2020 Marine Natural Products Gordon Research Conference and Gordon Research Seminar

2020年海洋天然产物戈登研究大会暨戈登研究研讨会

• 批准号: 9907017
• 负责人: Kerry Leigh McPhail
• 金额: $ 2.8万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-12-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9907017
• 关键词: Academia; Address; Affinity; Anabolism; Area; Basic Science; Bioinformatics; Biological; Biology; California; Cell physiology; Chemicals; Collaborations; Communicable Diseases; Computational Science; Cryoelectron Microscopy; Data; Development; Disabled Persons; Disease; Educational workshop; Environment; Equilibrium; Female; Gender; Gene Cluster; Genetic; Genome; Genomics; Goals; Government; Health; Hour; Human; Individual; Industrialization; Industry; International; Ligands; Malignant Neoplasms; Mass Spectrum Analysis; Medicine; Methodology; Mining; Molecular; Molecular Genetics; Molecular Structure; Molecular Target; Natural Products; Oral; Organism; Outcome; Pain; Participant; Pathway interactions; Phenotype; Physiology; Postdoctoral Fellow; Production; Research; Research Personnel; Roentgen Rays; Role; Science; Scientist; Source; Structure; Students; System; Techniques; Technology; Training; Underrepresented Groups; Underrepresented Minority; United States National Institutes of Health; Woman; Work; bioactive natural products; biological systems; career; career development; clinical application; educational atmosphere; empowerment; experience; graduate student; human disease; immune function; macromolecule; marine natural product; marine organism; meetings; metabolomics; nervous system disorder; new technology; novel; novel strategies; pathogen; posters; preclinical development; programs; scaffold; symposium; therapy design; tool; training opportunity

Project Summary Natural products research is undergoing a transformative period driven by genomics, advances in our understanding of the molecular genetics of natural product biosynthesis, chemical biology solutions to identifying molecular targets and mechanism of action, and new analytical techniques for molecular structure determination. In particular, natural products from marine organisms have delivered unique molecular scaffolds that interact with cellular macromolecules and pathways, altering phenotype and physiology in ways not seen by molecules from other sources. In addition to informing scientists of how biological systems function, the role of natural products as ligands with highly specific affinities for disease-relevant targets has presented opportunities for designing therapies for human disease including cancer, neurological disorders, and many infectious pathogens. With this proposal, support is requested for the 2020 Marine Natural Products Gordon Research Seminar (GRS) and Gordon Research Conference (GRC) to be held in Ventura, California on February 22-28, 2020. The GRS is a unique forum for graduate students and postdocs to present and exchange new data and cutting-edge ideas encompassing the field of marine natural products with applications that range from basic science discoveries to human health impacts. The GRC will bring together early career and established researchers from academia, industry, and government (including all of the GRS participants) to address the discovery, characterization and functional development of marine natural products. Presentations and discussion will focus on how natural products modulate cellular processes and present opportunities to treat human disease; applications of natural product research to medicine and marine conservation; cutting-edge techniques in natural product structure elucidation, synthesis, and determination of modes of action; and the biosynthetic origin of marine natural products including genome mining, heterologous expression, and genetic advances to facilitate the expression of silent gene clusters. Graduate students and postdocs will gain experience in poster and oral presentations at the short-format GRS immediately prior to the GRC, and thus be poised to develop career opportunities and new collaborations during the GRC via direct interaction with established leaders in the field. The collegial atmosphere of the GRS and GRC will facilitate new research directions and training opportunities for early career scientists, and the exchange of ideas among leaders in the field and new participants. NIH support will be directed towards participation of graduate student and postdoctoral presenters and discussion leaders at the GRS and GRC, and female and under-represented minority presenters at the GRC.

项目摘要 天然产物研究正在经历一个由基因组学驱动的变革时期，我们的研究进展 了解天然产物生物合成的分子遗传学，化学生物学解决方案， 确定分子靶点和作用机制，以及分子结构的新分析技术 保持战略定力特别是，来自海洋生物的天然产物提供了独特的分子支架 与细胞大分子和通路相互作用，以前所未有的方式改变表型和生理学 其他来源的分子。除了让科学家了解生物系统的功能， 天然产物作为配体与疾病相关的目标具有高度特异性的亲和力， 为人类疾病设计治疗方法的机会，包括癌症，神经系统疾病，以及许多 传染性病原体根据这一建议，要求支持2020年海洋天然产品戈登 研究研讨会（GRS）和戈登研究会议（GRC）将在文图拉，加州举行， 2020年2月22日至28日。GRS是一个独特的论坛，供研究生和博士后介绍和 交流涵盖海洋天然产品领域的新数据和前沿想法及其应用 从基础科学发现到人类健康影响。GRC将汇集早期职业生涯 以及来自学术界、工业界和政府的研究人员（包括所有GRS参与者） 解决海洋天然产品的发现、特性描述和功能开发问题。 演讲和讨论将集中在天然产物如何调节细胞过程和呈现 治疗人类疾病的机会;天然产物研究在医药和海洋中的应用 保护;天然产物结构解析、合成和测定的尖端技术 作用方式;以及海洋天然产品的生物合成来源，包括基因组挖掘、异源 表达，以及促进沉默基因簇表达的遗传进展。研究生和 博士后将获得海报和口头报告的经验，在短期格式GRS之前， GRC，因此准备通过直接在GRC期间开发职业机会和新的合作 与该领域的知名领导人互动。GRS和GRC的学院氛围将有助于 为早期职业科学家提供新的研究方向和培训机会， 该领域的领导者和新的参与者。NIH的支持将针对研究生的参与 研究生院和研究生院的博士后演讲者和讨论领导人，以及女性和代表人数不足的人 少数民族代表在GRC。