LA-Aging Diversity Supplement

项目摘要/摘要 总体--项目摘要 肥胖和2型糖尿病被描述为加速衰老。已经有过无数次的尝试 数十年来开发和验证加速老化的可测量结构。我们已经进行了研究 由NIDDK资助的两个之前成功的多样性补充支持，以开发和应用赤字 以累积脆弱指数为前8年的前瞻性队列随访，时间跨度为 所有参与者都被分配到积极的干预措施中。这是一项富有成效的事业。我们有 发布消息称： 前瞻性密集生活方式干预(ILI)创建了一种缓冲，以应对FI的增加，大致 对照组的年龄与一年的年龄成正比 在基线FI相对较低的参与者中，ILI导致较低的主要 心血管疾病事件，然而，在基线FI得分最高的参与者中，ILI 与心血管事件发生率的增加有关 的前瞻ILI在保留所有的认知功能方面同样无效 基线FI 在8年中FI增加得更多与随后的死亡率和 身体和认知功能的轨迹较差 我们建议利用提供的大量数据资源进行一系列二级数据分析 展望队列，1)扩大赤字积累FI最初是由展望通过 第8年至展望延期结束(第18年)，产生FIE；2)制定统计数据 在19-23年的后续行动中，将此FI与由父母基金(LA-Aging)开发的FI连接起来 (FIA)；以及3)研究FIE的发展轨迹与老年综合征患病率之间的关系 超前老龄化研究。如果成功，这个项目将提供一个经过验证的长期生物老化的标志 可以在临床试验中作为结果衡量标准，也可以作为确定老年人延缓衰老因素的工具 患有2型糖尿病和肥胖症的成年人。 这个项目的一个补充目标是进一步发展乔纳森·罗斯，一个有前途的 温斯顿-塞勒姆州立大学的本科生，这是一所历史上黑人的公立研究型大学。他的 主要导师将是马克·埃斯佩兰博士，他经验丰富，非常适合担任这一角色。我们对PA做出回应- 21-071促进健康相关研究多样性的研究补充资料。已计划的摘要 对展望计划的贡献。本申请附于1U01AG073697-01：健康行动 糖尿病(展望未来)延长随访(LA-Aging)马克·A·埃斯佩兰，博士，双重校长 调查员。

Project Summary/Abstract OVERALL – PROJECT SUMMARY Obesity and type 2 diabetes are described as accelerators aging. There have been numerous attempts across decades to develop and validate measureable constructs for accelerated aging. We have conducted research supported by two prior successful NIDDK-funded diversity supplements to develop and apply deficit accumulation frailty indices to the first 8 years of follow-up in the Look AHEAD cohort, the span of time when all participants were assigned to active interventions. This has been a productive enterprise. We have published that:  The Look AHEAD intensive lifestyle intervention (ILI) created a buffer against increases in FI, roughly proportional to one year of aging in the control group  Among participants with relatively low FI at baseline, the ILI resulted in lower incidence of major cardiovascular disease events, however among participants with the highest FI scores at baseline, the ILI was associated with an increased incidence of cardiovascular events  The Look AHEAD ILI was equally ineffectual in preserving cognitive function across the full range of baseline FI  Greater increases in FI across 8 years was associated with subsequent increased risk for mortality and poorer trajectories of physical and cognitive function We propose to conduct a series of secondary data analyses, using the extensive data resources provided by the Look AHEAD cohort, 1) to extend the deficit accumulation FI originally developed by Look AHEAD through year 8 to the close-out of the Look AHEAD Extension (Year 18), producing FIE; 2) to develop a statistical bridge linking this FI with one being developed by the parent grant (LA-Aging) for years 19-23 of follow-up (FIA); and 3) to examine how trajectories of FIE are related to the prevalence of geriatric syndromes in the Look AHEAD Aging study. If successful, this project will provide a validated marker of long-term biological aging that can serve as an outcome measure in clinical trials and a tool for identifying factors that slow aging among older adults with type 2 diabetes and obesity. A complementary goal of this project is to further the development of Johnathan Ross, a promising undergraduate student at Winston-Salem State University, a historically black public research university. His primary mentor will be Dr. Mark Espeland, who is experienced and well-suited for this role. We respond to PA- 21-071 Research Supplements to Promote Diversity in Health-Related Research. Summary of Planned Contributions to the Look AHEAD Program. This request is attached to 1U01AG073697-01: Action for Health in Diabetes (Look AHEAD) Extended Follow-up (LA-Aging) Mark A. Espeland, PhD, Dual Principal Investigator.