Role of hemeoxygenase-1 in experimental acute pancreatitis
hemeoxygenase-1 在实验性急性胰腺炎中的作用
基本信息
- 批准号:9903274
- 负责人:
- 金额:$ 44.19万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-09-20 至 2022-03-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteAcute DiseaseAdoptive TransferAlcoholsAnimalsBiliaryBiliverdineBloodCalculiCarbon MonoxideCell CommunicationCell TherapyCellsCharacteristicsClinicalClinical TrialsCoupledCytometryDNADataDevelopmentDiseaseDisease OutcomeDisease ProgressionDistantEndoscopic Retrograde CholangiopancreatographyEnrollmentEuropeExcisionExperimental ModelsFrequenciesHeminHemoglobinHeterogeneityHospitalizationHumanImmuneImmune responseInflammationInflammatoryInflammatory ResponseInterleukin-10LeadLeukocytesLungMacrophage ActivationMediatingModelingMorbidity - disease rateNatureOrganPancreasPancreatitisPathogenesisPathogenicityPathway interactionsPatientsPhasePhenotypePilot ProjectsPrecipitating FactorsPreventionProgressive DiseaseProsthesisReceptor Up-RegulationRecoveryResearchResolutionRoleSignal TransductionSpleenStimulator of Interferon GenesSystemT-Cell ActivationT-LymphocyteTLR4 geneTNF geneTechniquesTestingTherapeuticTimeTranslatingTumor-infiltrating immune cellsVirus Diseasesacute pancreatitisbaseburden of illnesscell injurychronic pancreatitisclinical practiceclinically significantcytokinegastrointestinalheme oxygenase-1immune activationimprovedinterleukin-22macrophagemonocytemortalitynovelnovel therapeuticsprotective effectrecruitstellate cell
项目摘要
Acute pancreatitis (AP) remains a challenging clinical problem, particularly in patients with severe
disease. Despite its disease burden, therapy remains supportive at best coupled with removal of
precipitating factors that may include alcohol or biliary obstructing calculi. We showed a protective effect
and therapeutic role of hemin (hemoglobin prosthetic moiety that upregulates hemeoxygenase-1, HO-1)
in experimental AP via recruitment of HO-1+ F4/80+ cells to the pancreas. Moreover, we also elucidated
mechanism for beneficial effects of HO-1 downstream effectors. Given these results, we propose to test
the hypothesis that there is shift in immune response during recovery from AP as compare to acute
phases of AP and we propose here to understand these mechanisms in order to improve our
understanding of immune pathways that promote recovery and resolution of the inflammation. The
specific aims of our proposal are: Aim 1: Phenotypic and functional assessment. Here we will test the
hypothesis that resolution of AP is associated with an increased adaptive and decreased
monocyte/macrophage recruitment as compared to acute phase of AP. Aim 2: Cellular cross talk in the
pathogenesis of acute pancreatitis. Here we will test the hypothesis that activated pancreatic stellate
cells secrete factors that alter pro-inflammatory macrophages recruited during acute phase of AP into
suppressive macrophages that promote recovery. Aim 3: Innate immune activation and cell damage
associated signals in pancreatitis. Here we will test the hypothesis that unlike macrophages in acute
phase of AP, macrophages during recovery mediate recovery by suppressing T cell activation and
proliferation. During severe or acute phase of AP however, macrophages sense cellular damage
components and activate pathways that perpetuate pro-inflammatory cytokine release. Findings from this
project will allow for a better understanding of immune responses and infiltrates associated with acute
phases of AP and recovery. In addition to the gained understanding of immune mechanisms that
mediate and/or allow progression of AP and recovery, the potential impact of this project is of great
clinical significance, as our studies may lead to the development of novel therapies that can alter clinical
practice in a disease for which no active therapy is available.
