Core K: Translational Virology

核心K：翻译病毒学(TV)项目摘要/摘要 新的病毒学技术彻底改变了人们对艾滋病毒传播、持久性和 发病机制。翻译病毒学(TV)核心的总体目标是为SD CFAR研究人员提供 拥有病毒学专业知识和为艾滋病毒研究量身定做的先进实验室技术。电视核心将最大化 访问专门的分析，开发数据处理工具，确保最高质量的结果，并提供 为下一代艾滋病毒研究人员提供了极好的培训。艾滋病毒研究工作需要可靠的联系和 畅通临床和基础科学研究人员之间的沟通。SD CFAR的电视核心一直是 创建、发展和改进以实现这些目标。 增强的SD CFAR电视核心将通过四个定义的单位提供服务，这些单位与其他 SD CFAR核心，通过我们的具体目标概述： 1.化验股：提供病毒学专业知识和一系列专门的病毒学分析，其基础是 SD CFAR调查人员的研究需求。 2.数据处理股：在执行新的数据处理方面提供计算专门知识 病毒学数据管道，与生物统计和建模核心协调。 3.培训股：提供病毒学程序方面的培训，并协助开发下一代 艾滋病毒研究人员，特别是那些来自代表性不足的背景的人。 4.质量保证单位：确保我们服务的质量、标准化和完整性。 为即将到来的更新而进行的核心重组表明，我们致力于提供最好的科学和 为我们所有的合作者提供服务。核心的四大支柱：专业知识、创新、协作和指导 为所有研究人员和项目提供示范实验室支持服务。具体到这次续订， 提议的新的和扩展的电视核心将最大限度地提高效率，并通过提供所有病毒学来消除重叠 “同一屋檐下”的专业知识和技术。这个新组织旨在成为最可靠、成本最低的组织- 有效的链接，为我们中心内的艾滋病毒研究提供附加值，同时加强合作 以及与其他SD CFAR核心的通信。 扩大的电视核心将把我们中心的基础和临床科学研究人员聚集在一起并建立联系 它们与其他SD CFAR核心一起实现以下关键目标：1)提供针对艾滋病毒的专门知识；2) 降低病毒学研究的成本壁垒；3)支持新数据的数据处理流水线 4)培训新一代艾滋病毒研究人员。

Core K: Translational Virology (TV) Project Summary/Abstract New virological technologies have revolutionalized the understanding of HIV transmission, persistence, and pathogenesis. The overall objective of the Translational Virology (TV) Core is to provide SD CFAR researchers with virologic expertise and advanced laboratory techniques tailored to HIV research. The TV Core will maximize access to specialized assays, develop data processing tools, ensure the highest quality results, and provide excellent training for the next generation of HIV researchers. HIV research efforts require reliable links and smooth communication between clinical and basic science investigators. The TV Core of the SD CFAR has been created, developed, and improved to achieve these objectives. The enhanced SD CFAR TV Core will provide services through four defined units that work closely with other SD CFAR cores, as outlined through our specific aims: 1. Assay Unit: To provide virologic expertise and a diverse array of specialized virologic assays based on the research needs of SD CFAR investigators. 2. Data Processing Unit: To provide computational expertise in the implementation of new data processing pipelines for virologic data, in concert with the Biostatistics and Modeling Core. 3. Training Unit: To provide training in virologic procedures and assist in the development of the next generation of HIV researchers, particularly those from underrepresented backgrounds. 4. Quality Assurance Unit: To ensure the quality, standardization, and integrity of our services. The Core’s restructuring for the upcoming renewal illustrates our commitment to providing the best science and services to all our collaborators. The Core’s four pillars of expertise, innovation, collaboration, and mentoring provide exemplary laboratory support services for all researchers and projects. Specific to this renewal, the proposed new and expanded TV Core will maximize efficiency and eliminate overlap by offering all virologic expertises and technologies ‘under one roof’. This new organization is designed to be the most reliable and cost- effective link that provides added value to HIV research within our Center while strengthening the collaboration and communication with the other SD CFAR cores. The expanded TV Core will bring our Center’s basic and clinical science researchers together and connects them with other SD CFAR cores to achieve the following key objectives: 1) Providing HIV-specific Expertise, 2) Lowering the Cost Barrier to Virologic Research, 3) Supporting Data Processing Pipelines through the new Data Processing Unit, and 4) Training the New Generation of HIV Researchers.