Diversity Supplement: Preschooler emotion regulation in the context of maternal borderline personality disorder

多样性补充：母亲边缘型人格障碍背景下学龄前儿童的情绪调节

• 批准号: 9901326
• 负责人: Maureen Zalewski
• 金额: $ 4.2万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-01 至 2022-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9901326
• 关键词: Attention; Biomedical Research; Borderline Personality Disorder; Child; Development; Dialectical behavior therapy; Emotions; Family; Future; Goals; Grant; Growth; Income; Interpersonal Relations; Intervention; Knowledge; Laboratories; Longevity; Measures; Mental Health; Mental disorders; Methods; Modeling; Mothers; Nursery Schools; Oregon; Outcome Measure; Pathway interactions; Pennsylvania; Process; Regulation; Research Training; Risk; Services; Socialization; Testing; Time; United States National Institutes of Health; biobehavior; emotion regulation; improved; offspring; severe mental illness; skills; skills training; suicidal behavior; tool

This diversity supplement supports R01MH111758-01A1 to promote Ana Hernandez’s research, training, and professional development. The grant regards mothers with borderline personality disorder (BPD), a serious mental illness characterized by extreme emotions, chaotic interpersonal relationships, suicidal behaviors, and a poor sense of self. Offspring of mothers with BPD are at an elevated risk for developing mental illness across the lifespan. Difficulty managing emotions are a hallmark feature of BPD, and yet the ability to do so is necessary for responding effectively to childrens’ emotions. This process is called maternal emotion socialization, which has a major impact on how children develop their own emotion regulation (ER) skills. ER develops rapidly during preschool and deficits in preschool ER are recognized as underlying future mental disorders. This proposal will test a model examining the extent to which maternal ER and emotion socialization impact child ER, which may be a significant pathway by which mental health problems are transmitted to offspring of mothers with BPD. This proposal will leverage Dialectical Behavior Therapy (DBT) Skills training, a robust and effective method for improving ER as a tool to change maternal ER in mothers with BPD. By completing multiple assessments of biobehavioral markers of child and mother ER, this study is poised to uncover a potentially modifiable pathway by which these offspring are at risk. Specifically, we will conduct a stratified RCT of DBT Skills for mothers with BPD who have preschoolers (36-48 mos). A total of 270 dyads will be collected in Eugene, Oregon and Pittsburgh Pennsylvania, with 90 pairs in each of three groups: children who have mothers with BPD who receive DBT Skills, children who have mothers with BPD who receive Family Services as Usual (FSU), and children who have non-disordered mothers, matched on income, with this final group only participating in assessments (as to quantify normative ER growth). All children will be assessed 4 times every 4-months, with the first assessment occurring prior to treatment assignment. We will use a biobehavioral laboratory battery to measure child ER, assessing emotion understanding, strategy use, attention regulation, inhibitory control, and parasympathetic regulation. In mothers, we will employ a similar multi-method approach to assess emotion acceptance, strategy use, recognition, and parasympathetic regulation. Finally, during each laboratory assessment, we will observe mother’s ability to effectively respond to children’s negative emotions. Growth curve modeling will chart child ER trajectories for all 3 groups so that we can compare child ER growth as a function of: group status (DBT Skills vs. FSU vs. income matched, non-disordered controls), changes in maternal ER, and changes in maternal emotion socialization. Findings from this proposal will identify a modifiable pathway by which offspring of mothers with BPD are at risk, determine the extent to which child ER can be restored by treating mothers, and will be the first DBT Skills trial to measure outcomes in offspring.

该多样性补充支持R 01 MH 111758 - 01 A1促进安娜埃尔南德斯的研究， 培训和专业发展。该补助金适用于患有边缘性人格障碍（BPD）的母亲， 一种严重的精神疾病，其特征是极端的情绪，混乱的人际关系，自杀 行为和自我意识差。患有BPD的母亲的后代患BPD的风险增加， 精神疾病的影响。难以管理情绪是BPD的标志性特征，然而， 这样做的能力是有效应对儿童情绪的必要条件。这个过程被称为母性 情绪社会化，这对儿童如何发展自己的情绪调节（ER）有重要影响 skills. ER在学龄前迅速发展，学龄前ER缺陷被认为是潜在的未来 精神障碍这项建议将测试一个模型，研究母亲的ER和情绪在多大程度上 社会化影响儿童ER，这可能是心理健康问题 会传染给患有BPD的母亲的后代该提案将利用辩证行为疗法（DBT） 技能培训是改善ER的一种强大而有效的方法，可作为改变母亲ER的工具， 波士顿警局通过对儿童和母亲ER的生物行为标志物进行多次评估，本研究 准备揭示一个潜在的可改变的途径，通过这个途径，这些后代处于危险之中。具体来说，我们将 对有学龄前儿童（36-48个月）的BPD母亲进行DBT技能分层RCT。共 在俄勒冈州的尤金和宾夕法尼亚州的匹兹堡将收集270对二人组，其中三对各有90对 组：母亲患有BPD并接受DBT技能的儿童，母亲患有BPD的儿童 谁接受家庭服务作为父母（FSU），和儿童谁有非疾病的母亲，匹配 最后一组仅参与评估（以量化标准ER增长）。所有 儿童将每4个月进行4次评估，第一次评估在治疗前进行 派任我们将使用生物行为实验室电池来测量儿童ER，评估情绪 理解、策略使用、注意力调节、抑制控制和副交感神经调节。在 母亲，我们将采用类似的多方法方法来评估情绪接受，策略使用， 识别和副交感神经调节。最后，在每次实验室评估期间，我们将观察 母亲有效应对孩子负面情绪的能力。成长曲线建模将图表儿童 所有3组的ER轨迹，以便我们可以比较儿童ER生长作为以下函数：组状态（DBT 技能vs. FSU vs.收入匹配，非疾病对照），母亲ER的变化， 母亲情感社会化这项提案的发现将确定一种可改变的途径， 的BPD母亲有风险，确定通过治疗母亲可以恢复儿童ER的程度， 这将是第一个DBT技能试验，以衡量后代的结果。