Project 002 - VIDI

项目 002 - VIDI

基本信息

项目摘要

PROJECT 2. Viral Immunology, Drugs, and Imaging (VIDI) Research Project - ABSTRACT Despite the success of antiretroviral therapy (ART) improving the lives of persons with HIV (PWH), curing HIV would be important to reduce stigma and long-term co-morbidities associated with HIV infection that occur even during ART. Developing a successful cure will need to better identify the viral and host factors that govern HIV dynamics in its HIV Obligate MicroEnvironment (HOME) to identify reservoir vulnerabilities that can be targeted. The Viral Immunology, Drugs, and Imaging (VIDI) Research Project (RP) will focus on immune, pharmacological, host epigenetic cellular environments, and tissue architecture that govern the continuum of HIV reservoir dynamics. This characterization by the VIDI RP alone will add considerable new knowledge to the field. In the HOME program, these assay results will be integrated with viral features of HIV reservoir dynamics characterized by VENI RP, and all datasets will be further integrated and analyzed by VICI RP. For experimental planning, the HIV reservoir dynamic continuum is simplified as the following reservoir states: · Leaves HOME when HIV (re)activates from tissues during antiretroviral therapy (ART) (i.e., like packing its bag and getting ready to leave) and causes rebound viremia during ART interruption. · Comes HOME when HIV (re)populates tissues during viremia off ART and through the spread of clonally expanded HIV-infected cells while on ART. (Clonal expansion is like adding family to the home.) · Stays HOME when HIV (silently) persists in blood and tissue reservoirs (on and off ART). To optimize allocated resources, we developed a two-step Adaptive Learning Approach. During the Mapping phase, the VIDI RP will examine how cellular and soluble inflammatory milieus and ART levels are associated with each reservoir state (i.e., leaving, coming, staying). The VICI RP will assist in the integration and analysis of these data to identify ‘samples-of-interest’ that have pre-defined reservoir states and sufficient cellular environment for deeper investigation. In the Confirmation phase, the VIDI RP will use single-cell and imaging technologies to further characterize environmental factors associated with reservoir dynamics at a deeper level. Importantly, the feasibility of our VIDI RP is greatly enhanced by the knowledge gained from our previous P01 (AI131385) and its Last Gift Cohort, which collects pre- and post- mortem specimens from PWH who did (n=5) or did not stop ART (n=15) before death. The HOME program will allow the continuation of this cohort while expanding the science to study HIV dynamics across the human body at the single-genome and single-cell level. In summary, the overall HOME program will provide a deep delineation of environmental factors governing HIV reservoir dynamics, which is directly responsive to the Understanding HIV Reservoir Dynamics RFA AI-21-013. This new knowledge will inform HIV cure strategies aiming at reversing latency (“Shock and Kill”) or at silencing permanently deep reservoirs (“Block and Lock”) and provide new insights in ways to reduce local HIV-associated tissue damage, which has been implicated in inflammation-related illnesses.
项目2。病毒免疫学,药物和成像(VIDI)研究项目-摘要

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Sara Gianella Weibel其他文献

Sara Gianella Weibel的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Sara Gianella Weibel', 18)}}的其他基金

Sex-differences in HIV persistence and Immune Dynamics during Reproductive Aging
生殖衰老过程中艾滋病毒持久性和免疫动态的性别差异
  • 批准号:
    10838316
  • 财政年份:
    2023
  • 资助金额:
    $ 67.56万
  • 项目类别:
Project 002 - VIDI
项目 002 - VIDI
  • 批准号:
    10459875
  • 财政年份:
    2022
  • 资助金额:
    $ 67.56万
  • 项目类别:
Impact of Reproductive Aging On HIV Persistence and Inflammation
生殖衰老对艾滋病毒持续性和炎症的影响
  • 批准号:
    10433074
  • 财政年份:
    2021
  • 资助金额:
    $ 67.56万
  • 项目类别:
Core K: Translational Virology
核心 K:转化病毒学
  • 批准号:
    9906067
  • 财政年份:
    2020
  • 资助金额:
    $ 67.56万
  • 项目类别:
Mechanisms of CMV Replication on HIV Persistence
CMV 复制对 HIV 持续存在的机制
  • 批准号:
    10012877
  • 财政年份:
    2020
  • 资助金额:
    $ 67.56万
  • 项目类别:
The HIV-associated Opioid Micro-Environment (HOME) Project
HIV 相关阿片类药物微环境 (HOME) 项目
  • 批准号:
    10056153
  • 财政年份:
    2020
  • 资助金额:
    $ 67.56万
  • 项目类别:
Mechanisms of CMV Replication on HIV Persistence
CMV 复制对 HIV 持续存在的机制
  • 批准号:
    10241944
  • 财政年份:
    2020
  • 资助金额:
    $ 67.56万
  • 项目类别:
Mechanisms of CMV Replication on HIV Persistence
CMV 复制对 HIV 持续存在的机制
  • 批准号:
    10448351
  • 财政年份:
    2020
  • 资助金额:
    $ 67.56万
  • 项目类别:
Effect of Declining Sex Hormones on HIV persistence in HIV Infected Women on ART
性激素下降对接受 ART 的 HIV 感染妇女中 HIV 持续存在的影响
  • 批准号:
    9568360
  • 财政年份:
    2017
  • 资助金额:
    $ 67.56万
  • 项目类别:
Effect of Declining Sex Hormones on HIV persistence in HIV Infected Women on ART
性激素下降对接受 ART 的 HIV 感染妇女中 HIV 持续存在的影响
  • 批准号:
    9482258
  • 财政年份:
    2017
  • 资助金额:
    $ 67.56万
  • 项目类别:

