Comprehensive Glycoproteomic Tool Development for Cancer Biomarkers
Comprehensive Glycoproteomic Tool Development for Cancer Biomarkers
批准号:
9769771
负责人:
MARSHALL Wayne BERN
金额:
$31.56万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2014
资助国家:
美国
项目状态:
已结题
起止时间:
2014-09-22 至 2021-02-28
关键词:
AcademiaAlgorithmic SoftwareAlgorithmsAliquotArchivesAreaBasic ScienceBindingBiologicalBiological MarkersBiological ProductsBiological TestingBudgetsCarbonCattleClinicalCommunitiesComputer SimulationComputer softwareCustomCyst FluidDataData AnalysesDevelopmentDigestionEnzymesEsterificationExoglycosidasesFluorescenceGlycopeptidesGoalsHealthHumanIndustryIonsLabelLaboratoriesLaboratory ResearchLactoferrinLectinLinkLiquid ChromatographyLiteratureManualsMass Spectrum AnalysisMediatingMethodsMonoclonal AntibodiesNamesNatural graphiteOligosaccharidesOrosomucoidOutputPeptide MappingPhasePlasmaPolysaccharidesPost-Translational Protein ProcessingProgress ReportsProtein GlycosylationProteinsRecombinantsReportingResearch PersonnelSamplingSerotransferrinSialic AcidsSignal TransductionSmall Business Technology Transfer ResearchSoftware ToolsSpecimenSpectrometrySpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationStructureSurveysSystemTimeTissue SampleUnited States National Institutes of HealthValidationWorkalpha-Fetoproteinsanalytical methodbasebiological researchbiomarker developmentbiomarker discoverycancer biomarkersclinical applicationdrug developmentexperimental studyglycoproteomicsglycosylationimprovedinformatics toolinterestion mobilitynew technologypancreatic cancer patientsprogramsresponsesoftware developmentsupport toolstandem mass spectrometrytherapeutic proteintooltool developmentvaccine development
中文摘要
项目总结
英文摘要
Project Summary
Glycosylation is one of the most prevalent and important post-translational modifications of proteins, yet it
is also one of the most difficult to study. No single method nor analytical platform can give complete
information about the glycosylation in a protein sample, and the analytical methods in current use include both
ESI and MALDI single and tandem mass spectrometry, at least four types of liquid chromatography, iterative
enzyme analysis, glycan-binding experiments with fluorescence read-out, and new methods such as ion
mobility spectrometry. There is currently no software platform that can integrate even two of these different
data channels. In this project we propose to build a software product called GlycoForm that will be capable of
analyzing, visualizing, and integrating glycosylation data over multiple channels. GlycoForm will be able to
identify released glycans to the level of detail warranted by the evidence and quantify them using either mass
spectrometry or fluorescence signals. The software will include both an interactive user interface for expert
inspection, and also customized and automated glycosylation reports for sharing and archiving. The initial
release of GlycoForm will handle single and tandem mass spectrometry, chromatographic elution time, and
glycan-binding experiments; other data channels will be added later in response to customer demand.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
New Algorithms and Software for Mass Spectrometric Analysis of Intact Proteins and Complexes
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批准号:10155924
-
项目类别:
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资助金额:$79.96万
-
财政年份:2019
-
负责人:MARSHALL Wayne BERN
-
依托单位:
New Algorithms and Software for Mass Spectrometric Analysis of Intact Proteins and Complexes
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批准号:10333416
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项目类别:
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资助金额:$79.58万
-
财政年份:2019
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负责人:MARSHALL Wayne BERN
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依托单位:
Integrated Platform for Mass-Spectrometric Studies of Protein Structure
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批准号:9909995
-
项目类别:
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资助金额:$61.39万
-
财政年份:2017
-
负责人:MARSHALL Wayne BERN
-
依托单位:
Integrated Platform for Mass-Spectrometric Studies of Protein Structure
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批准号:10092176
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项目类别:
-
资助金额:$61.42万
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财政年份:2017
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负责人:MARSHALL Wayne BERN
-
依托单位:
Advancing Protein Identification for Imaging Mass Spectrometry for Pathology
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批准号:8314708
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项目类别:
-
资助金额:$34.86万
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财政年份:2012
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负责人:MARSHALL Wayne BERN
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依托单位:
Advancing Protein Identification for Imaging Mass Spectrometry for Pathology
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批准号:8539636
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项目类别:
-
资助金额:$17.7万
-
财政年份:2012
-
负责人:MARSHALL Wayne BERN
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依托单位:
DEVELOPMENT OF DE NOVO SEQUENCING ALGORITHMS
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批准号:8361561
-
项目类别:
-
资助金额:$0.34万
-
财政年份:2011
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负责人:MARSHALL Wayne BERN
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依托单位:
Algorithms and Software for Protein-Family De Novo Sequencing
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批准号:8119094
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项目类别:
-
资助金额:$25.15万
-
财政年份:2010
-
负责人:MARSHALL Wayne BERN
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依托单位:
DEVELOPMENT OF DE NOVO SEQUENCING ALGORITHMS
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批准号:8169190
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项目类别:
-
资助金额:$0.27万
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财政年份:2010
-
负责人:MARSHALL Wayne BERN
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依托单位:
Algorithms and Software for Protein-Family De Novo Sequencing
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批准号:7963658
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项目类别:
-
资助金额:$30.52万
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财政年份:2010
-
负责人:MARSHALL Wayne BERN
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依托单位:
Widely Distributed Software for Using Mass Spectrometry to Identify Glycans
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批准号:8459377
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项目类别:
-
资助金额:$38.88万
-
财政年份:2010
-
负责人:MARSHALL Wayne BERN
-
依托单位:
Widely Distributed Software for Using Mass Spectrometry to Identify Glycans
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批准号:7936624
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项目类别:
-
资助金额:$41.41万
-
财政年份:2010
-
负责人:MARSHALL Wayne BERN
-
依托单位:
Widely Distributed Software for Using Mass Spectrometry to Identify Glycans
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批准号:8113309
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项目类别:
-
资助金额:$40.99万
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财政年份:2010
-
负责人:MARSHALL Wayne BERN
-
依托单位:
Widely Distributed Software for Using Mass Spectrometry to Identify Glycans
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批准号:8261895
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项目类别:
-
资助金额:$40.99万
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财政年份:2010
-
负责人:MARSHALL Wayne BERN
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依托单位:
Algorithms and Software for Difficult Proteomics Problems
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批准号:7942355
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项目类别:
-
资助金额:$17.99万
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财政年份:2009
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负责人:MARSHALL Wayne BERN
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依托单位:
Algorithms and Software for Difficult Proteomics Problems
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批准号:7646521
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项目类别:
-
资助金额:$25.96万
-
财政年份:2008
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负责人:MARSHALL Wayne BERN
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依托单位:
Algorithms and Software for Difficult Proteomics Problems
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批准号:7512236
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项目类别:
-
资助金额:$31.09万
-
财政年份:2008
-
负责人:MARSHALL Wayne BERN
-
依托单位:
海外基金