Diversity Supplement: Preschooler emotion regulation in the context of maternal borderline personality disorder

多样性补充：母亲边缘型人格障碍背景下学龄前儿童的情绪调节

• 批准号: 9901326
• 负责人: Maureen Zalewski
• 金额: $ 4.2万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-01 至 2022-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9901326
• 关键词: Attention; Biomedical Research; Borderline Personality Disorder; Child; Development; Dialectical behavior therapy; Emotions; Family; Future; Goals; Grant; Growth; Income; Interpersonal Relations; Intervention; Knowledge; Laboratories; Longevity; Measures; Mental Health; Mental disorders; Methods; Modeling; Mothers; Nursery Schools; Oregon; Outcome Measure; Pathway interactions; Pennsylvania; Process; Regulation; Research Training; Risk; Services; Socialization; Testing; Time; United States National Institutes of Health; biobehavior; emotion regulation; improved; offspring; severe mental illness; skills; skills training; suicidal behavior; tool

This diversity supplement supports R01MH111758-01A1 to promote Ana Hernandez’s research, training, and professional development. The grant regards mothers with borderline personality disorder (BPD), a serious mental illness characterized by extreme emotions, chaotic interpersonal relationships, suicidal behaviors, and a poor sense of self. Offspring of mothers with BPD are at an elevated risk for developing mental illness across the lifespan. Difficulty managing emotions are a hallmark feature of BPD, and yet the ability to do so is necessary for responding effectively to childrens’ emotions. This process is called maternal emotion socialization, which has a major impact on how children develop their own emotion regulation (ER) skills. ER develops rapidly during preschool and deficits in preschool ER are recognized as underlying future mental disorders. This proposal will test a model examining the extent to which maternal ER and emotion socialization impact child ER, which may be a significant pathway by which mental health problems are transmitted to offspring of mothers with BPD. This proposal will leverage Dialectical Behavior Therapy (DBT) Skills training, a robust and effective method for improving ER as a tool to change maternal ER in mothers with BPD. By completing multiple assessments of biobehavioral markers of child and mother ER, this study is poised to uncover a potentially modifiable pathway by which these offspring are at risk. Specifically, we will conduct a stratified RCT of DBT Skills for mothers with BPD who have preschoolers (36-48 mos). A total of 270 dyads will be collected in Eugene, Oregon and Pittsburgh Pennsylvania, with 90 pairs in each of three groups: children who have mothers with BPD who receive DBT Skills, children who have mothers with BPD who receive Family Services as Usual (FSU), and children who have non-disordered mothers, matched on income, with this final group only participating in assessments (as to quantify normative ER growth). All children will be assessed 4 times every 4-months, with the first assessment occurring prior to treatment assignment. We will use a biobehavioral laboratory battery to measure child ER, assessing emotion understanding, strategy use, attention regulation, inhibitory control, and parasympathetic regulation. In mothers, we will employ a similar multi-method approach to assess emotion acceptance, strategy use, recognition, and parasympathetic regulation. Finally, during each laboratory assessment, we will observe mother’s ability to effectively respond to children’s negative emotions. Growth curve modeling will chart child ER trajectories for all 3 groups so that we can compare child ER growth as a function of: group status (DBT Skills vs. FSU vs. income matched, non-disordered controls), changes in maternal ER, and changes in maternal emotion socialization. Findings from this proposal will identify a modifiable pathway by which offspring of mothers with BPD are at risk, determine the extent to which child ER can be restored by treating mothers, and will be the first DBT Skills trial to measure outcomes in offspring.

这一多样性补充支持R01MH111758-01A1以促进Ana Hernandez的研究， 培训和专业发展。这笔赠款适用于患有边缘性人格障碍(BPD)的母亲， 一种严重的精神疾病，以极端情绪、混乱的人际关系、自杀倾向为特征 行为不端，自我感觉不佳。患有BPD的母亲的后代患BPD的风险更高 终生精神疾病。难以管理情绪是BPD的一个标志特征，但 这样做的能力对于有效地应对儿童的情绪是必要的。这一过程被称为母性 情绪社会化，这对儿童如何发展自己的情绪调节(ER)有重要影响 技能。ER在学龄前发展迅速，学龄前ER缺陷被认为是潜在的未来 精神错乱。这项提议将测试一个模型，测试母亲ER和情绪的程度 社会化影响儿童ER，这可能是心理健康问题发生的重要途径 传播给患有BPD的母亲的后代。该提案将利用辩证行为疗法(DBT) 技能培训是改善ER的有力而有效的方法，作为改变母亲ER的工具 每桶。通过完成对孩子和母亲ER生物行为标记物的多项评估，这项研究是 准备揭示一条潜在的可修改的途径，通过这条途径，这些后代处于危险之中。具体来说，我们将 为有学龄前儿童(36-48个月)的患有BPD的母亲进行DBT技能分层RCT。总计 270对情侣将在俄勒冈州尤金和宾夕法尼亚州匹兹堡收集，三个城市中的每一个都有90对 小组：母亲患有BPD并接受DBT技能的儿童，母亲患有BPD的儿童 像往常一样接受家庭服务(FSU)的孩子和母亲没有精神障碍的孩子配对 收入，这最后一组只参加评估(以量化标准的ER增长)。全 儿童将每4个月接受4次评估，第一次评估在治疗前进行 任务。我们将使用生物行为实验室的电池来测量儿童ER，评估情绪 理解、策略使用、注意调节、抑制控制和副交感调节。在……里面 对于母亲，我们将使用类似的多方法来评估情绪接受、策略使用、 认同感和副交感神经调节。最后，在每次实验室评估期间，我们将观察 母亲有效应对孩子负面情绪的能力。生长曲线建模将绘制孩子 所有三个组的ER轨迹，以便我们可以比较儿童ER生长作为以下因素的函数：组状态(DBT 技能、FSU、收入匹配、非无序对照)，母亲ER的变化，以及 母性情感社会化。这项提案的发现将确定一种可修改的途径，即后代 患有BPD的母亲处于危险之中，确定通过治疗母亲可以在多大程度上恢复儿童ER， 这将是第一个衡量后代结果的DBT技能试验。