Molecular Biology/Molecular Genetics (Core C)
分子生物学/分子遗传学(核心 C)
基本信息
- 批准号:9901512
- 负责人:
- 金额:$ 22.94万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-04-01 至 2021-03-31
- 项目状态:已结题
- 来源:
- 关键词:AdipocytesAnimal ModelApplications GrantsAreaBackBasic ScienceBioinformaticsBiologicalBiological AssayBiopsyBrainCRISPR/Cas technologyCell Differentiation processCell LineCell LineageCell modelCellsClinical ResearchCloningCollaborationsCommunitiesConsultationsCore FacilityDNADNA sequencingDataData AnalysesDerivation procedureEmerging TechnologiesEquipmentFacultyFosteringGap JunctionsGene ExpressionGenerationsGenetic TechniquesGenomicsGenotypeGoalsGrantHuman ResourcesHypothalamic structureLaboratoriesLeptinLibrariesLiverManuscriptsMediationMedicalModernizationMolecularMolecular BiologyMolecular GeneticsMusMutationNeurosciencesNew YorkObesityPathogenesisPatientsPeer ReviewPerformancePhenotypePhylogenetic AnalysisPhysiologicalPlayPreparationPriceProductivityProteomicsProtocols documentationPublicationsReagentRecording of previous eventsReferral and ConsultationResearchResearch ActivityResearch DesignResearch PersonnelResearch Project GrantsResearch SupportResourcesRibosomal RNARoleSample SizeServicesSiteSkinStructure of beta Cell of isletStudentsTechniquesTechnologyTrainingTransgenic MiceViralanalytical toolbasebrain researchcell typecomorbiditycostdesigndesigner receptors exclusively activated by designer drugsexome sequencingexperimental studyfeedinggenetic manipulationgenome editinginduced pluripotent stem cellinstrumentationinterestinvestigator trainingmembernew technologynext generation sequencingnovelnutritionoptogeneticsprogramsresearch and developmentskillsstem cell technologystem cellssuccesstooltranscriptome sequencing
项目摘要
MBMG Core
PROJECT SUMMARY/ABSTRACT
The Molecular Biology/Molecular Genetics (MBMG) Core has served the NYORC obesity research community
for the past 4 cycles of this grant. The MBMG Core provides critical research support for obesity-related clinical
and basic research activities in the area of molecular genetics, bioinformatics, and model organism
characterization. The services are widely used and have increased productivity of NORC investigators, while
curtailing costs and facilitating access to advanced genomics technologies.
The primary objective of this Core is to assist investigators to apply the tools and technologies of molecular
genetics and genomics to elucidate the molecular-genetic bases for the pathogenesis and
medical/physiological co-morbidities of obesity. The Specific Aims of the MBMG Core are: 1) To facilitate the
application of molecular genetics to problems of obesity by providing expert consultation on both study design
and applicable molecular biological techniques; 2) To provide standard laboratory services to young
investigators and those without formal labs for studies related to obesity; 3) To develop and make available
new cutting edge research tools and reagents. To these ends, the MBMG Core offers, among others,
consultation and services, including gene expression, DNA extraction, genotyping, DNA and RNA sequencing,
bacterial phylogenetic characterization by 16s rRNA, mouse transgenics, stem cell derivation and
differentiation, and genome editing with CRISPR Cas9, analytic tools related to these techniques. Core
services are of 3 basic types: (i) On-site Direct Services. (ii) Consultative-Collaborative with Institutional Cores.
(iii) Consultative-Referral. To gain access to cutting-edge technologies, avoid duplication and to maximally
leverage our resources, we collaborate extensively with other local Core facilities and laboratories. Core
personnel provide assistance ranging from study design to execution of studies and data interpretation. We
particularly emphasize service to young investigators and holders of P&F grants. The Core has been active in
developing new research tools and reagents, and has played an essential role in establishing iPS cell
technology for our community. Our R&D activities are focused on developing new tools and reagents for brain
research and genetic manipulations in cells and model animals. The MBMG Core has been a nexus for
intellectual exchange and collaboration, and an important training venue for students, fellows and young
faculty. During the past cycle, the Core responded to >3,000 service requests from 34 NORC users supported
by 49 grants, in addition to 11 non-ORC members. These services helped investigators generate 35 new
grants and 147 publications.
