2022 Marine Natural Products Gordon Research Conference and Seminar

项目摘要 天然产物研究为人类的健康和福祉做出了巨大贡献，提供了独特的 动物健康和农业以及人类疾病治疗方面的机会，这项工作就是例证 诺贝尔奖获得者屠呦呦(抗疟疾青蒿素)中村(抗寄生虫阿维菌素)。这个 天然产物作为潜在的多功能配体的进化具有高度特异的疾病亲和力- 相关目标为开发癌症、传染病和 尤其是神经性疾病。来自海洋环境的天然产品提供了独特的 与细胞大分子和信号通路相互作用的分子支架 表型和生理上不同于由其他来源的分子引起的。多元组学时代 天然产物生物合成的分子遗传学和分析技术的变革性进展 为了在复杂生物系统的背景下描述自然产品的特征，可以进一步利用 结合机器学习的计算工具，用于加速和及早确定天然产物 结构和生物功能。2022年海洋天然产物戈登研究研讨会(GRS)和 戈登研究会议(GRC)计划于2022年3月6日至11日在加利福尼亚州文图拉举行。GRS是一项 为研究生和博士后提供和交流新数据和创新想法的独特论坛 为人类健康和福祉而进行的海洋天然产品基础和应用研究的范围。GRC将 汇聚来自学术界、工业界和政府的早期职业和知名研究人员(包括所有 GRS参与者)，讨论海洋天然生物的发现、特征和功能开发 产品。演讲和讨论将涉及生物活性天然产品的分子靶标， 包括自然产物机制的超分辨率分子成像；计算方法 从复杂混合物中发现功能性天然产物.天然产物的表型筛选 发现、天然产物工程的合成生物学、天然产物铅的合成策略 开发、临床开发中的海洋天然产品，以及气候变化和环境解决方案。 研究生和博士后将在短期格式的GRS中获得海报和口头演示的经验 就在GRC之前，并因此准备在以下期间开发职业机会和新的合作 GRC通过与该领域老牌领导者的直接互动。GRS和GRS的大学氛围 GRC将促进创新合作，为科学学科和领导人之间的思想交流架起桥梁 在现场和新的参与者。NIH的支持将针对研究生和 GRS和GRC的博士后演讲者和讨论领袖，以及GRC的女性演讲者 或者来自代表不足的群体。

Project Summary Natural products research has contributed tremendously to human health and well-being, providing unique opportunities in animal health and agriculture as well as human disease treatment, as exemplified by the work of Nobel Laureates Tu Youyou (anti-malarial artemisinin) Satoshi Õmura (anti-parasitic avermectin). The evolution of natural products as potentially multifunctional ligands with highly specific affinities for disease- relevant targets has provided opportunities to develop therapeutic agents for cancers, infectious diseases and neurological disorders in particular. Natural products from the marine environment have provided unique molecular scaffolds that interact with cellular macromolecules and signaling pathways to effect changes in phenotype and physiology distinct from those caused by molecules from other sources. Multi-omics era transformational advances in the molecular genetics of natural product biosynthesis, and analytical technologies for characterizing natural products in the context of complex biological systems, stand to be leveraged further by computational tools that incorporate machine learning for accelerated and early determination of natural product structure and biological function. The 2022 Marine Natural Products Gordon Research Seminar (GRS) and Gordon Research Conference (GRC) is planned for March 6-11, 2022, in Ventura, California. The GRS is a unique forum for graduate students and postdocs to present and exchange new data and innovative ideas across the scope of basic and applied marine natural products research for human health and well-being. The GRC will bring together early career and established researchers from academia, industry, and government (including all of the GRS participants) to address the discovery, characterization and functional development of marine natural products. Presentations and discussion will address the molecular targets of biologically active natural products, including super resolution molecular imaging for natural product mechanisms; computational approaches to functional natural products discovery from complex mixtures; phenotypic screening for natural products discovery, synthetic biology for natural product engineering, synthetic strategies for natural product lead development, marine natural products in clinical development, and climate change and environmental solutions. Graduate students and postdocs will gain experience in poster and oral presentations at the short-format GRS immediately prior to the GRC, and thus be poised to develop career opportunities and new collaborations during the GRC via direct interaction with established leaders in the field. The collegial atmosphere of the GRS and GRC will foster innovative collaborations that bridge scientific disciplines and exchange of ideas among leaders in the field and new participants. NIH support will be directed towards participation of graduate student and postdoctoral presenters and discussion leaders at the GRS and GRC, as well as GRC presenters who are female and or from under-represented groups.