Exposure Science Core

曝光科学核心摘要 德克萨斯A & M超级基金研究中心的目标是探索和开发描述性模型， 可以预测环境期间化学品暴露可能产生的危险后果的工具 我们的目标是，在紧急情况下采取有效措施，并制定有力的解决办法，减轻对人类健康的负面影响。的 该中心的最终目标是提高应急计划和控制的决策能力 环境污染事件。暴露科学正在迅速发展，与此同时， 危险识别，重点是解决快速检测潜在有害化学品的挑战， 低但具有生物学意义的浓度。暴露科学核心的总体目标是解决 德克萨斯A & M大学（TAMU）超级基金研究中心对两种新分析方法的需求 环境紧急污染条件下的暴露科学和危害识别 活动核心是贾斯汀Teeguarden博士和艾琳贝克在太平洋西北国家之间的伙伴关系 实验室和得克萨斯A & M大学的特里·韦德博士。核心小组将实现这一目标， 通过协调暴露科学确定复杂环境暴露和混合物的暴露特性 （一）开发新的样品处理和分析方法，（二）翻译 这些进展用于环境健康保护的实践，以及（iii）提供必要的分析支持， 中心及周边的项目。暴露科学核心将协调暴露评估， 该中心通过与项目1密切合作，对将用于其他项目的真实混合物进行表征， 项目和核心，以及它将确保这些估计的一致性和相关性，用于毒性 测试（项目3和4）、决策（决策科学核心）和减少危害的有效性 （项目2）和沟通（研究翻译核心，社区参与核心）。一套敏感的 定量目标分析将用于确定和量化人类健康关注的目标污染物 在加尔维斯顿湾/休斯顿航道。在这些常规分析的基础上， 使用RapidFire ™固相萃取-离子迁移率-质谱（SPE-IMS-MS）分析样品 将被用来描述以前未知的化学品接触和与环境有关的混合物， 毒性测试我们团队开发的一种新型计算化学结构和识别管道将在 用于建立新的文库和进行临时化学鉴定。这些变革性的科学目标 将推进所有四个项目的目标和中心的总体目标，即开发快速、有效的工具， 与人类接触有关的灾害应对。

Exposure Science Core ABSTRACT The objective of the Texas A&M Superfund Research Center is to explore and develop descriptive models and tools that can predict the possible hazardous outcomes of chemical exposure during environmental emergencies and to produce powerful solutions which can mitigate the negative effects on human health. The ultimate goal of the Center is to contribute to decision-making capabilities for planning and control in emergency environmental contamination events. Exposure science is evolving rapidly in parallel with novel methods for hazard identification with a focus on solving the challenges of rapid detection of potentially harmful chemicals at low but biologically relevant concentrations. The overall goal of the Exposure Science Core is to address the needs of the Texas A&M University (TAMU) Superfund Research Center for novel analytical approaches in both exposure science and hazard identification under conditions of an environmental emergency contamination event. The Core is a partnership between Drs. Justin Teeguarden and Erin Baker at Pacific Northwest National Laboratory and Dr. Terry Wade at Texas A&M University. The Core will address this objective and enable exposure characterization of complex environmental exposures and mixtures by coordinating exposure science activities across the Center and (i) developing novel sample processing and analysis methods, (ii) translating these advances into practice for environmental health protection, and (iii) providing essential analytical support to the projects in the Center and beyond. The Exposure Science Core will coordinate exposure assessments across the Center by working very closely with Project 1 to characterize the real-world mixtures that will be used in other Projects and Cores, as well as it will ensure consistency and relevance of these estimates for use in toxicity testing (Projects 3 and 4), decision making (Decision Science Core), and effectiveness of hazard reduction (Project 2) and communication (Research Translation Core, Community Engagement Core). A suite of sensitive quantitative targeted analyses will be used to identify and quantify target contaminants of human health concern in the Galveston Bay/Houston Ship Channel. Building on these conventional analyses, global non-targeted analysis of samples using a RapidFire™ Solid Phase Extraction-Ion Mobility-Mass Spectrometry (SPE-IMS-MS) will be used to characterize previously unknown chemical exposures and environmentally relevant mixtures for toxicity testing. A novel computational chemical structure and identification pipeline developed by our team will be used to make new libraries and make provisional chemical identifications. These transformative scientific aims will advance the goals of all four projects and the overall Center goal of developing rapid, effective tools for disaster response related to human exposures.