Exposure Science Core

暴露科学核心

• 批准号: 9903362
• 负责人: Justin Gary Teeguarden
• 金额: $ 26.76万
• 依托单位: TEXAS A&M UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9903362
• 关键词: Address; Area; Aromatic Polycyclic Hydrocarbons; Biological; Biological Monitoring; Cells; Chemical Exposure; Chemical Structure; Chemicals; Collaborations; Communication Research; Communities; Community Outreach; Complex; Complex Mixtures; Custom; Data; Decision Making; Development; Dioxins; Disasters; Disease; Drug Kinetics; Effectiveness; Emergency Situation; Ensure; Environment; Environmental Exposure; Environmental Health; Environmental Monitoring; Environmental Pollution; Evaluation; Event; Exposure to; Furans; Gas-Liquid Chromatography; Genetic; Goals; Hazard Identification; Health; Health protection; Human; In Vitro; Individual; Ions; Isotopes; Laboratories; Libraries; Mass Spectrum Analysis; Measurement; Measures; Metals; Methods; Modeling; Natural Disasters; Nature; Outcome; Pacific Northwest; Pesticides; Phase; Polychlorinated Biphenyls; Public Health; Research; Resolution; Sampling; Science; Scientist; Ships; Solid; Solvents; Speed; Structure; Superfund; System; Technology; Testing; Texas; Toxic effect; Toxicity Tests; Toxicology; Translating; Translational Research; Translations; United States National Academy of Sciences; Universities; Work; base; exposed human population; hazard; health goals; human genome sequencing; in vivo; instrument; interest; ion mobility; mass spectrometer; novel; programs; rapid detection; response; tool; toxicant; volatile organic compound

Exposure Science Core ABSTRACT The objective of the Texas A&M Superfund Research Center is to explore and develop descriptive models and tools that can predict the possible hazardous outcomes of chemical exposure during environmental emergencies and to produce powerful solutions which can mitigate the negative effects on human health. The ultimate goal of the Center is to contribute to decision-making capabilities for planning and control in emergency environmental contamination events. Exposure science is evolving rapidly in parallel with novel methods for hazard identification with a focus on solving the challenges of rapid detection of potentially harmful chemicals at low but biologically relevant concentrations. The overall goal of the Exposure Science Core is to address the needs of the Texas A&M University (TAMU) Superfund Research Center for novel analytical approaches in both exposure science and hazard identification under conditions of an environmental emergency contamination event. The Core is a partnership between Drs. Justin Teeguarden and Erin Baker at Pacific Northwest National Laboratory and Dr. Terry Wade at Texas A&M University. The Core will address this objective and enable exposure characterization of complex environmental exposures and mixtures by coordinating exposure science activities across the Center and (i) developing novel sample processing and analysis methods, (ii) translating these advances into practice for environmental health protection, and (iii) providing essential analytical support to the projects in the Center and beyond. The Exposure Science Core will coordinate exposure assessments across the Center by working very closely with Project 1 to characterize the real-world mixtures that will be used in other Projects and Cores, as well as it will ensure consistency and relevance of these estimates for use in toxicity testing (Projects 3 and 4), decision making (Decision Science Core), and effectiveness of hazard reduction (Project 2) and communication (Research Translation Core, Community Engagement Core). A suite of sensitive quantitative targeted analyses will be used to identify and quantify target contaminants of human health concern in the Galveston Bay/Houston Ship Channel. Building on these conventional analyses, global non-targeted analysis of samples using a RapidFire™ Solid Phase Extraction-Ion Mobility-Mass Spectrometry (SPE-IMS-MS) will be used to characterize previously unknown chemical exposures and environmentally relevant mixtures for toxicity testing. A novel computational chemical structure and identification pipeline developed by our team will be used to make new libraries and make provisional chemical identifications. These transformative scientific aims will advance the goals of all four projects and the overall Center goal of developing rapid, effective tools for disaster response related to human exposures.

《曝光科学》核心摘要 德州农工超级基金研究中心的目标是探索和开发描述性模型和 可预测环境中化学物质暴露可能产生的危险后果的工具 紧急情况，并制定强有力的解决办法，以减轻对人类健康的负面影响。这个 该中心的最终目标是为紧急情况下的规划和控制提供决策能力 环境污染事件。曝光科学正在快速发展，同时也有新的方法 危险识别，重点是解决快速检测潜在有害化学物质的挑战 低但与生物相关的浓度。曝光科学核心的总体目标是解决 德克萨斯农工大学(TAMU)超级基金研究中心对两种新的分析方法的需求 环境突发污染条件下的暴露科学与危害识别 事件。The Core是太平洋西北国家医院的贾斯汀·蒂格登博士和埃琳·贝克博士的合作伙伴关系 实验室和德克萨斯农工大学的特里·韦德博士。核心将解决这一目标，并实现 通过协调暴露科学对复杂环境暴露和混合物的暴露表征 整个中心的活动和(1)开发新的样品处理和分析方法，(2)翻译 将这些进展转化为环境健康保护的实践，以及(3)为以下方面提供必要的分析支持 中心内和中心外的项目。暴露科学核心将协调以下方面的暴露评估 该中心通过与项目1密切合作，确定将用于其他项目的真实世界混合物的特征 项目和核心，并将确保用于毒性的这些估计数的一致性和相关性 测试(项目3和4)、决策(决策科学核心)和减少灾害的有效性 (项目2)和传播(研究翻译核心、社区参与核心)。一套敏感的 将使用定量目标分析来确定和量化人类健康问题的目标污染物 在加尔维斯顿海湾/休斯顿航道。在这些常规分析的基础上，全球非目标 ™固相萃取-离子迁移率-质谱法分析样品 将用于表征以前未知的化学暴露和与环境相关的混合物 毒性测试。我们团队开发的一种新型计算化学结构和鉴定流水线将是 用来建立新的图书馆和进行临时的化学鉴定。这些变革性的科学目标 将推进所有四个项目的目标和中心开发快速、有效工具的总体目标 与人类暴露有关的灾难应对。