Manufacture and Testing of Next Generation Orthopaedic Implants Harnessing Periosteum's Regenerative Power

组织缺陷，例如由于创伤或肿瘤切除，如果不进行重建手术，就太大而无法愈合。与缺陷修复相关的并发症可能会降低患者的生活质量和生产力，造成巨大的医疗和心理成本。在这里，我们提出了一项计划，以定义下一代“智能”骨科植入物的技术规格，这种植入物可以传递细胞和信号，这些细胞和信号需要使用自然的范例来构建新的组织。

Tissue defects, e.g. due to trauma or tumor removal, are too large to heal without reconstructive surgery. Complications associated with defect repair may diminish the patient's quality of life and productivity, posing significant medical and psychosocial costs. Here we propose a plan to define technical specifications for next generation, "smart" orthopaedic implants that deliver cells and the signals they need to build new tissue using nature's paradigms.