Investigating peripheral nerve stimulation as a treatment for female sexual dysfunction

研究周围神经刺激治疗女性性功能障碍

• 批准号: 9900846
• 负责人: Lauren Leigh Zimmerman
• 金额: --
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2020-05-02
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9900846
• 关键词: Acute; Adult; Affect; Arousal; Automobile Driving; Behavior; Behavioral; Bladder Control; Bladder Diseases; Bladder Dysfunction; Blood flow; Caliber; Chronic; Clinical Treatment; Complex; Control Animal; Disease; Electric Stimulation; Electrodes; Erectile dysfunction; Female; Frequencies; Genital system; Genitalia; Goals; Hormones; Implant; Incontinence; Industry; Investigation; Laser-Doppler Flowmetry; Lubrication; Methods; Modeling; Monitor; Motivation; Nerve; Neuraxis; Operative Surgical Procedures; Orgasm; Overactive Bladder; Pain; Patients; Pelvis; Peripheral; Peripheral Nerve Stimulation; Pharmaceutical Preparations; Pharmacologic Substance; Physiological; Pre-Clinical Model; Rattus; Research; Research Personnel; Sex Behavior; Sex Functioning; Sexual Arousal; Sexual Dysfunction; Structure of tibial nerve; Symptoms; Techniques; Testing; Time; Vagina; Video Recording; Woman; blood perfusion; effective therapy; insight; male; men; neural circuit; neuromechanism; neuroregulation; novel; preclinical study; response; treatment planning

Project Summary The goal of this study is to investigate peripheral nerve stimulation as a treatment for female sexual dysfunction (FSD). FSD affects a massive number of women in the world, yet investigations into treatment options have been limited. A promising treatment avenue is neuromodulation. Neuromodulation is an increasingly expanding clinical treatment option to treat a wide variety of disorders. In studies of men and women receiving neuromodulation therapy for treatment of bladder dysfunction (in the form of sacral neuromodulation and percutaneous tibial nerve stimulation), both men and women noted an unintended improvement in sexual functioning. This study is driven by the hypothesis that similar stimulation techniques and paradigms can be used to specifically target sexual functioning in women with FSD and cause significant improvements. This effect has been demonstrated in preliminary studies within this lab, where it has been proven possible to drive increases in low frequency oscillations in vaginal blood flow in anesthetized rats. In this proposed study, researchers will be further investigating the optimal parameters for driving acute genital arousal in female rats. Furthermore, researchers will be evaluating the effect of peripheral nerve stimulation on sexual behavior. The hypothesis is that by stimulating nerves that innervate the sexual genitalia and drive genital arousal, the stimulation will increase sexually receptive behavior. This will be evaluated through video of recording of female rats interacting with male rats during and after stimulation. This research aims to demonstrate the potential for peripheral nerve stimulation to serve as an effective treatment for female sexual dysfunction.

项目摘要 本研究的目的是研究周围神经刺激作为一种治疗糖尿病的方法。 女性性功能障碍(FSD)。FSD影响着世界上大量的女性，但 对治疗选择的调查一直有限。一个很有前途的治疗途径是 神经调节。神经调节是一种日益扩大的临床治疗选择 各种各样的疾病。在对接受神经调节治疗的男性和女性的研究中 膀胱功能障碍(以神经调节和经皮胫骨穿刺术为主)的治疗 神经刺激)，男性和女性都注意到了性功能的意外改善。 这项研究是由一种假设驱动的，即类似的刺激技术和范式可以 用于针对患有FSD的女性的性功能，并导致显著的 改进。这一效应已在本实验室的初步研究中得到证明，其中 已被证明有可能推动阴道血流低频振荡的增加 麻醉大鼠。在这项拟议的研究中，研究人员将进一步研究 雌性大鼠急性生殖器唤醒的驱动参数。此外，研究人员将被 评价周围神经刺激对性行为的影响。假设是通过 刺激神经来神经性生殖器并驱动生殖器的唤醒，刺激将 增强性接受行为。这将通过录制女性的视频进行评估 大鼠在刺激过程中和刺激后与雄性大鼠相互作用。这项研究旨在证明 周围神经刺激可能成为女性性行为的有效治疗手段 功能障碍。