Data Core

数据核心

• 批准号: 10461183
• 负责人: MARK Andrew ESPELAND
• 金额: $ 30.78万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10461183
• 关键词: Adult; African American; Alzheimer' s Disease; Alzheimer' s disease risk; American; Applications Grants; Archives; Automobile Driving; Bioinformatics; Biomedical Computing; Biometry; Blood Vessels; Capsicum; Clinical Trials; Cognition; Cognitive; Collaborations; Collection; Communication Research; Communities; Consultations; Data; Data Analyses; Data Management Resources; Data Reporting; Databases; Development; Disease; Education; Educational workshop; Ensure; Family; Fostering; Funding; Genetic; Gerontology; Geroscience; Goals; Health Professional; Image Analysis; Individual; Infrastructure; Interdisciplinary Study; Interest Group; Investments; Manuscripts; Measurement; Measures; Mentors; Metabolic; Methodology; Methods; Mission; Modeling; Multicenter Studies; Pathogenesis; Pathway interactions; Patients; Preparation; Prevention; Prevention strategy; Productivity; Protocols documentation; Publications; Recording of previous events; Reporting; Research; Research Design; Research Infrastructure; Research Personnel; Resources; Role; Science; Secure; Services; Training; United States National Institutes of Health; Vision; Work; analytical method; biomathematics; brain magnetic resonance imaging; career; collaborative environment; data archive; data exchange; data infrastructure; data management; data quality; data resource; experience; forest; improved; meetings; novel; novel strategies; programs; quality assurance; research and development; success; therapeutic development; webinar

Data Management and Statistical Core – Project Summary The mission of the Data Management and Statistical Core (DMSC) is to promote excellence in the Wake Forest ADRC by providing outstanding data management, biomedical computing, and analytical support to ADRC investigators and affiliates. The Wake Forest ADRC has four overarching aims: 1) to establish a comprehensive integrated research infrastructure at Wake Forest focused on identifying the causes of Alzheimer’s disease and related disorders (ADRD) and potential strategies for prevention and treatment; 2) to develop within this infrastructure specialized resources to facilitate research on the role of metabolic and vascular pathways in AD pathogenesis and on targeted development of therapeutic strategies; 3) to optimize the participation of African American adults in research and educational programs to better understand and treat the causes underlying the increased risk of ADRD in these individuals; and 4) to provide education regarding ADRD to researchers, health professionals, patients and their families, and the community at large. To accomplish these objectives, the DMSC will: 1) provide and maintain state-of-the-art resources for data management, study management, and reporting to ensure the highest data quality and study integrity and to increase the efficiency and impact of ADRC research; 2) provide expertise and collaboration in study design, clinical trials, biostatistics and other analytical sciences (including measurement, image analysis, modelling, statistical genetics, bioinformatics, and biomathematics) for Wake Forest ADRC-affiliated projects; 3) develop and maintain efficient and secure platforms for the exchange of data within the Wake Forest ADRC and with NACC, NCRAD, other ADRCs, and ADRD researchers; 4) mine our extensive library of data from major studies of cognition and AD to facilitate efficient study design, provide a platform for pooled analyses, and provide resources to facilitate the development of ADRD researchers, and 5) provide a bridge between ADRD and gerontology/geroscience researchers in the ADRC and the Pepper Older American Independence Center (OAIC) to leverage existing expertise and resources and nurture novel approaches. The DMSC has a breadth of relevant experience, a diverse analytical team, a strong collaborative environment, many extant resources for study management, an extensive archive of cognitive data from many major studies, and a proven robust data management infrastructure. These are the essential facets and notable strengths of our ADRC.

数据管理和统计核心-项目摘要 数据管理和统计核心（DMSC）的使命是促进唤醒卓越 森林ADRC通过提供出色的数据管理，生物医学计算和分析支持， ADRC调查员和附属机构。维克森林ADRC有四个首要目标：1）建立一个 维克森林的一个全面综合研究基础设施，重点是确定 阿尔茨海默病及相关疾病（ADRD）和潜在的预防和治疗策略; 2） 在这一基础设施内开发专门的资源，以促进对代谢和 血管通路在AD发病机制和有针对性的发展治疗策略; 3）优化 非裔美国成年人参与研究和教育计划，以更好地了解和 治疗这些个体ADRD风险增加的根本原因;以及4）提供教育 向研究人员、卫生专业人员、患者及其家属以及整个社区提供关于ADRD的信息。 为了实现这些目标，DMSC将：1）提供和维护最先进的数据资源 管理、研究管理和报告，以确保最高的数据质量和研究完整性， 提高ADRC研究的效率和影响; 2）提供研究设计方面的专业知识和协作， 临床试验，生物统计学和其他分析科学（包括测量，图像分析，建模， 统计遗传学，生物信息学和生物数学）为维克森林ADRC附属项目; 3）开发 并维持有效和安全的平台，用于在维克森林ADRC内交换数据，并与 NACC，NCRAD，其他ADRC和ADRD研究人员; 4）挖掘我们广泛的数据库，从主要的 认知和AD的研究，以促进有效的研究设计，为汇总分析提供平台， 提供资源以促进ADRD研究人员的发展，以及5）提供ADRD之间的桥梁 以及ADRC和Pepper Older American Independence Center的老年学/老年科学研究人员 （内审办）利用现有的专门知识和资源，并培育新的方法。DMSC有一个广泛的 拥有丰富的相关经验、多元化的分析团队、强大的协作环境、众多的现有资源 对于研究管理，来自许多主要研究的认知数据的广泛存档，以及经过验证的 数据管理基础设施。这些都是发展检讨委员会的重要范畴和显著优点。