脑胰岛素抵抗与阿尔茨海默病的发展-猫眼课题宝

脑胰岛素抵抗与阿尔茨海默病的发展

批准号：

9904967

负责人：

MARK Andrew ESPELAND

金额：

$37.36万

依托单位：

WAKE FOREST UNIVERSITY HEALTH SCIENCES

依托单位国家：

美国

项目类别：

财政年份：

2018

资助国家：

美国

项目状态：

已结题

起止时间：

2018-07-01 至 2021-03-31

来源：

https://reporter.nih.gov/project-details/9904967

关键词：

AKT1 gene AKT2 gene AKT3 gene Administrative Supplement Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk Alzheimer’s disease biomarker Amyloid beta-Protein Antibodies Binding Biological Markers Biological Sciences Biometry Blood Blood specimen Bovine Serum Albumin Brain Brain region Buffers Calcium Case-Control Studies Cells Centrifugation Cerebral cortex Clinical Trials Cognition Cognitive Complex Data Dementia Development Diabetes Mellitus Elderly Energy Intake Excision Exposure to GLUT-3 protein GLUT4 gene Genomics Glucose Glycine Goals Gonadal Steroid Hormones Health Hippocampus (Brain)Hour Human IRS1 gene Impaired cognition In Vitro Incubated Inflammation Insulin Insulin Receptor Insulin Resistance Link Magnesium Magnetic Resonance Imaging Maintenance Measures Memory Metabolic Methods Molecular Mus Neural Cell Adhesion Molecule L1 Neurons Non-Insulin-Dependent Diabetes Mellitus Obesity Overweight Participant Pathology Pathway interactions Patients Performance Peripheral Phosphoric Monoester Hydrolases Phosphoserine Physical activity Plant Resins Plasma Population Precipitation Protease Inhibitor Proteins Publishing Randomized Controlled Clinical Trials Research Personnel Resistance development Risk Role SLC2A1 gene Saline Sampling Sepharose Signal Pathway Skeletal Muscle Streptavidin Surface Suspensions Symptoms System Temperature Testing Thromboplastin Time Tissues Transcript Tyrosine abeta accumulation adjudicate aged angiogenesis brain pathway cell type cerebral atrophy cognitive development cognitive function cognitive performance cohort cost effective design euglycemia exosome improved indexing inhibitor/antagonist insulin sensitivity insulin signaling intercellular communication intravenous administration lifestyle intervention mild cognitive impairment mind body interaction multidisciplinary nanoparticle phosphatase inhibitor preservation relating to nervous system specific biomarkers targeted biomarker tau Proteins weight loss intervention

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英文摘要

Project Summary R01 AG058571 Type 2 diabetes, characterized by insulin resistance in peripheral tissues such as skeletal muscle, increases AD risk. However, it is unclear whether there is a similar, or stronger, relationship between insulin resistance in the brain and AD. The goal of the proposed administrative supplement to Look AHEAD-MIND, while within the original scope, is to further unravel molecular pathways linking the intensive lifestyle intervention to the development of cognitive impairment by examining neural-derived blood exosome biomarkers for brain insulin resistance and Alzheimer's disease (AD) pathologies.

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