The Michigan PBB Cohort: A unique, highly exposed community followed for 45 years and three generations

研究计划摘要/摘要 密歇根多溴联苯队列是一项持续时间最长的多代队列研究， 美国的环境污染事件。40多年前，数以百万计的饥饿者 受多溴联苯（一种化学阻燃剂）污染的农产品。这群 大约有7,500人，包括那些吃了受污染食物的人，化工厂工人， 孩子和他们的孙子。已收集了大量的健康、暴露和生物样本， 这些人四十年来。虽然由于缺乏对这一组的系统更新， 在基础设施基金的支持下，埃默里大学的研究小组在NIH的资助下进行了假设驱动的研究。研究为基础 密歇根州多溴联苯队列研究表明，接触多溴联苯与许多健康问题之间存在关系。 结果，包括甲状腺疾病，乳腺癌风险，儿童Apgar评分较低，生殖健康 女儿和儿子的泌尿生殖系统异常。目前NIH资助的研究包括创新的 方法涉及基因组学，表观基因组学，基因组学和代谢组学跨多代， 以及一项关于营养辅助剂的随机临床试验，该营养辅助剂假设可加速消除多溴联苯。了PBB 研究团队一直非常富有成效，贡献了150多个科学通信。了PBB 队列已作为八个NIH R 01赠款，两个EPA星星赠款， NIH R 03和NIH R21，反映了该队列可以解决的重要科学问题。 重要的是，在过去6年中，受影响的密歇根社区已成为PBB研究的合作伙伴 努力，奉献他们的时间和资源，以支持继续这项工作，这是如此有意义的，他们的工作。 家庭和社区的健康。为了确保这一有价值的队列是可访问的，并对未来的研究有用， 数据共享，有了R24的支持，我们计划更新整个队列的生命状态，并制定一个 最先进的数据管理和分析平台。该平台将使40多年的 后续数据和数千份生物样本使用最先进的基于网络的通信，我们将 开发门户网站，以便与三个重要的利益攸关方群体广泛分享群组资源： 科学界、群组成员（访问他们自己的数据）和当地公共卫生机构。这 基础设施赠款将支持研究解决暴露于溴化火焰的长期影响 在绝大多数美国人的血液中仍然可以发现这种物质， 研究这个与所有美国人相关的独特群体。

Research Plan Summary/Abstract The Michigan PBB Cohort is the longest running, multi-generational cohort study of a widespread environmental contamination event in the United States. More than 40 years ago, millions of Michiganders ate farm products contaminated with polybrominated biphenyls (PBB), a chemical flame retardant. This cohort of approximately 7,500 individuals includes those who ate the contaminated food, chemical plant workers, their children, and their grandchildren. Extensive health, exposure, and biological samples have been collected from these individuals for four decades. While systematic updates of this cohort ceased in 2003 due to paucity of infrastructure funds, the Emory team pursued hypothesis-driven research with NIH funding. Research based on the Michigan PBB Cohort has demonstrated relationships between exposure to PBB and many health outcomes, including thyroid conditions, breast cancer risk, lower Apgar scores in children, reproductive health in daughters, and genitourinary abnormalities in sons. Current NIH-funded research includes innovative approaches involving genomics, epigenomics, exposomics and metabolomics across multiple generations as well as a randomized clinical trial of a nutritional aid hypothesized to speed elimination of PBB. The PBB research team has been exceedingly productive, contributing over 150 scientific communications. The PBB cohort has served as a source of data and biospecimens for eight NIH R01 grants, two EPA STAR grants, an NIH R03, and an NIH R21, reflecting the important scientific questions that can be addressed with this cohort. Importantly, for the last 6 years, the affected Michigan community has become a partner in the PBB research efforts, dedicating their time and resources to support the continuation of this work that is so meaningful to their family's and community's health. To assure this valuable cohort is accessible and useful for future studies and data sharing, with this R24 support we plan to update the vital status of the entire cohort and to develop a state-of-the-art data management and analytic platform. This platform will enable linkage of over 40 years of follow-up data and thousands of biospecimens. Using state of the art web-based communication, we will develop web portals to enable broad sharing of the cohort resources with three important stakeholder groups: the scientific community, cohort members (to access their own data), and local public health agencies. This infrastructure grant will support research addressing the long-term impact of exposure to brominated flame retardants, which continues to be found in the blood of the vast majority of Americans - making the intensive study of this unique cohort relevant to all Americans.