Genome Editing and Biological Effects Testing Component

基因组编辑和生物效应测试组件

基本信息

  • 批准号:
    10773949
  • 负责人:
  • 金额:
    $ 65.19万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-09-01 至 2028-08-31
  • 项目状态:
    未结题

项目摘要

Genome Editing and Biological Effects Testing PROJECT SUMMARY / ABSTRACT The overarching goal of the Genome Editing and Biological Effects Testing Component of the Center for Somatic Cell Genome Editing in Nonhuman Primates is to test delivery reagents and editing tools developed by investigators in wild-type, reporter, and disease models. Studies performed will address the efficiency, specificity, and safety of genome editing technologies, including the duration of editing activity, and the potential for inflammation and immunogenicity. Nonhuman primates will be provided through the Resource Component, and the Coordination Component will ensure studies are well managed and prioritized, with efficient data collection, analysis, and sharing. The Genome Editing and Biological Effects Testing Component will work directly with investigators and utilize demonstrated capabilities to test a range of viral and nonviral vectors and contribute to the acceleration of the translation of somatic cell genome editing technologies into treatments for human diseases. The Genome Editing and Biological Effects Testing Component will address the following Specific Aims: (1) Evaluate somatic cell genome editing across age groups in nonhuman primates, and (2) Assess biological effects, safety, and the potential for inflammation and immune responses in nonhuman primate models. The Genome Editing and Biological Effects Testing Component team has the expertise and flexibility to work with investigators to quantify any desired type of genome editing event (e.g., on-target, off-target, large rearrangements, duration of editing, cell specificity), and in any organ system, cell population, or age group. Paired with a robust Resource Component, and through the infrastructure of the UC Davis Genome Center, California National Primate Research Center, and Clinical and Translational Science Center, the Genome Editing and Biological Effects Testing Component will deliver the data needed to comprehensively assess the promise of new somatic cell genome editing technologies developed by investigators.
基因组编辑和生物效应测试

项目成果

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专利数量(0)

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DAVID J SEGAL其他文献

DAVID J SEGAL的其他文献

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{{ truncateString('DAVID J SEGAL', 18)}}的其他基金

Innovative Translational Imaging Technologies to Monitor Genome Edited Cells in Vivo
用于监测体内基因组编辑细胞的创新转化成像技术
  • 批准号:
    10472034
  • 财政年份:
    2021
  • 资助金额:
    $ 65.19万
  • 项目类别:
Innovative Translational Imaging Technologies to Monitor Genome Edited Cells in Vivo
用于监测体内基因组编辑细胞的创新转化成像技术
  • 批准号:
    10447268
  • 财政年份:
    2021
  • 资助金额:
    $ 65.19万
  • 项目类别:
Nonhuman Primate Testing Center for Evaluation of Somatic Cell Genome Editing Tools: Equipment Supplement
非人类灵长类动物体细胞基因组编辑工具评估测试中心:设备补充
  • 批准号:
    10330336
  • 财政年份:
    2021
  • 资助金额:
    $ 65.19万
  • 项目类别:
Innovative Translational Imaging Technologies to Monitor Genome Edited Cells in Vivo
用于监测体内基因组编辑细胞的创新转化成像技术
  • 批准号:
    9810511
  • 财政年份:
    2019
  • 资助金额:
    $ 65.19万
  • 项目类别:
Genome Editing Testing Core
基因组编辑测试核心
  • 批准号:
    10380051
  • 财政年份:
    2019
  • 资助金额:
    $ 65.19万
  • 项目类别:
Nonhuman Primate Testing Center for Evaluation of Somatic Cell Genome Editing Tools
非人类灵长类动物体细胞基因组编辑工具评估测试中心
  • 批准号:
    9770048
  • 财政年份:
    2019
  • 资助金额:
    $ 65.19万
  • 项目类别:
Innovative Translational Imaging Technologies to Monitor Genome Edited Cells in Vivo
用于监测体内基因组编辑细胞的创新转化成像技术
  • 批准号:
    10017228
  • 财政年份:
    2019
  • 资助金额:
    $ 65.19万
  • 项目类别:
Genome Editing Testing Core
基因组编辑测试核心
  • 批准号:
    10599929
  • 财政年份:
    2019
  • 资助金额:
    $ 65.19万
  • 项目类别:
Nonhuman Primate Testing Center for Evaluation of Somatic Cell Genome Editing Tools
非人类灵长类动物体细胞基因组编辑工具评估测试中心
  • 批准号:
    9905568
  • 财政年份:
    2019
  • 资助金额:
    $ 65.19万
  • 项目类别:
Determinants of Persistence in Epigenetic Editing
表观遗传编辑持久性的决定因素
  • 批准号:
    9920184
  • 财政年份:
    2019
  • 资助金额:
    $ 65.19万
  • 项目类别:

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