DEVELOPMENT OF DE NOVO SEQUENCING ALGORITHMS

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 我们正在与马歇尔伯尔尼合作，优化他的搜索算法。他正在编写用于毒素和艾滋病毒样本的从头软件。描述这项工作的一份文件正在印刷中： 多肽的限制性从头测序及其在芋螺毒素中的应用 Swapnil Bhatia，Yong J. Kil，Beatrix Ueberheide，Brian Chait 放大图片作者：Lemmuel Tayo，John R. Yates，III，马歇尔伯尔尼J.计算生物学，出版中

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We are working with Marshall Bern to optimize his search algorithms. He is writing de novo software to be used on toxin and HIV samples. A paper describing this work is in press: Constrained de novo Sequencing of Peptides with Application to Conotoxins Swapnil Bhatia, Yong J. Kil, Beatrix Ueberheide, Brian Chait Lemmuel Tayo, Bingwen Lu, John R. Yates, III, Marshall Bern J. Computational Biology, In press