Core K: Translational Virology

核心 K：转化病毒学

• 批准号: 9906067
• 负责人: Sara Gianella Weibel
• 金额: $ 34.99万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9906067
• 关键词: Acquired Immunodeficiency Syndrome; Antibodies; Area; Basic Science; Biological; Biological Assay; Blinded; Blood; Blood specimen; Brain; Cell Count; Cell Survival; Cerebrospinal Fluid; Certification; Clinical; Clinical Sciences; Collection; Data; Data Reporting; Development; E-learning; Elements; Ensure; Funding; Genomics; Genotype; Goals; Grant; HIV; HIV Infections; HIV-1; Individual; Institutes; International; Laboratories; Laboratory Procedures; Leadership; Leukapheresis; Link; Logistics; Measures; Methods; Modernization; Multilingualism; Price; Procedures; Process; Publications; Quality Control; Recovery; Research; Research Personnel; Safety; Sampling; Services; Shipping; Ships; Site; Skin; Source; Specimen; Specimen Handling; Swab; System; Techniques; Testing; Training; Training Activity; Translating; United States National Institutes of Health; Urine; Viral Load result; Work; base; biobank; clinical investigation; clinically relevant; cost; cost effective; design; genital secretion; lymph node biopsy; member; next generation; nucleic acid detection; procedure safety; programs; quality assurance; rectal; virology

Project Summary/Abstract Core K - Modern HIV research efforts require reliable links between clinical and basic science investigators. These links include characterization and access to clinical specimens, laboratory based assays designed for clinical specimens, interpretation and management of generated data, and training in these areas. The Translational Virology (TV) Core of the San Diego (SD) CFAR is designed to be this reliable and cost-effective link that provides added value to HIV research within our Center. The TV Core accomplishes this goal for a wide range of HIV research-related activities involving emerging and senior investigators, established and burgeoning programs, clinical and basic science investigators, domestic and international efforts, NIH and other funders, etc. Over the past 4 years, the TV Core has provided services to 199 investigators, contributed to 168 publications, supported investigators funded by 14 NIH institutes, and trained 127 individuals in safe laboratory procedures for working with HIV. Specifically, the TV Core provides services through four defined units that work closely with other CFAR Cores, as outlined: (1) Specimen Unit: obtains, processes, tracks, ships and cryostores samples. (Primary collaborating Core: Clinical Investigation Core). (2) Assay Unit: develops and provides a wide-range of clinically-relevant assays (HIV genotyping, viral loads, antibody and nucleic acid detection, etc.). (Primary collaborating Core: Genomics and Sequencing). (3) Quality Control Unit: provides quality control procedures for domestic and international CFAR-affiliated investigators, and analytical support for generated data. (Primary collaborating Core: BAM Cores). (4) Training Unit: provides training and certification in BL2 and BL3 safety and procedures, specimen processing, PCR, genotyping techniques, and laboratory quality assurance. (Primary collaborating Cores: Developmental and International Cores).

项目摘要/摘要 核心K-现代艾滋病毒研究工作需要临床和基础科学研究人员之间的可靠联系。 这些链接包括表征和获取临床标本，基于实验室的分析设计用于 临床标本、生成数据的解释和管理以及这些领域的培训。这个 圣地亚哥(SD)CFAR的翻译病毒学(TV)核心设计为这种可靠且经济高效的 为我们中心内的艾滋病毒研究提供附加值的链接。电视核心实现了这一目标 与艾滋病毒研究有关的广泛活动，涉及新的和高级调查人员，已建立和 新兴项目，临床和基础科学研究人员，国内和国际努力，NIH和 其他资助人等 在过去的4年里，电视核心为199名调查人员提供了服务，为168份出版物做出了贡献， 支持由14个NIH研究所资助的研究人员，并培训127人进行安全实验室程序 因为他和艾滋病毒一起工作。具体地说，电视核心通过四个定义的密切合作的单位提供服务 对于CFAR的其他核心，如下所述： (1)标本单位：样品的获取、加工、跟踪、运输和冷藏。(主要协作核心： 临床调查核心)。 (2)化验股：开发和提供广泛的临床相关化验(艾滋病毒基因分型、病毒载量、 抗体和核酸检测等)。(主要合作核心：基因组学和测序)。 (3)质量控制组：为国内和国际CFAR附属机构提供质量控制程序 调查人员，以及对生成的数据的分析支持。(主要协作核心：BAM核心)。 (4)训练组：提供有关BL2和BL3安全和程序的培训和认证，样本 加工、聚合酶链式反应、基因分型技术和实验室质量保证。(主要协作核心： 发展核心和国际核心)。