Western States Node of the National Drug Abuse Treatment Clinical Trials Network

项目摘要/摘要 国家药物滥用治疗临床试验网络(CTN)的西部州(WS)节点促进 通过继续参加反恐网络，提供循证药物滥用预防和治疗服务。这个 节点1)设计并实施基于证据的成瘾治疗的临床试验 与NIDA和CTN合作招募不同的研究参与者，2)产生同行审查 与治疗提供者和其他节点合作的出版物，以及3)使用CTN作为平台 培训、传播和研究应用。区域研究和培训中心包括 来自俄勒冈健康与科学中心和加州大学旧金山分校的有才华的教职员工 以及提供综合初级保健和物质使用障碍的附属医疗合作伙伴的领导人 治疗。该节点创建于2010年，由两个CTN节点组成--加利福尼亚-亚利桑那州和 俄勒冈州/夏威夷(CTN的创始成员)。Node非常成功，在目前的奖项中， 参与CTN试验10项，共同牵头其中两项，牵头一项；报告CTN主要研究结果， 利用CTN平台在100种出版物上进行辅助和研究，并积极传播证据-- 基于200个演示文稿的实践。节点研究人员还为以下10项研究寻求并获得了奖项 利用CTN作为研究的平台。8个WS Node医疗保健计划招募了1300多人 参与CTN研究。在即将到来的赠款期间，该节点将扩大到包括三个国家和 区域初级保健和艾滋病毒初级保健研究网络：人道协调厅、艾滋病毒研究网络和 俄勒冈州农村实践研究网络(ORPRN)。Node保留了核心的成瘾治疗中心 在CTN方案方面经验丰富，并利用它们与初级保健的联系：Adapt(Roseburg，OR)，CODA (俄勒冈州波特兰)HealthRight 360(加利福尼亚州旧金山)、La Frontera(亚利桑那州图森)、NARA(俄勒冈州波特兰)和 信号行为健康网络(科罗拉多州丹佛市)。该节点的研究议程提出了以下研究概念 评估在医疗保健环境中整合和加强成瘾治疗的三项战略。研究1 建立丙型肝炎病毒感染的患者登记表，并测试酒精使用的多接触短暂干预。研究2 延长测试候选治疗性艾滋病毒疫苗的登记范围。研究3，反向整合检验(初级 在成瘾治疗环境中护理临床医生)，评估纳洛酮的分布和教育以减少死亡 和非致命的阿片类药物过量和措施对重新使用的影响。最后，WS节点将继续使用 CTN作为培训、传播和研究应用的平台。该节点有可能 在未来几年加快推进综合初级保健和成瘾。

PROJECT SUMMARY / ABSTRACT The Western States (WS) Node of the National Drug Abuse Treatment Clinical Trials Network (CTN) promotes evidence-based drug abuse prevention and treatment services through continued participation in the CTN. The Node 1) designs and implements clinical trials of evidence-based treatments of addiction through rapid recruitment of diverse study participants in partnership with NIDA and the CTN, 2) generates peer-reviewed publications in collaboration with treatment providers and other nodes, and 3) uses the CTN as a platform for training, dissemination, and research applications. The Regional Research and Training Center includes talented faculty and staff from Oregon Health & Science Center and University of California, San Francisco as well as leaders of affiliated healthcare partners providing integrated primary care and substance use disorder treatment. The Node was created in 2010 as an amalgam of two CTN Nodes--California-Arizona and Oregon/Hawaii (a charter member of the CTN). The Node was highly successful, during the current award, participating in 10 CTN trials, co-leading two of these and leading one; reporting results of CTN main studies, ancillary, and research using the CTN platform in 100+ publications, and actively disseminating evidence- based practices in 200 presentations. Node investigators also sought and received awards for 10 studies that used the CTN as a platform for research. Eight WS Node healthcare programs recruited over 1,300 participants into CTN studies. In the coming grant period the Node expands to include three national and regional primary care and HIV primary care research networks: OCHIN, the HIV Research Network, and the Oregon Rural Practice-Based Research Network (ORPRN). The Node retains core addiction treatment centers experienced in CTN protocols and exploits their links with primary care: Adapt (Roseburg, OR), CODA (Portland, OR) HealthRIGHT 360 (San Francisco, CA), La Frontera (Tucson, AZ), NARA (Portland, OR), and Signal Behavioral Health Network (Denver, CO). The Node's research agenda proposes study concepts that evaluate three strategies to integrate and enhance addiction treatment within healthcare settings. Study 1 builds a patient registry for HCV infection and tests a multi-contact brief intervention for alcohol use. Study 2 extends the registry testing a candidate therapeutic HIV vaccine. Study 3, a test of reverse integration (primary care clinicians in addiction treatment settings), assesses naloxone distribution and education to reduce fatal and nonfatal opioid overdoses and measures impact on return to use. Finally the WS Node continues to use the CTN as a platform for training, dissemination, and research applications. The Node has the potential to accelerate the advancement of integrated primary care and addiction in the coming years.