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Core K: Translational Virology

核心 K：转化病毒学

基本信息

批准号：
9906067
负责人：
Sara Gianella Weibel
金额：
$ 34.99万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-04-01 至 2023-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9906067
关键词：
Acquired Immunodeficiency Syndrome Antibodies Area Basic Science Biological Biological Assay Blinded Blood Blood specimen Brain Cell Count Cell Survival Cerebrospinal Fluid Certification Clinical Clinical Sciences Collection Data Data Reporting Development E-learning Elements Ensure Funding Genomics Genotype Goals Grant HIV HIV Infections HIV-1 Individual Institutes International Laboratories Laboratory Procedures Leadership Leukapheresis Link Logistics Measures Methods Modernization Multilingualism Price Procedures Process Publications Quality Control Recovery Research Research Personnel Safety Sampling Services Shipping Ships Site Skin Source Specimen Specimen Handling Swab System Techniques Testing Training Training Activity Translating United States National Institutes of Health Urine Viral Load result Work base biobank clinical investigation clinically relevant cost cost effective design genital secretion lymph node biopsy member next generation nucleic acid detection procedure safety programs quality assurance rectal virology

项目摘要

Project Summary/Abstract Core K - Modern HIV research efforts require reliable links between clinical and basic science investigators. These links include characterization and access to clinical specimens, laboratory based assays designed for clinical specimens, interpretation and management of generated data, and training in these areas. The Translational Virology (TV) Core of the San Diego (SD) CFAR is designed to be this reliable and cost-effective link that provides added value to HIV research within our Center. The TV Core accomplishes this goal for a wide range of HIV research-related activities involving emerging and senior investigators, established and burgeoning programs, clinical and basic science investigators, domestic and international efforts, NIH and other funders, etc. Over the past 4 years, the TV Core has provided services to 199 investigators, contributed to 168 publications, supported investigators funded by 14 NIH institutes, and trained 127 individuals in safe laboratory procedures for working with HIV. Specifically, the TV Core provides services through four defined units that work closely with other CFAR Cores, as outlined: (1) Specimen Unit: obtains, processes, tracks, ships and cryostores samples. (Primary collaborating Core: Clinical Investigation Core). (2) Assay Unit: develops and provides a wide-range of clinically-relevant assays (HIV genotyping, viral loads, antibody and nucleic acid detection, etc.). (Primary collaborating Core: Genomics and Sequencing). (3) Quality Control Unit: provides quality control procedures for domestic and international CFAR-affiliated investigators, and analytical support for generated data. (Primary collaborating Core: BAM Cores). (4) Training Unit: provides training and certification in BL2 and BL3 safety and procedures, specimen processing, PCR, genotyping techniques, and laboratory quality assurance. (Primary collaborating Cores: Developmental and International Cores).

项目概要/摘要核心 K - 现代艾滋病毒研究工作需要临床和基础科学研究人员之间的可靠联系。这些链接包括临床标本的表征和获取、为以下目的而设计的基于实验室的测定临床标本、生成数据的解释和管理以及这些领域的培训。这圣地亚哥 (SD) CFAR 的转化病毒学 (TV) 核心旨在实现可靠且经济高效为我们中心内的艾滋病毒研究提供附加值的链接。 TV Core 实现了这一目标广泛的艾滋病毒研究相关活动，涉及新兴和高级研究人员，已建立和新兴项目、临床和基础科学研究人员、国内和国际努力、NIH 和其他资助者等在过去 4 年里，TV Core 为 199 名调查人员提供了服务，发表了 168 篇出版物，支持 14 个 NIH 机构资助的研究人员，并对 127 名人员进行安全实验室程序培训从事艾滋病毒工作。具体来说，电视核心通过四个紧密合作的定义单元提供服务与其他 CFAR 核心一起使用，如下所述： (1) 样本单元：获取、处理、跟踪、运输和冷冻样本。（主要协作核心：临床研究核心）。 (2) 检测单元：开发并提供广泛的临床相关检测（HIV 基因分型、病毒载量、抗体和核酸检测等）。（主要合作核心：基因组学和测序）。 (3) 质量控制单元：为国内和国际CFAR附属机构提供质量控制程序研究人员以及对生成数据的分析支持。（主要协作核心：BAM 核心）。 (4) 培训单位：提供BL2和BL3安全和程序、样本的培训和认证处理、PCR、基因分型技术和实验室质量保证。（主要协作核心：发展和国际核心）。