相似海外基金

Practical Study on Disaster Countermeasure Architecture Model by Sustainable Design in Asian Flood Area
亚洲洪泛区可持续设计防灾建筑模型实践研究
  • 批准号:
    17K00727
  • 财政年份:
    2017
  • 资助金额:
    $ 67.56万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Functional architecture of a face processing area in the common marmoset
普通狨猴面部处理区域的功能架构
  • 批准号:
    9764503
  • 财政年份:
    2016
  • 资助金额:
    $ 67.56万
  • 项目类别:
Heating and airconditioning by hypocausts in residential and representative architecture in Rome and Latium studies of a phenomenon of luxury in a favoured climatic area of the Roman Empire on the basis of selected examples.
罗马和拉齐奥的住宅和代表性建筑中的火烧供暖和空调根据选定的例子,研究了罗马帝国有利的气候地区的奢华现象。
  • 批准号:
    317469425
  • 财政年份:
    2016
  • 资助金额:
    $ 67.56万
  • 项目类别:
    Research Grants
SBIR Phase II: Area and Energy Efficient Error Floor Free Low-Density Parity-Check Codes Decoder Architecture for Flash Based Storage
SBIR 第二阶段:用于基于闪存的存储的面积和能源效率高、无错误层的低密度奇偶校验码解码器架构
  • 批准号:
    1632562
  • 财政年份:
    2016
  • 资助金额:
    $ 67.56万
  • 项目类别:
    Standard Grant
SBIR Phase I: Area and Energy Efficient Error Floor Free Low-Density Parity-Check Codes Decoder Architecture for Flash Based Storage
SBIR 第一阶段:用于基于闪存的存储的面积和能源效率高、无错误层低密度奇偶校验码解码器架构
  • 批准号:
    1520137
  • 财政年份:
    2015
  • 资助金额:
    $ 67.56万
  • 项目类别:
    Standard Grant
A Study on The Spatial Setting and The Inhavitant's of The Flood Prevention Architecture in The Flood Area
洪泛区防洪建筑空间设置及居民生活研究
  • 批准号:
    26420620
  • 财政年份:
    2014
  • 资助金额:
    $ 67.56万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Area and power efficient interconnect architecture for multi-bit processing on FPGAs
用于 FPGA 上多位处理的面积和功率高效互连架构
  • 批准号:
    327691-2007
  • 财政年份:
    2011
  • 资助金额:
    $ 67.56万
  • 项目类别:
    Discovery Grants Program - Individual
A FUNDAMENTAL STUDY ON UTILIZATION OF THE POST-WAR ARCHITECTURE AS URBAN REGENERATION METHOD, A case of the central area of Osaka city
战后建筑作为城市更新方法的基础研究——以大阪市中心区为例
  • 批准号:
    22760469
  • 财政年份:
    2010
  • 资助金额:
    $ 67.56万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Area and power efficient interconnect architecture for multi-bit processing on FPGAs
用于 FPGA 上多位处理的面积和功率高效互连架构
  • 批准号:
    327691-2007
  • 财政年份:
    2010
  • 资助金额:
    $ 67.56万
  • 项目类别:
    Discovery Grants Program - Individual
Area and power efficient interconnect architecture for multi-bit processing on FPGAs
用于 FPGA 上多位处理的面积和功率高效互连架构
  • 批准号:
    327691-2007
  • 财政年份:
    2009
  • 资助金额:
    $ 67.56万
  • 项目类别:
    Discovery Grants Program - Individual
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了