Sentinel Enhanced Dengue Surveillance System (SEDSS) Sites to Evaluate the Epidemiology and Prevention of Dengue and other Acute Febrile Illnesses in Puerto Rico

 描述(由申请人提供)：全球登革热负担很大，估计每年在100个国家发生5000万例感染。波多黎各是美国的一个联邦，是美国登革热流行人口最多的国家。该岛提供了一个独特的机会，可以研究登革热的流行病学、结果和预防，以及登革热的临床表现，以及如何将登革热与通过同一媒介传播的基孔肯雅热等其他急性发烧疾病区分开来。圣卢克圣公会医院和庞塞医学院联合体通过与疾控中心的合作协议实施了哨兵增强型登革热监测系统，作为加强监测的典范和进行登革热和其他AFI研究的有效研究平台。已将从实施SEDSS中吸取的经验教训应用于这项提议，以支持和改进目前强化的监测地点，并加强其优势。新项目：评估登革热流行病学、结果和预防的哨兵增强型登革热监测系统(SEDSS-EDEOP)将致力于维持医院管理部门的兴趣和承诺，促进医学院、公共卫生项目、医院和社区之间的合作，以及培养住院医生、医学和公共卫生学生的研究能力，从而创造波多黎各登革热研究的未来。除了加强监测外，SEDSS-EDEOP项目还将开发一项比较有效性研究计划，以研究现实世界中的登革热管理策略。该计划应提供有关最佳实践的信息，供临床医生应用以改善登革热结果。SEDSS-EDEOP项目可能产生一个加强流行病学监测的模式，以及一个研究登革热和AFI以及登革热一级和二级预防战略的影响的强大研究平台。

 DESCRIPTION (provided by applicant): The global burden of dengue is large with an estimated 50 million infections per year occurring across 100 countries. Puerto Rico, a Commonwealth of the USA, has the largest US population with endemic dengue. The island offers a unique opportunity to study the epidemiology, outcomes and prevention of dengue, as well as its clinical presentation and how dengue can be differentiated from other Acute Febrile Illnesses (AFI), such as chikungunya, transmitted by the same vector. The Saint Luke's Episcopal Hospital and Ponce School of Medicine Consortium has implemented a Sentinel Enhanced Dengue Surveillance System (SEDSS) through a Cooperative Agreement with the CDC that serves as a model of enhanced surveillance and an effective research platform to conduct studies on dengue and other AFI. Lessons learned from SEDSS implementation have been applied to this proposal to support and improve on the current enhanced surveillance site and to build on its strengths. The new project: Sentinel Enhanced Dengue Surveillance System to Evaluate Dengue Epidemiology, Outcomes and Prevention (SEDSS-EDEOP) will work to sustain the interest and commitment of hospital's administration, foster collaboration between the medical school, the public health program, the hospital and the community, as well as develop research capacity in medical residents, and medical and public health students that will create the future of dengue research in Puerto Rico. In addition to enhanced surveillance, the SEDSS-EDEOP Project will develop a comparative effectiveness research program to study dengue management strategies in a real world setting. This program should yield information on best practices that can be applied by clinicians to improve dengue outcomes. The SEDSS-EDEOP Project is likely to result in a model of enhanced epidemiologic surveillance and a strong research platform for studying dengue and AFI and the impact of primary and secondary dengue prevention strategies.