Biomolecular Analysis Facility

生物分子分析设备

• 批准号: 9759088
• 负责人: Nicholas Eugene Sherman
• 金额: $ 1.02万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9759088
• 关键词: Address; Advisory Committees; Animal Disease Models; Area; Binding; Budgets; Cancer Center; Cancer Center Support Grant; Clinical; Computers and Advanced Instrumentation; Consultations; Data Analyses; Data Collection; Data Quality; Development; Ensure; Environment; Evaluation; Floor; Flow Cytometry; Fostering; Foxes; Funding; Genome; Genomics; Grant; Human Resources; Investigation; Jordan; Kinetics; Knowledge; Malignant Neoplasms; Measurement; Measures; Methods; Microscopy; Paper; Phase; Price; Proteomics; Publications; Research; Research Personnel; Resolution; Resource Sharing; Resources; Sampling; Services; Techniques; Technology; Tissues; University of Virginia Cancer Center; Water; Work; Writing; analytical method; anticancer research; base; biobank; cost effective; design; digital; driving force; experience; experimental study; instrument; instrumentation; mass spectrometer; medical schools; member; metabolomics; multiple omics; new technology; next generation sequencing; research facility; response; tool; transcriptomics

BIOMOLECULAR ANALYSIS FACILITY – PROJECT SUMMARY/ABSTRACT The Biomolecular Analysis Facility (BAF) provides a centralized setting for a diverse but interactive suite of services, instrumentation, and expertise in the areas of genomics, transcriptomics, proteomics, metabolomics, lipidomics, and molecular interactions. BAF research services have been provided to the Cancer Center for nearly 20 years, with recent additions addressing new areas of investigator need identified by the Cancer Center Executive Committee. The highly skilled staff has the necessary expertise to provide Cancer Center members with not only rapid, high quality data but also with pre- and post-experiment consultation necessary for successful experiments. This complete approach to service gives investigators confidence in their work leading to publications and additional grants. The labs, instruments, and personnel of the BAF are all located on the first floor of Jordan Hall allowing Cancer Center members to easily utilize and integrate multiple `omics' techniques in their research. In addition, the BAF has significant ties to other Cancer Center shared resources such as Flow Cytometry, Biorepository and Tissue Research Facility, Animal Models of Disease, and Advanced Microscopy Facility. In some cases, these facilities provide the samples/material utilized in the BAF while in others they use BAF-generated results to initiate further research experiments. One key area of focus within the BAF is providing access to advanced instrumentation and experiments that meet Cancer Center needs. Within the past year, the facility has added two mass spectrometers in the area of lipidomics and metabolomics and an instrument capable of measuring molecular interactions. As the majority of BAF users are Cancer Center members, the interaction with these investigators is the driving force for acquisition of new instrumentation and development of new techniques. The Cancer Center Executive Committee and Office of Research Core Administration (ORCA – within School of Medicine Dean's Office) work closely together to foster this environment. To that end the School of Medicine provides direct budget support to the BAF every year (~30% total budget). When the Cancer Center co-pay is combined with the School of Medicine's support, Cancer Center Members receive highly effective services at a price that makes more experiments possible.

生物分子分析公司-项目总结/摘要 生物分子分析设施（BAF）提供了一个集中的环境， 在基因组学、转录组学、蛋白质组学、 代谢组学、脂质组学和分子相互作用。BAF研究服务已提供给 癌症中心近20年，最近增加了解决新领域的研究者需要确定 癌症中心执行委员会。高技能的员工拥有必要的专业知识， 癌症中心成员不仅可以快速获得高质量的数据，还可以在实验前和实验后获得 成功的实验所需的咨询。这种完整的服务方法使研究人员 对他们的工作充满信心，导致出版物和额外的赠款。实验室、仪器和人员 BAF都位于约旦大厅的一楼，让癌症中心的成员可以方便地使用， 在他们的研究中整合多种“组学”技术。此外，BAF与其他癌症有着重要的联系。 中心共享资源，如流式细胞术，生物储存和组织研究设施，动物模型 先进的显微镜设备。在某些情况下，这些机构提供样品/材料 在生物曝气生物滤池中使用生物曝气生物滤池产生的结果，而在其他生物曝气生物滤池中使用生物曝气生物滤池产生的结果，以启动进一步的研究实验。 BAF的一个重点领域是提供先进的仪器和实验， 满足癌症中心的需求。在过去的一年里，该设施在以下领域增加了两台质谱仪： 脂质组学和代谢组学以及能够测量分子相互作用的仪器。因为大多数 的BAF用户是癌症中心的成员，与这些研究人员的互动是 购置新仪器和开发新技术。癌症中心执行官 研究核心管理委员会和办公室（ORCA -在医学院院长办公室） 密切合作，营造这样的环境。为此，医学院提供直接预算 每年向BAF提供支持（约占总预算的30%）。当癌症中心共同支付与 在医学院的支持下，癌症中心的会员可以获得高效的服务， 更多的实验可能。