Project 2 - Environmental Project 2 - EP2 - Toxic Metals in Airborne Particulate Matter Originating from Abandoned Uranium Mine (AUM) Sites

项目 2 - 环境项目 2 - EP2 - 源自废弃铀矿 (AUM) 场地的空气颗粒物中的有毒金属

• 批准号: 9903353
• 负责人: Adrian J Brearley
• 金额: $ 21.39万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9903353
• 关键词: Address; Air; Airborne Particulate Matter; Arizona; Arsenic; Autoimmune Diseases; Biological Availability; Biological Monitoring; Birth; Caliber; Cardiovascular Diseases; Characteristics; Chemicals; Coal; Cohort Studies; Collection; Communities; Complex; Copper; Data; Data Set; Disease; Electron Microscopy; Environmental Health; Environmental Pollution; Environmental Wind; Exhibits; Exposure to; Grain; Health; Hot Spot; Hypertension; Image; Immune System Diseases; Individual; Infant; Inflammatory; Inhalation; Inhalation Exposure; Intake; Laboratories; Longevity; Lung; Malignant Neoplasms; Measurement; Metal exposure; Metals; Meteorology; Mining; Modeling; Monitor; Morphology; National Health and Nutrition Examination Survey; Native Americans; Navajo; New Mexico; Nickel; Oils; Oral; Parents; Particle Size; Particulate; Particulate Matter; Process; Property; Public Health; Pueblo Race; Research; Residual state; Risk; Risk Estimate; Risk Reduction; Role; Site; Soil; Solubility; Source; Superfund; Surface; System; Tail; Techniques; Testing; Toxic effect; Transition Elements; Uncertainty; Uranium; Urine; Vanadium; Vulnerable Populations; War; Water; X ray spectroscopy; absorption; atmospheric modeling; base; climate change; community living; density; experience; exposure pathway; ground water; hazard; member; nanoparticle; oxidation; performance site; programs; receptor; remediation; restoration; toxic metal; tribal community; tribal lands; wasting

PROJECT 2 - ENVIRONMENTAL PROJECT 2 – EP2 - PROJECT SUMMARY Abandoned uranium mines (AUM) situated on the tribal lands of the Navajo Nation and Laguna pueblo represent a major source of environmental contamination that threatens public health as a result of mobilization of toxic metals mixtures bearing uranium (U), vanadium (V), copper (Cu), arsenic (As). The transport of toxic metals mixtures into the air, and the potential for inhalational exposures, has never been investigated in a rigorous manner. The proposed research will investigate the potential exposure hazards to toxic metals mixtures resulting from inhalation of particulate matter (PM) derived from three different AUM sites located on Navajo Nation on Laguna Pueblo tribal lands in New Mexico and Arizona. The project will address the two specific aims: 1) Defining the physical, chemical and mineralogic profile of metals mixtures in AUM- impacted soils and assessing vulnerability to transport by wind; and 2) Developing a process model for the resuspension and transport of metal-bearing PM from AUM sites to estimate exposure risks for nearby vulnerable communities. For the process model, we will a) ascertain the particle size distributions and mineralogic characteristics of metal-bearing PM originating from AUM sites and the exposure potential to vulnerable populations living in the regional airshed under varied meteorological conditions; and b) conduct source-receptor modeling for the region, integrating information from three performance sites and deriving long-term estimates for Navajo community members. The proposed research will utilize state-of-the-art monitoring, chemical, imaging and atmospheric modeling techniques to provide a comprehensive dataset on the concentrations, speciation, valence, solubility, etc., of metals in different size fractions down to the nanoparticle scale that are essential to evaluate the potential toxicity and inhalation exposure risk for PM. The results will reduce uncertainty regarding the metal content, exposure concentrations, and sources of AUM- related PM exposures in risk reduction strategies.

项目 2 - 环境项目 2 - EP2 - 项目摘要 位于纳瓦霍族和拉古纳普韦布洛部落土地上的废弃铀矿 (AUM) 是威胁公众健康的环境污染的主要来源 含有铀 (U)、钒 (V)、铜 (Cu)、砷 (As) 的有毒金属混合物的流动。这 有毒金属混合物向空气中的输送以及吸入暴露的可能性从未得到解决 严肃查处。拟议的研究将调查潜在的暴露危害 吸入来自三个不同 AUM 站点的颗粒物 (PM) 产生的有毒金属混合物 位于新墨西哥州和亚利桑那州拉古纳普韦布洛部落土地上的纳瓦霍族保留地。该项目将解决 两个具体目标： 1) 定义 AUM 中金属混合物的物理、化学和矿物学特征 受影响的土壤并评估风运输的脆弱性； 2) 开发一个流程模型 从 AUM 站点重新悬浮和运输含金属颗粒物，以估计附近的暴露风险 弱势社区。对于过程模型，我们将 a) 确定颗粒尺寸分布和 源自 AUM 站点的含金属 PM 的矿物学特征以及暴露于 生活在不同气象条件下的区域空气流域的弱势群体； b) 进行 该区域的源-受体建模，整合来自三个性能站点的信息并得出 对纳瓦霍社区成员的长期估计。拟议的研究将利用最先进的技术 监测、化学、成像和大气建模技术，提供全面的数据集 不同尺寸分数的金属的浓度、形态、化合价、溶解度等 纳米颗粒尺度对于评估 PM 的潜在毒性和吸入暴露风险至关重要。这 结果将减少有关金属含量、暴露浓度和 AUM 来源的不确定性 风险降低策略中的相关颗粒物暴露。