Western States Node of the National Drug Abuse Treatment Clinical Trials Network

项目总结/摘要 国家药物滥用治疗临床试验网络（CTN）的西部各州（WS）节点促进 通过继续参与CTN，提供循证药物滥用预防和治疗服务。的 节点1）设计和实施基于证据的成瘾治疗的临床试验，通过快速 与NIDA和CTN合作招募不同的研究参与者，2）产生同行评审 与治疗提供者和其他节点合作出版物，以及3）使用CTN作为平台， 培训、传播和研究应用。区域研究和培训中心包括 来自俄勒冈州健康与科学中心和加州大学旧金山弗朗西斯科的优秀教师和工作人员， 以及提供综合初级保健和物质使用障碍的附属医疗保健合作伙伴的领导人 治疗该节点创建于2010年，是两个CTN节点的混合体-加利福尼亚州-亚利桑那州和 俄勒冈州/夏威夷（CTN的特许成员）。节点是非常成功的，在目前的奖项， 参与10项CTN试验，共同领导其中两项，领导一项;报告CTN主要研究的结果， 辅助和研究使用CTN平台在100+出版物，并积极传播证据- 在200个演示文稿的基础上。节点研究人员还寻求并获得了10项研究的奖项， 使用CTN作为研究平台。八个WS Node医疗保健计划招募了1，300多名员工 参与CTN研究。在即将到来的赠款期间，该节点将扩大到包括三个国家和 区域初级保健和艾滋病毒初级保健研究网络：OCHIN、艾滋病毒研究网络和 俄勒冈州农村实践研究网络。该节点保留了核心成瘾治疗中心 在CTN协议方面经验丰富，并利用其与初级保健的联系：Adapt（罗斯堡，OR），CODA （波特兰，OR）HealthRIGHT 360（弗朗西斯科，CA），拉弗龙特拉（图森，AZ），奈良（波特兰，OR），和 Signal Behavioral Health Network（Denver，CO）.节点的研究议程提出了研究概念， 评估三项战略，以整合和加强医疗机构内的成瘾治疗。研究1 建立了一个HCV感染的患者登记处，并测试了酒精使用的多接触简短干预。研究2 扩大了候选治疗性艾滋病毒疫苗的注册测试。研究3，反向整合测试（初级 成瘾治疗环境中的护理临床医生），评估纳洛酮的分布和教育，以减少致命的 和非致命性阿片类药物过量，并测量对恢复使用的影响。最后，WS节点继续使用 CTN作为培训、传播和研究应用的平台。该节点有可能 在未来几年加快推进综合初级保健和戒毒工作。

PROJECT SUMMARY / ABSTRACT The Western States (WS) Node of the National Drug Abuse Treatment Clinical Trials Network (CTN) promotes evidence-based drug abuse prevention and treatment services through continued participation in the CTN. The Node 1) designs and implements clinical trials of evidence-based treatments of addiction through rapid recruitment of diverse study participants in partnership with NIDA and the CTN, 2) generates peer-reviewed publications in collaboration with treatment providers and other nodes, and 3) uses the CTN as a platform for training, dissemination, and research applications. The Regional Research and Training Center includes talented faculty and staff from Oregon Health & Science Center and University of California, San Francisco as well as leaders of affiliated healthcare partners providing integrated primary care and substance use disorder treatment. The Node was created in 2010 as an amalgam of two CTN Nodes--California-Arizona and Oregon/Hawaii (a charter member of the CTN). The Node was highly successful, during the current award, participating in 10 CTN trials, co-leading two of these and leading one; reporting results of CTN main studies, ancillary, and research using the CTN platform in 100+ publications, and actively disseminating evidence- based practices in 200 presentations. Node investigators also sought and received awards for 10 studies that used the CTN as a platform for research. Eight WS Node healthcare programs recruited over 1,300 participants into CTN studies. In the coming grant period the Node expands to include three national and regional primary care and HIV primary care research networks: OCHIN, the HIV Research Network, and the Oregon Rural Practice-Based Research Network (ORPRN). The Node retains core addiction treatment centers experienced in CTN protocols and exploits their links with primary care: Adapt (Roseburg, OR), CODA (Portland, OR) HealthRIGHT 360 (San Francisco, CA), La Frontera (Tucson, AZ), NARA (Portland, OR), and Signal Behavioral Health Network (Denver, CO). The Node's research agenda proposes study concepts that evaluate three strategies to integrate and enhance addiction treatment within healthcare settings. Study 1 builds a patient registry for HCV infection and tests a multi-contact brief intervention for alcohol use. Study 2 extends the registry testing a candidate therapeutic HIV vaccine. Study 3, a test of reverse integration (primary care clinicians in addiction treatment settings), assesses naloxone distribution and education to reduce fatal and nonfatal opioid overdoses and measures impact on return to use. Finally the WS Node continues to use the CTN as a platform for training, dissemination, and research applications. The Node has the potential to accelerate the advancement of integrated primary care and addiction in the coming years.