Integrative Technologies Support Core

综合技术支持核心

• 批准号: 9903301
• 负责人: YING XIA
• 金额: $ 26.63万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9903301
• 关键词: Acute; Advisory Committees; Animal Behavior; Applications Grants; Awareness; Budgets; Cells; Chronic; Clinical; Communities; Consultations; Core Facility; DNA Sequencing Facility; Data Analyses; Data Collection; Development; Educational workshop; Ensure; Environment; Environmental Health; Evaluation; Exposure to; Flow Cytometry; Funding; Genetic; Genetic Models; Genomics; Genotype; Health; Human; Human Resources; Individual; Inhalation; Institution; Knowledge; Longevity; Medical center; Mission; Modeling; Modernization; National Institute of Environmental Health Sciences; Output; Pediatric Hospitals; Performance; Phenotype; Pluripotent Stem Cells; Proteomics; Publications; Research; Research Personnel; Science; Services; Structure; System; Techniques; Technology; Time; Transgenic Animals; Translating; Translations; Universities; Vision; base; cohort; cost effectiveness; design; disability; disorder prevention; environmental agent; epigenomics; experimental study; flexibility; gene environment interaction; genome editing; health science research; human disease; improved; in vivo; innovation; instrumentation; meetings; member; metabolomics; method development; new technology; next generation sequencing; operation; population health; recruit; response; satisfaction; technological innovation

PROJECT SUMMARY The mission of the Center for Environmental Genetics (CEG) is to study gene-environment (GxE) interactions, in response to chronic and/or acute exposure(s) to environmental agents across human lifespan, and their ensuing impact on the development of human disease and disability, with the ultimate aim of improving individual and population health. To accomplish this mission, our research requires high-end, cutting-edge technologies in environmental health sciences (EHS). The purpose of the CEG Integrative Technologies Support (ITS) Core is to furnish CEG members with the latest technologies in a manner that enhances research output, increases cost effectiveness, and maximizes the impacts of Center research. The ITS uses a model of providing direct subsidies for members to use leading-edge technologies in existing core facilities. The Core is structured to have maximum flexibility to change and adapt to new needs in EHS research as well as further technological advances. The inclusion of existing facilities in the ITS Core is based on usage, quality of services, technological novelty/investigative power, and services, in line with the vision of the CEG to integrate fundamental, translational, and clinical EHS research for the improvement of human health through cleaner environments. Facilities can be added or removed based on the aforementioned criteria. Aim 1 is to make state-of-the art specialized services available and affordable to Center members through subsidies and expert consultation. The components of the ITS Core are comprised of selected established facilities. CEG members can request matching funds for the use of these services as well as for methods development. Aim 2 is to ensure high-quality innovative technological support for members through the annual evaluation of usage, customer satisfaction of service, and the “right” composition of the ITS Core. The demand for a specific facility service changes based on the needs of the investigators or the exceptionality of the new technology. To remain nimble and up to date, components of the ITS Core will be evaluated annually by an evaluation committee. Aim 3 is to promote awareness of new technologies among current CEG investigators and assist in the recruitment of new members to the Center. The ITS Core will sponsor workshops and seminars on the technologies/services and educate and inform users on how these modern technologies can enhance research. The ITS Core is designed to be a nimble, fast, and fair system of subsidized usage of the latest technologies. It also seeks to encourage established facilities to develop new technologies meeting the needs of CEG members. The currently provided services include next-generation sequencing for research in genomics and epigenomics, proteomics, genotyping, in vivo genome editing, and flow cytometry. New technologies in development include single-cell genomics, and mitochondriomics. The ITS Core stimulates integration by bringing together our experts to develop transdisciplinary crosstalk, make connections, build a network of experts, and increase the quality of EHS research locally and around the world.

项目总结 环境遗传学中心(CEG)的任务是研究基因与环境(GxE)的相互作用， 为了应对人类一生中长期和/或急性暴露于环境制剂(S)，以及他们 对人类疾病和残疾的发展产生影响，最终目的是改善个人 和人口健康。为了完成这一使命，我们的研究需要高端、尖端的技术在 环境健康科学(EHS)。CEG综合技术支持(ITS)核心的目的是 向CEG成员提供最新技术，以提高研究产出，增加成本 有效性，并最大限度地发挥中心研究的影响。智能交通运输系统采用直接补贴的模式 让成员在现有的核心设施中使用尖端技术。核心的结构是具有最大 灵活地改变和适应EHS研究的新需求以及进一步的技术进步。这个 将现有设施纳入智能交通运输系统核心取决于使用情况、服务质量、技术 新颖性/调查力和服务，符合CEG的愿景，将基础、 为通过更清洁的环境改善人类健康而进行的翻译、临床EHS研究。 可根据上述标准添加或删除设施。目标1是让最先进的 通过补贴和专家咨询，为中心成员提供和负担得起的专业服务。这个 智能交通运输系统核心的组成部分由选定的现有设施组成。CEG成员可以申请 用于使用这些服务以及方法开发的配套资金。目标二是确保高质量 通过年度使用情况评估、客户满意度评估为会员提供创新的技术支持 服务，以及ITS核心的“正确”组成。对特定设施服务的需求基于以下方面发生变化 根据调查人员的需要或新技术的例外情况。为了保持灵活和与时俱进， 智能交通运输系统核心的组成部分将由一个评价委员会每年进行评价。目标3是促进 提高现有CEG调查员对新技术的认识，并协助招募新成员 去中心。ITS核心将主办关于技术/服务和教育的讲习班和研讨会 并向用户介绍这些现代技术如何加强研究。ITS核心被设计为一种 灵活、快速、公平的最新技术补贴使用制度。它还试图鼓励 建立设施以开发满足CEG成员需求的新技术。当前提供的 服务包括用于基因组学和表观基因组学、蛋白质组学、 基因分型、体内基因组编辑和流式细胞术。正在开发的新技术包括单细胞 基因组学和线粒体学。ITS核心通过将我们的专家聚集在一起来促进集成 发展跨学科相声，建立联系，构建专家网络，提高 EHS在本地和世界各地的研究。