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Nonhuman Primate Testing Center for Evaluation of Somatic Cell Genome Editing Tools

非人类灵长类动物体细胞基因组编辑工具评估测试中心

基本信息

批准号：
9905568
负责人：
DAVID J SEGAL
金额：
$ 116.14万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-15 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9905568
关键词：
Address Animal Model Animal Testing Animals Benchmarking Biological Assay California Callithrix Center for Translational Science Activities Clinical Sciences Collaborations Communication Communities Development Ensure Evaluation Feedback Fostering Funding Future Genome Goals Governing Board Home environment Human Inflammation Infrastructure Leadership Macaca mulatta Methodology Modeling Office of Administrative Management Population Positioning Attribute Primates Procedures Process Publications Reagent Reporter Research Research Personnel Resources Safety Schedule Scientist Specificity System Technology Testing Translations United States National Institutes of Health Universities Work base data exchange experience genome editing human disease immunogenicity in vivo innovation meetings member multidisciplinary nonhuman primate organizational structure programs response somatic cell gene editing synergism tool working group

项目摘要

Overall PROJECT SUMMARY / ABSTRACT The University of California (UC) Davis Nonhuman Primate Testing Center for Evaluation of Somatic Cell Genome Editing Tools will support studies in nonhuman primates that will advance the genome editing field, and significantly contribute to the future translation of these technologies for the treatment of human disease. The Nonhuman Primate Testing Center brings together a robust team of multidisciplinary investigators with campus partnerships that capitalize on major strengths at UC Davis including the California National Primate Research Center, Genome Center, and Clinical and Translational Science Center. The Nonhuman Primate Testing Center will offer state-of-the-art capabilities for Somatic Cell Genome Editing (SCGE) awardees to conduct high quality research in nonhuman primates. The Nonhuman Primate Testing Center leverages a supportive framework that has demonstrated a long-standing commitment to providing research opportunities and collaborations to investigators nationwide. Through this powerful infrastructure the Nonhuman Primate Testing Center proposes the following Specific Aims: (1) Provide an administrative and organizational structure to advance somatic cell genome editing studies in nonhuman primates, (2) Foster partnerships with SCGE awardees through provision of resources that accelerate their research, and (3) Ensure synergism across the SCGE Program and Consortium via transparent interactions with the Dissemination and Coordinating Center, SCGE Working Group and Program Steering Committee, and the NIH. Our robust multidisciplinary team is poised to bring the depth and breadth of the UC Davis Nonhuman Primate Testing Center for Evaluation of Somatic Cell Genome Editing Tools to support SCGE investigators nationwide and contribute substantially to the Common Fund SCGE Program.

整体项目总结/摘要美国加州大学戴维斯分校非人灵长类动物体细胞评估测试中心基因组编辑工具将支持非人类灵长类动物的研究，这将推动基因组编辑领域的发展，并对这些技术在未来用于治疗人类疾病做出重大贡献。非人类灵长类动物检测中心汇集了一个强大的多学科研究团队，利用加州大学戴维斯分校的主要优势，包括加州国家灵长类动物园的校园合作伙伴关系研究中心，基因组中心，临床和转化科学中心。非人灵长类测试中心将为体细胞基因组编辑（SCGE）获奖者提供最先进的功能，在非人类灵长类动物中进行高质量的研究。非人类灵长类动物检测中心利用一个支持性框架，表明长期致力于提供研究机会与全国各地的调查人员合作通过这种强大的基础设施，考试中心提出以下具体目标：（1）提供一个行政和组织结构推进非人灵长类动物体细胞基因组编辑研究，（2）与SCGE建立伙伴关系通过提供资源，加速他们的研究，获奖者，（3）确保协同作用， SCGE计划和联盟通过与传播和协调中心的透明互动， SCGE工作组和项目指导委员会以及NIH。我们强大的多学科团队准备把加州大学戴维斯分校非人类灵长类动物测试中心的深度和广度，体细胞基因组编辑工具，以支持全国SCGE研究人员，并大大有助于共同基金SCGE计划。