Superfund Training Core

摘要：跨学科研究仍然是NIH路线图的一个重要特征。在路易斯维尔对化学品进行综合调查，将探讨接触化学品对与心脏代谢疾病有关的健康结果的影响。UofL超级基金有害物质研究和培训项目的中心假设是，暴露于环境化学物质，挥发性有机化合物（VOCs）会导致/加剧胰岛素抵抗，导致心脏代谢疾病。我们的生物医学项目的初步结果提供了证据，表明肥胖使个体面临与挥发性有机化合物暴露相关的更高健康风险，而我们的非生物医学项目将解决缺乏系统测量工业区远端和近端居民暴露于这些化学物质的方法的问题。这个培训中心不仅将培训我们的博士后和博士研究员进行实验室研究，而且还将培训他们将研究成果有效地传达给超级基金研究项目中的其他人，以及整个社会。培训中心将为我们的学员开发研究生课程，与牛津大学工程学院、牙科学院、医学院、护理学院和文理学院共享，提供有关挥发性有机化合物的化学和人体健康影响的最新信息。培训中心还将为专业和本科培训项目做出贡献，为UofL的本科生物与化学荣誉学生、护理、牙科和医学学生以及杰斐逊县学校系统的教师和高中生提供研讨会演讲者或讲师，以交流化学暴露在人类疾病中的作用。最后，我们的学员将参加与西路易斯维尔特别工作组和地铁路易斯维尔公共卫生和健康部门的会议，与我们的社区参与和研究翻译核心一起讨论和回答有关超级基金研究项目的问题。每个受训者将被分配一个具体的项目，每个受训者将开发，以体验如何将研究成果转化为可以有效地传播给社区、各种地方/国家机构和大学听众的概念。

Abstract: Interdisciplinary research remains an important feature of the NIH Roadmap. An integrated investigation of chemicals in Louisville will address the effects of exposure on health outcomes related to cardiometabolic disease. The central hypothesis of the UofL Superfund Hazardous Substance Research and Training Project is that exposure to the environmental chemicals, volatile organic compounds (VOCs) causes/exacerbates insulin resistance, leading to cardio-metabolic disease. Preliminary results from our biomedical projects provide evidence that obesity places individuals at higher risk to adverse health outcomes related to VOCs exposures, while our non-biomedical projects will address the lack of methods to systematically measure exposure to these chemicals in residents distal and proximal to industrial areas. This Training Core will train our pre- and post-doctoral fellows not only in laboratory-based research, but also in effective communication of the research findings to others in the Superfund Research Projects, as well as to the Community at large. The Training Core will develop graduate courses for our Trainees to be shared with the UofL Schools of Engineering, Dentistry, Medicine and Nursing and the College of Arts & Sciences, providing the latest information about the chemistry and human health effects of volatile organic compounds. The Training Core also will contribute to the professional and undergraduate training programs by providing our trainees as seminar speakers or lecturers to UofL undergraduate Biology & Chemistry honors students, to nursing, dentistry, and medical students, and to teachers and high school students in the Jefferson County School System to communicate the role of chemical exposure in human disease. Finally, our trainees will participate in meetings with the West Louisville Task Force and the Metro Louisville Public Health and Wellness Department with our Community Engagement and Research Translation Cores to engage in discussion and answer questions about the Superfund research projects. Each trainee will be assigned a specific project that each trainee will develop in order to experience how to translate research findings into concepts that can be transmitted effectively to the community, various local/state agencies, and university audiences alike.