Sentinel Enhanced Dengue Surveillance System (SEDSS) Sites to Evaluate the Epidemiology and Prevention of Dengue and other Acute Febrile Illnesses in Puerto Rico

哨兵增强登革热监测系统 (SEDSS) 站点，用于评估波多黎各登革热和其他急性发热性疾病的流行病学和预防

• 批准号: 9770634
• 负责人: Vanessa Rivera-Amill
• 金额: $ 157.23万
• 依托单位: PONCE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9770634
• 关键词: Sentinel; Enhanced; Dengue; Surveillance; System

 DESCRIPTION (provided by applicant): The global burden of dengue is large with an estimated 50 million infections per year occurring across 100 countries. Puerto Rico, a Commonwealth of the USA, has the largest US population with endemic dengue. The island offers a unique opportunity to study the epidemiology, outcomes and prevention of dengue, as well as its clinical presentation and how dengue can be differentiated from other Acute Febrile Illnesses (AFI), such as chikungunya, transmitted by the same vector. The Saint Luke's Episcopal Hospital and Ponce School of Medicine Consortium has implemented a Sentinel Enhanced Dengue Surveillance System (SEDSS) through a Cooperative Agreement with the CDC that serves as a model of enhanced surveillance and an effective research platform to conduct studies on dengue and other AFI. Lessons learned from SEDSS implementation have been applied to this proposal to support and improve on the current enhanced surveillance site and to build on its strengths. The new project: Sentinel Enhanced Dengue Surveillance System to Evaluate Dengue Epidemiology, Outcomes and Prevention (SEDSS-EDEOP) will work to sustain the interest and commitment of hospital's administration, foster collaboration between the medical school, the public health program, the hospital and the community, as well as develop research capacity in medical residents, and medical and public health students that will create the future of dengue research in Puerto Rico. In addition to enhanced surveillance, the SEDSS-EDEOP Project will develop a comparative effectiveness research program to study dengue management strategies in a real world setting. This program should yield information on best practices that can be applied by clinicians to improve dengue outcomes. The SEDSS-EDEOP Project is likely to result in a model of enhanced epidemiologic surveillance and a strong research platform for studying dengue and AFI and the impact of primary and secondary dengue prevention strategies.

 描述（由申请人提供）：登革热的全球负担很大，估计每年在100个国家发生5000万例感染。波多黎各是美国的一个联邦，拥有美国最大的登革热流行人口。该岛提供了一个独特的机会来研究登革热的流行病学，结果和预防，以及其临床表现，以及如何将登革热与其他急性发热性疾病（AFI）区分开来，如基孔肯雅病，由同一媒介传播。圣卢克主教医院和庞塞医学院联盟通过与疾病预防控制中心的合作协议实施了哨兵加强登革热监测系统（SEDSS），作为加强监测的模式和有效的研究平台，对登革热和其他AFI进行研究。从SEDSS实施中吸取的经验教训已被应用到本提案中，以支持和改进目前的强化监测网站，并加强其优势。新项目：哨点加强登革热监测系统评估登革热流行病学、结果和预防（SEDSS-EDEOP）将努力维持医院管理部门的兴趣和承诺，促进医学院、公共卫生项目、医院和社区之间的合作，并发展住院医师的研究能力，以及医学和公共卫生专业的学生，他们将在波多黎各开创登革热研究的未来。除了加强监测外，SEDSS-EDEOP项目还将制定一项比较有效性研究计划，以研究真实的世界环境中的登革热管理策略。该计划应产生有关临床医生可用于改善登革热结果的最佳实践的信息。SEDSS-EDEOP项目可能会产生一个加强流行病学监测的模型和一个强大的研究平台，用于研究登革热和AFI以及初级和二级登革热预防策略的影响。