The Michigan PBB Cohort: A unique, highly exposed community followed for 45 years and three generations

密歇根 PBB 队列：一个独特的、高度暴露的社区，已追随了 45 年和三代人

• 批准号: 9581903
• 负责人: Mark Conde
• 金额: $ 38.05万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9581903
• 关键词: Address; Adult; Affect; American; Analytical Chemistry; Apgar Score; Appropriateness Review; Biological; Blood; Breast Cancer Risk Factor; Centers for Disease Control and Prevention (U.S.); Cessation of life; Chemical Agents; Chemicals; Child; Clinical Trials; Cohort Studies; Collaborations; Communication; Communities; Community Health; Data; Data Analytics; Data Sources; Daughter; Death Certificates; Development; Dose; Electronic Health Record; Endocrine disruption; Enrollment; Environmental Epidemiology; Environmental Health; Environmental Pollution; Epidemiology; Epigenetic Process; Estrogens; Event; Exposure to; Family; Farming environment; Flame Retardants; Food Contamination; Funding; Future; Generations; Genetic; Genitourinary system; Genome; Genomics; Geographic Information Systems; Goals; Grain; Grant; Growth; Health; Imagery; Individual; Informatics; Livestock; Measures; Mediating; Menarche; Methods; Michigan; Modernization; Monoclonal Antibody R24; National Institute of Environmental Health Sciences; Newborn Infant; Nutritional; Online Systems; Outcome; Pathway interactions; Patients; Physicians; Plants; Polybrominated Biphenyls; Population; Population Surveillance; Public Health; Randomized Clinical Trials; Reproductive Health; Research; Research Infrastructure; Research Personnel; Research Support; Resolution; Resources; Risk; Running; Sampling; Scientist; Serum; Ships; Son; Source; Specimen; Speed; Spontaneous abortion; Spottings; Structure; Systems Biology; Thyroid Gland; Time; United States; United States Dept. of Health and Human Services; United States National Institutes of Health; Update; Vital Status; Woman; Work; base; biobank; cohort; consumer product; data format; data management; data resource; data sharing; data visualization; database schema; dietary supplements; epigenome; epigenomics; feeding; follow-up; improved; indexing; informatics infrastructure; innovation; longitudinal analysis; male; meetings; member; metabolome; metabolomics; offspring; persistent organic pollutants; ranpirnase; response; social media; surveillance data; transmission process; user-friendly; web portal; web site

Research Plan Summary/Abstract The Michigan PBB Cohort is the longest running, multi-generational cohort study of a widespread environmental contamination event in the United States. More than 40 years ago, millions of Michiganders ate farm products contaminated with polybrominated biphenyls (PBB), a chemical flame retardant. This cohort of approximately 7,500 individuals includes those who ate the contaminated food, chemical plant workers, their children, and their grandchildren. Extensive health, exposure, and biological samples have been collected from these individuals for four decades. While systematic updates of this cohort ceased in 2003 due to paucity of infrastructure funds, the Emory team pursued hypothesis-driven research with NIH funding. Research based on the Michigan PBB Cohort has demonstrated relationships between exposure to PBB and many health outcomes, including thyroid conditions, breast cancer risk, lower Apgar scores in children, reproductive health in daughters, and genitourinary abnormalities in sons. Current NIH-funded research includes innovative approaches involving genomics, epigenomics, exposomics and metabolomics across multiple generations as well as a randomized clinical trial of a nutritional aid hypothesized to speed elimination of PBB. The PBB research team has been exceedingly productive, contributing over 150 scientific communications. The PBB cohort has served as a source of data and biospecimens for eight NIH R01 grants, two EPA STAR grants, an NIH R03, and an NIH R21, reflecting the important scientific questions that can be addressed with this cohort. Importantly, for the last 6 years, the affected Michigan community has become a partner in the PBB research efforts, dedicating their time and resources to support the continuation of this work that is so meaningful to their family's and community's health. To assure this valuable cohort is accessible and useful for future studies and data sharing, with this R24 support we plan to update the vital status of the entire cohort and to develop a state-of-the-art data management and analytic platform. This platform will enable linkage of over 40 years of follow-up data and thousands of biospecimens. Using state of the art web-based communication, we will develop web portals to enable broad sharing of the cohort resources with three important stakeholder groups: the scientific community, cohort members (to access their own data), and local public health agencies. This infrastructure grant will support research addressing the long-term impact of exposure to brominated flame retardants, which continues to be found in the blood of the vast majority of Americans - making the intensive study of this unique cohort relevant to all Americans.

研究计划摘要/摘要 密歇根州PBB队列是最长的，多代人群的研究 在美国的环境污染事件。 40多年前，数以百万计的密歇根州吃了 农产品被多溴双苯基污染（PBB），一种阻燃剂。这个同类 大约有7,500个人包括那些吃了被污染的食物，化学植物工人及其的人 孩子和他们的孙子。从中收集了广泛的健康，暴露和生物样品 这些人持续了四十年。虽然由于缺乏 基础设施基金，埃默里团队通过NIH资助进行了假设驱动的研究。基于研究 在密歇根州PBB队列上，PBB暴露与许多健康状况之间的关系 结局，包括甲状腺状况，乳腺癌风险，儿童的APGAR评分较低，生殖健康 在女儿和儿子的泌尿生殖器异常中。当前由NIH资助的研究包括创新 涉及多代基因组学，表观基因组学，展开组学和代谢组学的方法 以及一项关于营养辅助的随机临床试验，假设消除了PBB。 PBB 研究团队的生产力极高，贡献了150多个科学沟通。 PBB 队列已成为八项NIH R01赠款，两个EPA星级赠款的数据和生物测量来源 NIH R03和NIH R21，反映了该队列可以解决的重要科学问题。 重要的是，在过去的6年中，受影响的密歇根社区已成为PBB研究的合作伙伴 努力，花时间和资源来支持这项工作对他们如此有意义的工作 家庭和社区的健康。确保这种有价值的队列对于将来的研究可访问且有用 数据共享，在此R24支持下，我们计划更新整个队列的重要状态并开发 最先进的数据管理和分析平台。该平台将启用40多年的链接 后续数据和数千个生物测量。使用基于Web的最先进的通信，我们将 开发Web门户网站，使其能够与三个重要的利益相关者群体共享队列资源： 科学界，队列成员（访问自己的数据）和当地的公共卫生机构。这 基础设施赠款将支持研究，以解决暴露于溴化火焰的长期影响 阻燃剂，在绝大多数美国人的血液中仍在发现 - 构成密集型 研究与所有美国人有关的独特队列。