Integrative Technologies Support Core

综合技术支持核心

• 批准号: 9903301
• 负责人: YING XIA
• 金额: $ 26.63万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9903301
• 关键词: Acute; Advisory Committees; Animal Behavior; Applications Grants; Awareness; Budgets; Cells; Chronic; Clinical; Communities; Consultations; Core Facility; DNA Sequencing Facility; Data Analyses; Data Collection; Development; Educational workshop; Ensure; Environment; Environmental Health; Evaluation; Exposure to; Flow Cytometry; Funding; Genetic; Genetic Models; Genomics; Genotype; Health; Human; Human Resources; Individual; Inhalation; Institution; Knowledge; Longevity; Medical center; Mission; Modeling; Modernization; National Institute of Environmental Health Sciences; Output; Pediatric Hospitals; Performance; Phenotype; Pluripotent Stem Cells; Proteomics; Publications; Research; Research Personnel; Science; Services; Structure; System; Techniques; Technology; Time; Transgenic Animals; Translating; Translations; Universities; Vision; base; cohort; cost effectiveness; design; disability; disorder prevention; environmental agent; epigenomics; experimental study; flexibility; gene environment interaction; genome editing; health science research; human disease; improved; in vivo; innovation; instrumentation; meetings; member; metabolomics; method development; new technology; next generation sequencing; operation; population health; recruit; response; satisfaction; technological innovation

PROJECT SUMMARY The mission of the Center for Environmental Genetics (CEG) is to study gene-environment (GxE) interactions, in response to chronic and/or acute exposure(s) to environmental agents across human lifespan, and their ensuing impact on the development of human disease and disability, with the ultimate aim of improving individual and population health. To accomplish this mission, our research requires high-end, cutting-edge technologies in environmental health sciences (EHS). The purpose of the CEG Integrative Technologies Support (ITS) Core is to furnish CEG members with the latest technologies in a manner that enhances research output, increases cost effectiveness, and maximizes the impacts of Center research. The ITS uses a model of providing direct subsidies for members to use leading-edge technologies in existing core facilities. The Core is structured to have maximum flexibility to change and adapt to new needs in EHS research as well as further technological advances. The inclusion of existing facilities in the ITS Core is based on usage, quality of services, technological novelty/investigative power, and services, in line with the vision of the CEG to integrate fundamental, translational, and clinical EHS research for the improvement of human health through cleaner environments. Facilities can be added or removed based on the aforementioned criteria. Aim 1 is to make state-of-the art specialized services available and affordable to Center members through subsidies and expert consultation. The components of the ITS Core are comprised of selected established facilities. CEG members can request matching funds for the use of these services as well as for methods development. Aim 2 is to ensure high-quality innovative technological support for members through the annual evaluation of usage, customer satisfaction of service, and the “right” composition of the ITS Core. The demand for a specific facility service changes based on the needs of the investigators or the exceptionality of the new technology. To remain nimble and up to date, components of the ITS Core will be evaluated annually by an evaluation committee. Aim 3 is to promote awareness of new technologies among current CEG investigators and assist in the recruitment of new members to the Center. The ITS Core will sponsor workshops and seminars on the technologies/services and educate and inform users on how these modern technologies can enhance research. The ITS Core is designed to be a nimble, fast, and fair system of subsidized usage of the latest technologies. It also seeks to encourage established facilities to develop new technologies meeting the needs of CEG members. The currently provided services include next-generation sequencing for research in genomics and epigenomics, proteomics, genotyping, in vivo genome editing, and flow cytometry. New technologies in development include single-cell genomics, and mitochondriomics. The ITS Core stimulates integration by bringing together our experts to develop transdisciplinary crosstalk, make connections, build a network of experts, and increase the quality of EHS research locally and around the world.

项目概要 环境遗传学中心（CEG）的使命是研究基因与环境（GxE）的相互作用， 应对人类一生中长期和/或急性接触环境因素的情况，及其 从而对人类疾病和残疾的发展产生影响，最终目的是改善个人 和人口健康。为了完成这一使命，我们的研究需要高端、尖端技术 环境健康科学（EHS）。 CEG 综合技术支持 (ITS) 核心的目的是 以提高研究成果、增加成本的方式向 CEG 成员提供最新技术 有效性，并最大限度地发挥中心研究的影响。 ITS采用提供直接补贴的模式 使成员能够在现有核心设施中使用领先技术。核心的结构具有最大 灵活地改变和适应 EHS 研究的新需求以及进一步的技术进步。这 将现有设施纳入 ITS 核心取决于使用情况、服务质量、技术 新颖性/调查能力和服务，符合 CEG 整合基础、 通过更清洁的环境改善人类健康的转化和临床 EHS 研究。 可以根据上述标准添加或删除设施。目标1是打造最先进的 通过补贴和专家咨询，中心成员可以获得且负担得起的专业服务。这 ITS 核心的组成部分由选定的已建设施组成。 CEG 会员可以请求 为使用这些服务以及方法开发提供配套资金。目标2：确保高质量 通过年度使用情况评估、客户满意度评估为会员提供创新技术支持 服务，以及 ITS 核心的“正确”组成。对特定设施服务的需求发生变化 根据研究人员的需要或新技术的特殊性。为了保持敏捷性并与时俱进， ITS 核心的组成部分将由评估委员会每年进行评估。目标3是促进 当前 CEG 调查员对新技术的认识并协助招募新成员 到中心。 ITS 核心将主办有关技术/服务的讲习班和研讨会，并进行教育 并告知用户这些现代技术如何加强研究。 ITS 核心被设计为 灵活、快速、公平的最新技术使用补贴制度。它还旨在鼓励 建立设施来开发满足 CEG 成员需求的新技术。目前提供的 服务包括用于基因组学和表观基因组学、蛋白质组学研究的下一代测序， 基因分型、体内基因组编辑和流式细胞术。正在开发的新技术包括单细胞 基因组学和线粒体组学。 ITS 核心通过汇集我们的专家来促进整合 发展跨学科交叉对话、建立联系、建立专家网络并提高研究质量 本地和世界各地的 EHS 研究。