Identification and characterization of factors affecting cytoskeletal proteins--the mediators of bacterial cell shape

影响细胞骨架蛋白的因素的鉴定和表征——细菌细胞形状的介质

基本信息

  • 批准号:
    9905535
  • 负责人:
  • 金额:
    $ 10.88万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-05-01 至 2022-04-30
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY In general, mediators of bacterial cell shape via the cytoskeleton are not well understood. We will explore the interplay of the cytoskeleton and cell shape based on three promising observations. First, we have identified a phospholipid synthase (CC1159) that, when overexpressed, causes the bacterium Caulobacter crescentus to change its shape from a crescent to a rod-shaped morphology by inhibiting the localization and function of the intermediate filament protein known as crescentin. Second, overexpression of a catalytically inactive version of the phospholipid synthase still mediates the change in cell shape, suggesting that the phenotype results from a protein-protein interaction instead of elevated levels of a phospholipid. Third, bacterial two-hybrid data suggest that our phospholipid synthase interacts with itself and with cytosine triphosphate synthase (CtpS), which also induces a rod-shaped morphology when overexpressed via interaction with crescentin. Human homologs of crescentin, the intermediate filament nuclear Lamins A/C, are implicated in premature aging and muscular dystrophy, and we suggest a link between phospholipid synthesis and intermediate filaments in C. crescentus that may parallel their human homologs. Research in the eukaryotic literature is just starting to link phospholipids/sphingolipids [and glycosylphosphatidylinositol-anchored proteins (GPI-AP)] with intermediate filaments, suggesting that our investigations in C. crescentus may be relevant to humans. Additionally, Helicobacter pylori's and Vibrio cholerae's crescent shape contributes to host colonization and pathogenesis. Thus, our findings may be also relevant to cell shape and pathogenicity of these human pathogens.
项目总结

项目成果

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Sean Murray其他文献

Sean Murray的其他文献

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{{ truncateString('Sean Murray', 18)}}的其他基金

Integrating lipid biosynthesis with bacterial cell cycle progression
将脂质生物合成与细菌细胞周期进程相结合
  • 批准号:
    8101422
  • 财政年份:
    2010
  • 资助金额:
    $ 10.88万
  • 项目类别:
Integrating lipid biosynthesis with bacterial cell cycle progression
将脂质生物合成与细菌细胞周期进程相结合
  • 批准号:
    7667987
  • 财政年份:
    2008
  • 资助金额:
    $ 10.88万
  • 项目类别:
Integrating lipid biosynthesis with bacterial cell cycle progression
将脂质生物合成与细菌细胞周期进程相结合
  • 批准号:
    7902214
  • 财政年份:
    2008
  • 资助金额:
    $ 10.88万
  • 项目类别:
Integrating lipid biosynthesis with bacterial cell cycle progression
将脂质生物合成与细菌细胞周期进程相结合
  • 批准号:
    7499199
  • 财政年份:
    2008
  • 资助金额:
    $ 10.88万
  • 项目类别:

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