Superfund Training Core

超级基金培训核心

• 批准号: 9904690
• 负责人: David W Hein
• 金额: $ 7.14万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9904690
• 关键词: Address; Advisory Committees; Area; Arts; Biology; Chemical Exposure; Chemicals; Chemistry; Communication Research; Communities; County; Dentistry; Discipline of Nursing; Disease; Distal; Engineering; Environmental Exposure; Exposure to; Hazardous Substances; Health; High School Student; Human; Individual; Industrialization; Insulin Resistance; Interdisciplinary Study; Investigation; Laboratories; Measures; Medical Students; Medicine; Methods; Obesity; Outcome; Postdoctoral Fellow; Public Health; Research; Research Project Grants; Role; Schools; Science; Students; Superfund; System; Training; Training Programs; Translating; Translational Research; United States National Institutes of Health; Universities; base; cardiometabolism; college; environmental chemical; experience; high risk; human disease; lecturer; meetings; pre-doctoral; teacher; training project; undergraduate student; volatile organic compound

Abstract: Interdisciplinary research remains an important feature of the NIH Roadmap. An integrated investigation of chemicals in Louisville will address the effects of exposure on health outcomes related to cardiometabolic disease. The central hypothesis of the UofL Superfund Hazardous Substance Research and Training Project is that exposure to the environmental chemicals, volatile organic compounds (VOCs) causes/exacerbates insulin resistance, leading to cardio-metabolic disease. Preliminary results from our biomedical projects provide evidence that obesity places individuals at higher risk to adverse health outcomes related to VOCs exposures, while our non-biomedical projects will address the lack of methods to systematically measure exposure to these chemicals in residents distal and proximal to industrial areas. This Training Core will train our pre- and post-doctoral fellows not only in laboratory-based research, but also in effective communication of the research findings to others in the Superfund Research Projects, as well as to the Community at large. The Training Core will develop graduate courses for our Trainees to be shared with the UofL Schools of Engineering, Dentistry, Medicine and Nursing and the College of Arts & Sciences, providing the latest information about the chemistry and human health effects of volatile organic compounds. The Training Core also will contribute to the professional and undergraduate training programs by providing our trainees as seminar speakers or lecturers to UofL undergraduate Biology & Chemistry honors students, to nursing, dentistry, and medical students, and to teachers and high school students in the Jefferson County School System to communicate the role of chemical exposure in human disease. Finally, our trainees will participate in meetings with the West Louisville Task Force and the Metro Louisville Public Health and Wellness Department with our Community Engagement and Research Translation Cores to engage in discussion and answer questions about the Superfund research projects. Each trainee will be assigned a specific project that each trainee will develop in order to experience how to translate research findings into concepts that can be transmitted effectively to the community, various local/state agencies, and university audiences alike.

翻译后摘要：跨学科研究仍然是NIH路线图的一个重要特征。路易斯维尔的化学品综合调查将解决暴露对与心脏代谢疾病有关的健康结果的影响。UofL超级基金有害物质研究和培训项目的中心假设是，暴露于环境化学品，挥发性有机化合物（VOC）导致/加剧胰岛素抵抗，导致心脏代谢疾病。我们的生物医学项目的初步结果提供了证据，表明肥胖使个人面临与VOCs暴露相关的不良健康后果的风险更高，而我们的非生物医学项目将解决缺乏方法来系统地测量工业区远端和近端居民对这些化学品的暴露。该培训核心将培训我们的博士前和博士后研究员，不仅在实验室为基础的研究，而且在研究成果的有效沟通，以他人在超级基金研究项目，以及整个社会。培训核心将为我们的学员开发研究生课程，与UofL工程，牙科，医学和护理学院以及艺术与科学学院共享，提供有关挥发性有机化合物的化学和人类健康影响的最新信息。培训核心也将有助于专业和本科培训计划，通过提供我们的学员作为研讨会演讲者或讲师UofL本科生物学和化学荣誉学生，护理，牙科和医学生，以及教师和高中学生在杰斐逊县学校系统沟通化学暴露在人类疾病中的作用。最后，我们的学员将参加与西路易斯维尔工作队和路易斯维尔公共卫生和健康部门与我们的社区参与和研究翻译核心的会议，参与讨论和回答有关超级基金研究项目的问题。每个学员将被分配一个特定的项目，每个学员将开发该项目，以体验如何将研究成果转化为可以有效传播给社区、各个地方/州机构和大学受众的概念。