutional Animal Care and Use Committee, a Mentor of VA Career Development Awardees at VAPHS, and a tenured Full Professor of Surgery and Immunology in the Departments of Surgery and Immunology at the University of Pittsburgh. He is a Principal Investigator working on the cellular and molecular mechanisms of post-trauma and post-sepsis systemic inflammatory response syndrome (SIRS) and acute lung injury (ALI), an important but exceptionally difficult area. His laboratory has been continuously funded by VA merit review grants since 2007 and NIH research grants (R01, P50, and R56) since 2005. The burden of trauma- and sepsis-related diseases is considerable in veterans. Following exsanguination and/or brain injury that commonly result in early phase death, more than 60% of surviving patients later die of causes related to the development of SIRS, sepsis, and ALI. This patient population is well suited for prophylactic interventions aimed at preventing these occurrences because of the time lag before the onset of organ inflammation and failure. Nonetheless, few specific targets have been identified that predispose to SIRS and ALI. The long-term goal of Dr. Fan's studies is to provide a new understanding of the mechanisms of post-trauma/post-infection inflammation and organ dysfunction and to develop novel preventive and therapeutic interventions in SIRS, sepsis, and ALI. The studies by Dr. Fan's team will also provide a greater understanding of the pathogenesis of multiple human diseases in which inflammation plays a central role. ALI is one of the common endpoints of SIRS and sepsis. SIRS and sepsis are common causes of mortality following surgery, infection, spinal injury, stroke, hemorrhage, and trauma in the veteran population. And thus, Dr. Fan's research is highly relevant to veterans' health. Dr. Fan is a highly productive Principal Investigator with a long track record of both VA and NIH funding. He has also served in roles such as Co-Investigator, Consultant, and Collaborator on numerous other's research grants. His research and collaborations have resulted in 136 peer-reviewed publications, many of them in the first-line scientific journals, including Nature Medicine, Nature Communications, Journal of Clinical Investigation, Hepatology, Journal of Hepatology, Cell Death & Differentiation, and Journal of Immunology. Dr. Fan's work is renowned by his peers nationally and internationally. He has been an invited speaker at numerous national and international conferences and at many research and educational institutions. He serves as a regular or Ad Hoc member in a number of national peer-review committees, including NIH, VA, DoD, American Institution of Biological Sciences study sections, and European scientific institutions. He also serves as an editor-in-chief, member of editorial board, and invited reviewer for over 50 scientific journals. He has mentored 33 VA and VA WOC trainees including VA Career Development Awardee, surgery residents, Ph.D. candidates, postdoctoral fellows, and visiting scholars, many of whom have now become independent scientists or physician-scientists.

项目摘要 Jie Fan，医学博士，一直在VA匹兹堡医疗保健系统（VAPHS）工作， 2003年，是VA研究职业科学家，外科研究项目主任，副主任， 机构动物护理和使用委员会主席、VA职业发展导师 VAPHS的获奖者，以及外科和免疫学系的终身教授， 匹兹堡大学的外科学和免疫学。他是一名首席研究员， 创伤和脓毒症后全身炎症反应的细胞和分子机制 综合征（SIRS）和急性肺损伤（ALI），这是一个重要但异常困难的领域。他 自2007年以来，一个实验室一直得到退伍军人事务部优秀评审补助金的资助， 自2005年以来，获得了R01、P50和R56赠款。 创伤和脓毒症相关疾病的负担在退伍军人中相当大。以下 通常导致早期死亡的失血和/或脑损伤，超过60%的 存活的患者后来死于与SIRS、脓毒症和ALI的发展相关的原因。该患者 人群非常适合预防性干预措施，目的是防止这些事件的发生， 器官炎症和衰竭发生前的时间差。尽管如此， 已被确定易患SIRS和ALI。范博士研究的长期目标是 为创伤后/感染后炎症和器官损伤的机制提供了新的认识。 本研究的目的是开发SIRS、脓毒症和ALI的新型预防和治疗干预措施。 Fan博士团队的研究还将更好地了解多发性骨髓瘤的发病机制。 炎症在其中起核心作用的人类疾病。 ALI是SIRS和脓毒症的共同终点之一。SIRS和脓毒症是常见的原因 退伍军人手术、感染、脊髓损伤、中风、出血和创伤后的死亡率 人口因此，范博士的研究与退伍军人的健康高度相关。 Fan博士是一位高效的首席研究员，在VA和NIH都有长期的工作记录。 经费他还担任过以下职务： 许多其他的研究经费。他的研究和合作导致了136个同行评审 出版物，其中许多是在一线科学期刊，包括自然医学，自然 通讯，临床研究杂志，肝病学，肝病学杂志，细胞死亡与 分化和免疫学杂志。范博士的工作在全国同行中享有盛誉， 化国际大他曾应邀在许多国家和国际会议上发言， 在许多研究和教育机构。他在一些组织中担任正式成员或临时成员， 国家同行评审委员会，包括NIH、VA、DoD、美国生物科学研究所 研究部门和欧洲科学机构。他还担任主编， 编辑委员会和50多种科学期刊的特邀评审员。 他指导了33名VA和VA WOC学员，包括VA职业发展奖获得者， 外科住院医生，博士候选人，博士后研究员和访问学者，其中许多人有 现在成为独立的科学家或医生科学家。