Manufacture and Testing of Next Generation Orthopaedic Implants Harnessing Periosteum's Regenerative Power

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Tissue defects, e.g. due to trauma or tumor removal, are too large to heal without reconstructive surgery. Complications associated with defect repair may diminish the patient's quality of life and productivity, posing significant medical and psychosocial costs. Here we propose a plan to define technical specifications for next generation, 'smart' orthopaedic implants that deliver cells and the signals they need to build new tissue using nature's paradigms.