急性胰腺炎(AP)仍然是一个具有挑战性的临床问题,特别是在严重的胰腺炎患者中
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Aida Habtezion其他文献
Aida Habtezion的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Aida Habtezion', 18)}}的其他基金
A Clinical Center to Study Immunological and Hormonal Biomarkers for the Diagnosis, Prediction and Treatment of Chronic Pancreatitis and its associated development to Diabetes and Pancreas Cancer
研究用于诊断、预测和治疗慢性胰腺炎及其与糖尿病和胰腺癌相关发展的免疫和激素生物标志物的临床中心
- 批准号:
10252512 - 财政年份:2020
- 资助金额:
$ 44.19万 - 项目类别:
Role and Regulation of colon Trafficking Novel G-Protein Coupled Receptors
结肠贩运新型 G 蛋白偶联受体的作用和调节
- 批准号:
9193634 - 财政年份:2016
- 资助金额:
$ 44.19万 - 项目类别:
Role and Regulation of colon Trafficking Novel G-Protein Coupled Receptors
结肠贩运新型 G 蛋白偶联受体的作用和调节
- 批准号:
9053003 - 财政年份:2016
- 资助金额:
$ 44.19万 - 项目类别:
A Clinical Center to Study Immunological and Hormonal Biomarkers for the Diagnosis, Prediction and Treatment of Chronic Pancreatitis and its associated development to Diabetes and Pancreas Cancer
研究用于诊断、预测和治疗慢性胰腺炎及其与糖尿病和胰腺癌相关发展的免疫和激素生物标志物的临床中心
- 批准号:
9352334 - 财政年份:2015
- 资助金额:
$ 44.19万 - 项目类别:
A Clinical Center to Study Immunological and Hormonal Biomarkers for the Diagnosis, Prediction and Treatment of Chronic Pancreatitis and its associated development to Diabetes and Pancreas Cancer
研究用于诊断、预测和治疗慢性胰腺炎及其与糖尿病和胰腺癌相关发展的免疫和激素生物标志物的临床中心
- 批准号:
9150617 - 财政年份:2015
- 资助金额:
$ 44.19万 - 项目类别:
Enteric Neural Stem Cell Loss with Aging: Role of Immune Cells and Inflammation
肠道神经干细胞随衰老而丧失:免疫细胞和炎症的作用
- 批准号:
8842824 - 财政年份:2015
- 资助金额:
$ 44.19万 - 项目类别:
Enhancing Enrollment for NOD and DETECT studies of the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer
增加慢性胰腺炎、糖尿病和胰腺癌研究联盟 NOD 和 DETECT 研究的招募
- 批准号:
9983467 - 财政年份:2015
- 资助金额:
$ 44.19万 - 项目类别:
Role of hemeoxygenase-1 in experimental acute pancreatitis
hemeoxygenase-1 在实验性急性胰腺炎中的作用
- 批准号:
8246213 - 财政年份:2011
- 资助金额:
$ 44.19万 - 项目类别:
Role of hemeoxygenase-1 in experimental acute pancreatitis
hemeoxygenase-1 在实验性急性胰腺炎中的作用
- 批准号:
8689006 - 财政年份:2011
- 资助金额:
$ 44.19万 - 项目类别:
相似海外基金
Improving Acute Disease Management for Patients with Alzheimer's Disease and Related Dementias
改善阿尔茨海默病和相关痴呆症患者的急性疾病管理
- 批准号:
10712647 - 财政年份:2001
- 资助金额:
$ 44.19万 - 项目类别:
INDUCTION OF ACUTE DISEASE IN MACAQUES BY NEF GENE VARIANT OF SIVMAC239
SIVMAC239 的 NEF 基因变体在猕猴中诱导急性疾病
- 批准号:
6247642 - 财政年份:1997
- 资助金额:
$ 44.19万 - 项目类别:
INDUCTION OF ACUTE DISEASE IN MACAQUES BY NEF GENE VARIANT OF SIVMAC239
SIVMAC239 的 NEF 基因变体在猕猴中诱导急性疾病
- 批准号:
3718999 - 财政年份:
- 资助金额:
$ 44.19万 - 项目类别:
Neurophysiological alterations in multiple sclerosis patients during acute disease acivity
多发性硬化症患者急性疾病活动期间的神经生理学变化
- 批准号:
465668867 - 财政年份:
- 资助金额:
$ 44.19万 - 项目类别:
Research Grants
SIVMAC 1NEF ALLELE: LYMPHOCYTE ACTIVATION & ACUTE DISEASE IN MACAQUE MONKEYS
SIVMAC 1NEF 等位基因:淋巴细胞激活
- 批准号:
3719026 - 财政年份:
- 资助金额:
$ 44.19万 - 项目类别: