BLR&D Research Career Scientist Award Application

项目摘要 Jie Fan，医学博士，一直在VA匹兹堡医疗保健系统（VAPHS）工作， 2003年，是多学科外科研究计划的主任， VAPHS机构生物安全委员会，以及外科系终身教授 在匹兹堡大学。他是一名主要研究人员，致力于细胞和分子 脓毒症、创伤后全身炎症反应综合征（SIRS）和急性肺损伤的机制 损伤（ALI），一个重要但异常困难的领域。他的实验室由两个VA资助。 优点审查赠款和四个NIH研究赠款（R 01，P50和R56）。 与创伤有关的疾病负担相当大。在放血和/或脑损伤后 通常导致早期死亡损伤，超过60%的存活患者后来死于 与SIRS、脓毒症和ALI的发展相关的原因。该患者人群非常适合 预防性干预措施，旨在防止这些事件的发生，因为时间滞后之前， 器官炎症和衰竭的发作。尽管如此，没有确定多少具体目标， 易患SIRS和ALI。范博士的研究的长期目标是提供一个新的理解 创伤后炎症和器官功能障碍的机制，因此， 为创伤后SIRS、脓毒症和ALI的预防和治疗干预提供了新的靶点。 Fan博士团队的研究还将更好地了解多发性骨髓瘤的发病机制。 炎症在其中起核心作用的人类疾病。 ALI是SIRS和脓毒症的共同终点之一。SIRS和脓毒症是常见的原因 退伍军人手术、感染、脊髓损伤、中风、出血和创伤后的死亡率 人口因此，范博士的研究与退伍军人的健康密切相关。 范博士的研究提供了关键信息，可用于发展 治疗创伤后炎症和急性肺损伤的退伍军人。他是一个高效率的校长 调查员与长期跟踪记录的VA和NIH的资金。他还担任过以下角色， 共同研究员，顾问，并在许多其他研究赠款的合作者。他的研究和 合作产生了113篇同行评审的出版物，其中许多是最好的科学文献。 期刊和高影响因子，包括Nature Medicine，Nature Communications， 临床研究，肝病学，肝病学杂志，细胞死亡与分化， 免疫学。范博士的工作在国内和国际上享有盛誉。他一直是一 应邀在许多国家和国际会议上发言，并在许多研究和 教育机构。他在许多国家同行评审委员会担任评审员， 包括VA、NIH、DoD和美国生物科学研究所的研究部分。老师可以相对保证学生 担任50多种科学期刊的主编、编委会成员和特邀审稿人。他 指导了27名VA和非VA学员，包括博士候选人，博士后研究员，居民，初级 外科学院和访问学者，其中许多人现在已经成为独立的科学家， 医学科学家范博士是2010年卓越政府奖的杰出获奖者。 对医学科学的贡献。

PROJECT SUMMARY Jie Fan, M.D., M.Sc. has been working in the VA Pittsburgh Healthcare System (VAPHS) since 2003, and is a Director of the Multidisciplinary Surgical Research Program, a Vice Chair of the Institutional Biosafety Committee in VAPHS, and a tenured Full Professor of the Department of Surgery at the University of Pittsburgh. He is a Principal Investigator working on the cellular and molecular mechanisms of sepsis, post-trauma systemic inflammatory response syndrome (SIRS) and acute lung injury (ALI), an important but exceptionally difficult area. His laboratory has been funded by two VA merit review grants and four NIH research grants (R01, P50, and R56). The burden of trauma-related diseases is considerable. Following exsanguination and/or brain injury that commonly result in early phase death, more than 60% of surviving patients later die of causes related to the development of SIRS, sepsis, and ALI. This patient population is well suited for prophylactic interventions aimed at preventing these occurrences because of the time lag before the onset of organ inflammation and failure. Nonetheless, few specific targets have been identified that predispose to SIRS and ALI. The long term goal of Dr. Fan’s studies is to provide a new understanding of the mechanisms of post-trauma inflammation and organ dysfunction, and therefore, to potentially provide novel targets for preventive and therapeutic interventions in post-trauma SIRS, sepsis, and ALI. The studies by Dr. Fan’s team will also provide a greater understanding of the pathogenesis of multiple human diseases in which inflammation plays a central role. ALI is one of the common endpoints of SIRS and sepsis. SIRS and sepsis are common causes of mortality following surgery, infection, spinal injury, stroke, hemorrhage, and trauma in the veteran population. And thus, Dr. Fan’s research is highly relevant to Veterans’ health. Dr. Fan’s research provides critical information that can be used toward the development of therapies for veterans with post-trauma inflammation and ALI. He is a highly productive Principal Investigator with a long track record of both VA and NIH funding. He has also served in roles such as Co-Investigator, Consultant, and Collaborator on numerous other research grants. His research and collaborations have resulted in 113 peer-reviewed publications, many of them in the best scientific journals and with high impact factors, including Nature Medicine, Nature Communications, Journal of Clinical Investigation, Hepatology, Journal of Hepatology, Cell Death & Differentiation, and Journal of Immunology. Dr. Fan’s work is renowned by his peers nationally and internationally. He has been an invited speaker at numerous national and international conferences and at many research and educational institutions. He serves as a reviewer in a number of national peer-review committees, including VA, NIH, DoD, and American Institution of Biological Sciences study sections. He also serves as editor-in-chief, member of editorial board, and invited reviewer for over 50 scientific journals. He has mentored 27 VA and non-VA trainees including Ph.D. candidates, postdoctoral fellows, residents, junior surgery faculties, and visiting scholars, many of whom have now become independent scientists or physician scientists. Dr. Fan is a 2010 recipient of the Excellence in Government Award for Outstanding Contribution to Medical Sciences.