The Michigan PBB Cohort: A unique, highly exposed community followed for 45 years and three generations

研究计划摘要/摘要 密歇根PBB队列是持续时间最长的、多代人的广泛研究 美国发生的环境污染事件。40多年前，数百万密歇根州人吃 受化学阻燃剂多溴联苯(PBB)污染的农产品。这群人 大约7500人包括那些吃了受污染食物的人，化工厂工人，他们的 孩子和他们的孙子孙女。已从以下地点收集了广泛的健康、暴露和生物样本 这些人已经40年了。虽然这一队列的系统更新在2003年停止，因为缺乏 基础设施基金方面，Emory团队利用NIH的资金进行了假说驱动的研究。以研究为基础 在密歇根州，PBB队列已经证明了暴露于PBB与许多健康之间的关系 结果，包括甲状腺状况、乳腺癌风险、儿童较低的阿普加评分、生殖健康 在女儿身上，在儿子身上有生殖器异常。目前由NIH资助的研究包括创新 涉及多代基因组学、表观基因组学、暴露组学和代谢组学的方法 以及一项关于一种营养辅助的随机临床试验，该试验假定可以加速PBB的消除。中国人民银行 研究团队卓有成效，贡献了150多项科学交流。中国人民银行 队列已成为八项NIH R01赠款、两项EPA STAR赠款、以及 NIH R03和NIH R21，反映了可以通过该队列解决的重要科学问题。 重要的是，在过去的6年里，受影响的密歇根州社区已经成为PBB研究的合作伙伴 努力，奉献他们的时间和资源来支持这项工作的继续，这对他们的 家庭和社区的健康。以确保这个有价值的队列是可访问的，并对未来的研究和 数据共享，通过此R24支持，我们计划更新整个队列的重要状态，并制定 最先进的数据管理和分析平台。该平台将使40多年来 追踪数据和数以千计的生物标本。使用最先进的基于网络的通信，我们将 开发门户网站，以便与三个重要的利益攸关方群体广泛共享队列资源： 科学界、队列成员(获取他们自己的数据)和当地公共卫生机构。这 基础设施赠款将支持研究暴露在溴化火焰中的长期影响 阻燃剂，它仍然存在于绝大多数美国人的血液中-使密集的 对这一与所有美国人相关的独特群体的研究。

Research Plan Summary/Abstract The Michigan PBB Cohort is the longest running, multi-generational cohort study of a widespread environmental contamination event in the United States. More than 40 years ago, millions of Michiganders ate farm products contaminated with polybrominated biphenyls (PBB), a chemical flame retardant. This cohort of approximately 7,500 individuals includes those who ate the contaminated food, chemical plant workers, their children, and their grandchildren. Extensive health, exposure, and biological samples have been collected from these individuals for four decades. While systematic updates of this cohort ceased in 2003 due to paucity of infrastructure funds, the Emory team pursued hypothesis-driven research with NIH funding. Research based on the Michigan PBB Cohort has demonstrated relationships between exposure to PBB and many health outcomes, including thyroid conditions, breast cancer risk, lower Apgar scores in children, reproductive health in daughters, and genitourinary abnormalities in sons. Current NIH-funded research includes innovative approaches involving genomics, epigenomics, exposomics and metabolomics across multiple generations as well as a randomized clinical trial of a nutritional aid hypothesized to speed elimination of PBB. The PBB research team has been exceedingly productive, contributing over 150 scientific communications. The PBB cohort has served as a source of data and biospecimens for eight NIH R01 grants, two EPA STAR grants, an NIH R03, and an NIH R21, reflecting the important scientific questions that can be addressed with this cohort. Importantly, for the last 6 years, the affected Michigan community has become a partner in the PBB research efforts, dedicating their time and resources to support the continuation of this work that is so meaningful to their family's and community's health. To assure this valuable cohort is accessible and useful for future studies and data sharing, with this R24 support we plan to update the vital status of the entire cohort and to develop a state-of-the-art data management and analytic platform. This platform will enable linkage of over 40 years of follow-up data and thousands of biospecimens. Using state of the art web-based communication, we will develop web portals to enable broad sharing of the cohort resources with three important stakeholder groups: the scientific community, cohort members (to access their own data), and local public health agencies. This infrastructure grant will support research addressing the long-term impact of exposure to brominated flame retardants, which continues to be found in the blood of the vast majority of Americans - making the intensive study of this unique cohort relevant to all Americans.