Project 3: Understanding and optimizing the potential public health impact of a gonococcal vaccine

项目 3：了解和优化淋球菌疫苗的潜在公共卫生影响

• 批准号: 9899931
• 负责人: Kate Louise Seib
• 金额: $ 40.81万
• 依托单位: GEORGIA STATE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9899931
• 关键词: Alleles; Antigen Targeting; Antigens; Antimicrobial Resistance; Clinical; Clinical Trials; Data; Direct Costs; Disease; Engineering; Epidemiology; Evaluation; Face; Facilities and Administrative Costs; Formulation; Funding; Future; Goals; Gonorrhea; HIV; Human Papilloma Virus Vaccine; Human Papillomavirus; Incidence; Industry; Infection; Infertility; Intervention; Interview; Investments; Kenya; Malignant Neoplasms; Maps; Modeling; Multi-Drug Resistance; Neisseria gonorrhoeae; Neonatal; Nutrient; Outcome; Participant; Pathway interactions; Pelvic Inflammatory Disease; Perception; Phenotype; Population; Prevalence; Public Health; Resistance; Risk; Scientific Advances and Accomplishments; Sex Behavior; Sexually Transmitted Agents; Sexually Transmitted Diseases; Societies; Superbug; Surveys; Target Populations; Teenagers; Vaccine Design; Vaccines; Variant; adverse pregnancy outcome; base; clinical development; cost effectiveness; genomic epidemiology; girls; high risk population; mathematical model; mucosal site; pre-clinical; research clinical testing; risk perception; transmission process; uptake; vaccination strategy; vaccine candidate; vaccine development

Project Summary Neisseria gonorrhoeae (Ngo), the causative agent of the sexually transmitted infection (STI) gonorrhea, is a major public health problem worldwide. The clinical outcomes of gonococcal infection range from asymptomatic infection to severe sequelae that include pelvic inflammatory disease, adverse pregnancy outcomes, neonatal complications and infertility. Infection with Ngo also increases the risk of acquiring and transmitting HIV. The increasing incidence of gonococcal infection and the emergence of multidrug resistant ‘superbug’ strains of Ngo make it clear that a vaccine-based intervention is urgently needed. In this project our overall goal is to gather the data required to understand any potential barriers to the widespread implementation of a gonococcal vaccine, to determine what information might increase uptake, and to identify the vaccine features and vaccination strategy that will have the maximum impact on reducing the prevalence of gonorrhea. These studies are highly significant given that the ability to rapidly evaluate and implement a gonococcal vaccine, once available, is essential. The specific aims are: AIM 1: Describe the distribution and transmission of Ngo with different phenotypes, and determine variability among vaccine targets. AIM 2: Among various populations, describe understanding of gonococcal disease and perceptions of risk as well as assess acceptance of a gonococcal vaccine. AIM 3: Model the potential impact of different vaccine formulations and different target populations to guide gonococcal vaccine development and implementation.

项目摘要 淋病奈瑟菌（Ngo）是性传播感染（STI）淋病的病原体，是一种 全球性的重大公共卫生问题。淋球菌感染的临床结果从无症状 感染到严重后遗症，包括盆腔炎、不良妊娠结局、新生儿 并发症和不孕症。感染非政府组织也会增加感染和传播艾滋病毒的风险。的 淋球菌感染的发病率增加，出现了耐多药的“超级细菌”菌株 明确表示迫切需要基于疫苗的干预措施。 在这个项目中，我们的总体目标是收集所需的数据，以了解任何潜在的障碍， 广泛实施淋球菌疫苗，以确定哪些信息可能会增加接种， 确定疫苗的特点和疫苗接种策略，最大限度地减少 淋病的流行。 这些研究是非常重要的，因为快速评估和实施淋病疫苗的能力， 一旦有了疫苗，就必不可少。 具体目标是： 目的1：描述不同表型Ngo的分布和传播，并确定变异性 疫苗的目标。 目的2：在不同人群中，描述对淋球菌疾病的理解和对风险的看法， 以及评估淋球菌疫苗的接受程度。 目的3：建立不同疫苗配方和不同目标人群的潜在影响模型， 淋球菌疫苗的开发和实施。