ShEEP Request for CytoViva 3D Darkfield Hyperspectral Microscope

ShEEP 请求 CytoViva 3D 暗场高光谱显微镜

基本信息

  • 批准号:
    9906462
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-09-01 至 2020-09-30
  • 项目状态:
    已结题

项目摘要

One of the challenges in areas of drug development and drug delivery for treating various human diseases is the lack of understanding of the inherent cellular barriers that restrict the drug efficacy. Another challenge encountered by researchers conducting intracellular trafficking of molecules and their localization in cellular organelles is in the use of fluorescent labels that distort the study results with negative influence of these labels on samples. Further, lack of availability of adequate instrumentation restricts investigators from conducting cutting-edge research at their own institute. As a result they have to ship their materials to institutions/universities which are time-consuming, expensive, and do not give the investigator to know the results quickly. Therefore, continuous expansion of research infrastructure by acquiring appropriate equipment’s will enhance research activities among research investigator and lead to new discoveries. To override some of these limitations, we are requesting funds to purchase the CytoViva 3D Enhanced Darkfield Hyperspectral Microscope for enhancing the research conducted by investigators at the Oklahoma City VA Health Care System. This system offers high signal-to-noise 3D enhanced darkfield optical hyperspectral imaging specifically designed for imaging of label free particles/molecules in label-free or fluorescently labeled live cells and ex-vivo tissue matrices. The unique patented technology of the microscope allows the visualization and monitoring of particles, drugs, biologics, and cells in solution and in translucent matrices (cells, tissues, organisms). Thus, studies investigating binding of material (drug, nanoparticle, cell- particle interaction, antibody binding to cell), receptor-mediated binding and entry into cells (nanoparticles, quantum-dots, virus, bacteria, metals, antibodies) and intracellular localization and trafficking (siRNA, plasmid DNA, nanoparticles, virus, bacteria, spores) via various intracellular organelles can be determined in vitro and in ex-vivo tissue explants with label-free imaging and capture images. The system with the requisite computer software system provides quantitative spectral analysis of biological and non-biological materials imaged. The protocols can be automated giving the user to ‘walk-away’ from the instrument, and perform other experiments. Most importantly, neither the Oklahoma City VA Health Care System nor the affiliated University of Oklahoma Health Sciences Center (OUHSC) has such an instrument that enables high precision analysis of label-free materials in cells or ex-vivo tissues. Therefore, this is a truly unique and valuable resource justifying it purchase as a resource for investigators to conduct existing and new areas of research at the Oklahoma City VA Health Care System. Availability of this equipment will enhance ongoing studies and establish new areas of research benefitting the men and women serving the military and veterans. The equipment will be used by six-major users and a number of future VA users who have six VA Merit grants funded, three senior career scientist awards, and one career development award funded.
治疗各种人类疾病的药物开发和药物输送领域的挑战之一

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Rajagopal Ramesh其他文献

Rajagopal Ramesh的其他文献

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{{ truncateString('Rajagopal Ramesh', 18)}}的其他基金

Engineered Nanoformulation for Immune-modulation in Cancer
用于癌症免疫调节的工程纳米制剂
  • 批准号:
    10719487
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
Exosomes as carriers of cancer therapeutics
外泌体作为癌症治疗的载体
  • 批准号:
    10312645
  • 财政年份:
    2021
  • 资助金额:
    --
  • 项目类别:
An improved IL-24 gene-based therapeutic for cancer
改进的基于 IL-24 基因的癌症疗法
  • 批准号:
    10326352
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
An improved IL-24 gene-based therapeutic for cancer
改进的基于 IL-24 基因的癌症疗法
  • 批准号:
    10544003
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
Cancer Research Training and Education Coordination
癌症研究培训和教育协调
  • 批准号:
    10627028
  • 财政年份:
    2018
  • 资助金额:
    --
  • 项目类别:
Molecular Impact of Platinum Drugs on the Proteasome and SQSTM1_P62 Complexes_A Paradigm Shift in Resistance
铂类药物对蛋白酶体和 SQSTM1_P62 复合物的分子影响_耐药范式转变
  • 批准号:
    10051382
  • 财政年份:
    2017
  • 资助金额:
    --
  • 项目类别:
Molecular Impact of Platinum Drugs on the Proteasome and SQSTM1_P62 Complexes_A Paradigm Shift in Resistance
铂类药物对蛋白酶体和 SQSTM1_P62 复合物的分子影响_耐药范式转变
  • 批准号:
    9478535
  • 财政年份:
    2017
  • 资助金额:
    --
  • 项目类别:
HuR Targeted Nanotherapy for Lung Cancer
HuR 靶向纳米疗法治疗肺癌
  • 批准号:
    8601528
  • 财政年份:
    2013
  • 资助金额:
    --
  • 项目类别:
HuR Targeted Nanotherapy for Lung Cancer
HuR 靶向纳米疗法治疗肺癌
  • 批准号:
    8785610
  • 财政年份:
    2013
  • 资助金额:
    --
  • 项目类别:
HuR Targeted Nanotherapy for Lung Cancer
HuR 靶向纳米疗法治疗肺癌
  • 批准号:
    8440451
  • 财政年份:
    2013
  • 资助金额:
    --
  • 项目类别:

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