MBMG核心
项目总结/摘要
分子生物学/分子遗传学(MBMG)核心服务于NYORC肥胖研究社区
在过去的四个周期中,这一补助金。MBMG核心为肥胖相关的临床研究提供了关键的研究支持。
分子遗传学、生物信息学和模式生物领域的基础研究活动
特征化这些服务被广泛使用,提高了NORC调查人员的工作效率,
降低成本并促进获得先进的基因组学技术。
本核心的主要目标是帮助研究人员应用分子生物学的工具和技术,
遗传学和基因组学,以阐明发病机制的分子遗传基础,
肥胖的医学/生理共病。MBMG核心的具体目标是:1)促进
分子遗传学在肥胖问题上的应用,为两种研究设计提供专家咨询
及适用的分子生物学技术; 2)为青少年提供标准的实验室服务,
研究人员和那些没有正式实验室的人进行与肥胖有关的研究; 3)开发并提供
新的尖端研究工具和试剂。为此,MBMG核心提供,除其他外,
咨询和服务,包括基因表达,DNA提取,基因分型,DNA和RNA测序,
通过16 s rRNA、小鼠转基因、干细胞衍生和
分化和使用CRISPR Cas9的基因组编辑,与这些技术相关的分析工具。核心
服务有三种基本类型:(一)现场直接服务。(ii)与机构核心进行协商合作。
(iii)咨询转介。为了获得尖端技术,避免重复,
利用我们的资源,我们与其他当地核心设施和实验室进行广泛合作。核心
人员提供从研究设计到研究执行和数据解释的协助。我们
特别强调为年轻的研究人员和P&F赠款持有人提供服务。核心一直积极参与
开发新的研究工具和试剂,并在建立iPS细胞中发挥了重要作用
技术为我们的社区。我们的研发活动集中在开发新的工具和试剂,
细胞和模型动物的研究和遗传操作。MBMG核心一直是
知识交流与合作,是学生、研究员和青年的重要培训场所
教师。在上一个周期,核心服务中心对来自34个NORC用户的3,000多项服务请求作出了回应
除11名非ORC成员外,还有49名赠款。这些服务帮助调查人员产生了35个新的
赠款物147篇。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Wendy K Chung其他文献
Recent advances in understanding neurodevelopmental outcomes in congenital heart disease
先天性心脏病神经发育结局理解方面的最新进展
- DOI:
10.1016/j.gde.2022.101938 - 发表时间:
2022-08-01 - 期刊:
- 影响因子:3.600
- 作者:
Alban Ziegler;Wendy K Chung - 通讯作者:
Wendy K Chung
Wendy K Chung的其他文献
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{{ truncateString('Wendy K Chung', 18)}}的其他基金
Fair Phenotype Annotation and Genomic Reinterpretation
公平表型注释和基因组重新解释
- 批准号:
10675315 - 财政年份:2023
- 资助金额:
$ 22.94万 - 项目类别:
Prospective Genetic Risk Evaluation and Assessment (PROGRESS) in Autism
自闭症的前瞻性遗传风险评估(PROGRESS)
- 批准号:
10531728 - 财政年份:2022
- 资助金额:
$ 22.94万 - 项目类别:
Prospective Genetic Risk Evaluation and Assessment (PROGRESS) in Autism
自闭症的前瞻性遗传风险评估(PROGRESS)
- 批准号:
10698037 - 财政年份:2022
- 资助金额:
$ 22.94万 - 项目类别:
Project 1: Identifying and optimizing monogenetic risk prediction for autism in newborns
项目 1:识别和优化新生儿自闭症单基因风险预测
- 批准号:
10698081 - 财政年份:2022
- 资助金额:
$ 22.94万 - 项目类别:
Identifying and applying genetic variation relevant to clinical outcomes for individuals with congenital heart disease
识别和应用与先天性心脏病患者临床结果相关的遗传变异
- 批准号:
10028016 - 财政年份:2020
- 资助金额:
$ 22.94万 - 项目类别:
Role of the Kinesin KIF1A in Neurological Disease
驱动蛋白 KIF1A 在神经系统疾病中的作用
- 批准号:
10328907 - 财政年份:2020
- 资助金额:
$ 22.94万 - 项目类别:
Role of the Kinesin KIF1A in Neurological Disease
驱动蛋白 KIF1A 在神经系统疾病中的作用
- 批准号:
10543786 - 财政年份:2020
- 资助金额:
$ 22.94万 - 项目类别:
Identifying and applying genetic variation relevant to clinical outcomes for individuals with congenital heart disease
识别和应用与先天性心脏病患者临床结果相关的遗传变异
- 批准号:
10226278 - 财政年份:2020
- 资助金额:
$ 22.94万 - 项目类别:
Identifying and applying genetic variation relevant to clinical outcomes for individuals with congenital heart disease
识别和应用与先天性心脏病患者临床结果相关的遗传变异
- 批准号:
10460590 - 财政年份:2020
- 资助金额:
$ 22.94万 - 项目类别:
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