The Michigan PBB Cohort: A unique, highly exposed community followed for 45 years and three generations

密歇根 PBB 队列：一个独特的、高度暴露的社区，已追随了 45 年和三代人

• 批准号: 10208887
• 负责人: Mark Conde
• 金额: $ 35.51万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10208887
• 关键词: Address; Adult; Affect; American; Analytical Chemistry; Apgar Score; Appropriateness Review; Biological; Blood; Breast Cancer Risk Factor; Centers for Disease Control and Prevention (U.S.); Cessation of life; Chemical Agents; Chemicals; Child; Clinical Trials; Cohort Studies; Collaborations; Communication; Communities; Community Health; Data; Data Analytics; Data Sources; Daughter; Death Certificates; Development; Dose; Electronic Health Record; Endocrine disruption; Enrollment; Environmental Epidemiology; Environmental Health; Environmental Pollution; Epidemiology; Epigenetic Process; Estrogens; Event; Exposure to; Family; Farming environment; Flame Retardants; Food Contamination; Funding; Future; Generations; Genetic; Genitourinary system; Genome; Genomics; Geographic Information Systems; Goals; Grain; Grant; Growth; Health; Individual; Informatics; Infrastructure; Ingestion; Livestock; Measures; Mediating; Menarche; Methods; Michigan; Modernization; Monoclonal Antibody R24; National Institute of Environmental Health Sciences; Newborn Infant; Nutritional; Online Systems; Outcome; Pathway interactions; Patients; Physicians; Plants; Polybrominated Biphenyls; Population; Population Surveillance; Public Health; Randomized Clinical Trials; Reproductive Health; Research; Research Infrastructure; Research Personnel; Research Support; Resolution; Resources; Risk; Running; Sampling; Scientist; Serum; Ships; Son; Source; Specimen; Speed; Spontaneous abortion; Spottings; Structure; Systems Biology; Thyroid Gland; Time; United States; United States Dept. of Health and Human Services; United States National Institutes of Health; Update; Visualization; Vital Status; Woman; Work; base; biobank; cohort; community engagement; consumer product; data de-identification; data format; data management; data resource; data sharing; data visualization; database schema; dietary supplements; epigenome; epigenomics; follow-up; improved; indexing; informatics infrastructure; innovation; longitudinal analysis; male; meetings; member; metabolome; metabolomics; offspring; persistent organic pollutants; ranpirnase; response; social media; surveillance data; transmission process; user-friendly; web portal; web site

Research Plan Summary/Abstract The Michigan PBB Cohort is the longest running, multi-generational cohort study of a widespread environmental contamination event in the United States. More than 40 years ago, millions of Michiganders ate farm products contaminated with polybrominated biphenyls (PBB), a chemical flame retardant. This cohort of approximately 7,500 individuals includes those who ate the contaminated food, chemical plant workers, their children, and their grandchildren. Extensive health, exposure, and biological samples have been collected from these individuals for four decades. While systematic updates of this cohort ceased in 2003 due to paucity of infrastructure funds, the Emory team pursued hypothesis-driven research with NIH funding. Research based on the Michigan PBB Cohort has demonstrated relationships between exposure to PBB and many health outcomes, including thyroid conditions, breast cancer risk, lower Apgar scores in children, reproductive health in daughters, and genitourinary abnormalities in sons. Current NIH-funded research includes innovative approaches involving genomics, epigenomics, exposomics and metabolomics across multiple generations as well as a randomized clinical trial of a nutritional aid hypothesized to speed elimination of PBB. The PBB research team has been exceedingly productive, contributing over 150 scientific communications. The PBB cohort has served as a source of data and biospecimens for eight NIH R01 grants, two EPA STAR grants, an NIH R03, and an NIH R21, reflecting the important scientific questions that can be addressed with this cohort. Importantly, for the last 6 years, the affected Michigan community has become a partner in the PBB research efforts, dedicating their time and resources to support the continuation of this work that is so meaningful to their family's and community's health. To assure this valuable cohort is accessible and useful for future studies and data sharing, with this R24 support we plan to update the vital status of the entire cohort and to develop a state-of-the-art data management and analytic platform. This platform will enable linkage of over 40 years of follow-up data and thousands of biospecimens. Using state of the art web-based communication, we will develop web portals to enable broad sharing of the cohort resources with three important stakeholder groups: the scientific community, cohort members (to access their own data), and local public health agencies. This infrastructure grant will support research addressing the long-term impact of exposure to brominated flame retardants, which continues to be found in the blood of the vast majority of Americans - making the intensive study of this unique cohort relevant to all Americans.

研究计划摘要/摘要 密歇根 PBB 队列是针对广泛存在的、持续时间最长的多代队列研究。 美国环境污染事件。 40 多年前，数百万密歇根人吃了 农产品受到多溴联苯（PBB）（一种化学阻燃剂）的污染。这一批 大约 7,500 人包括食用受污染食品的人、化工厂工人及其家人 孩子们和他们的孙子们。已从以下地点收集了大量的健康、暴露和生物样本 这些人四十年来。虽然该队列的系统更新于 2003 年因缺乏 基础设施基金，埃默里大学团队利用 NIH 的资助进行假设驱动的研究。研究为基础 密歇根州 PBB 队列研究表明，接触 PBB 与许多健康之间存在关系 结果，包括甲状腺疾病、乳腺癌风险、儿童阿普加评分较低、生殖健康 女儿出现泌尿生殖系统异常，儿子出现泌尿生殖系统异常。当前 NIH 资助的研究包括创新 涉及跨代的基因组学、表观基因组学、暴露组学和代谢组学的方法 以及一项假设可以加速消除多溴联苯的营养辅助剂的随机临床试验。多溴联苯 研究团队非常富有成效，贡献了 150 多项科学通讯。多溴联苯 该队列已成为八项 NIH R01 拨款、两项 EPA STAR 拨款、一项 NIH R03 和 NIH R21，反映了该队列可以解决的重要科学问题。 重要的是，在过去 6 年里，受影响的密歇根社区已成为 PBB 研究的合作伙伴 努力，投入时间和资源来支持这项对他们来说非常有意义的工作的继续 家庭和社区的健康。为了确保这个有价值的队列对于未来的研究是可访问的和有用的 数据共享，借助 R24 支持，我们计划更新整个队列的生命状态并开发一个 最先进的数据管理和分析平台。该平台将连接 40 多年的 后续数据和数千个生物样本。使用最先进的基于网络的通信，我们将 开发门户网站，以便与三个重要的利益相关者群体广泛共享队列资源： 科学界、队列成员（访问自己的数据）和当地公共卫生机构。这 基础设施拨款将支持解决暴露于溴化火焰的长期影响的研究 阻燃剂，它仍然存在于绝大多数美国人的血液中 - 使得密集 对这个与所有美国人相关的独特群体的研究。