Abdominal adipose tissue depots and cardiometabolic disease risk in postmenopausal women

绝经后女性腹部脂肪组织库和心脏代谢疾病风险

• 批准号: 9906162
• 负责人: Andrew Owen Odegaard
• 金额: $ 24.83万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-15 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9906162
• 关键词: Abdomen; Address; Adipose tissue; Age; Atrial Fibrillation; Basic Science; Benign; Body Composition; Body fat; Cardiovascular Diseases; Clinic; Clinical; Clinical Research; Congestive Heart Failure; Coronary heart disease; Deposition; Diet; Dietary intake; Disease; Disease Outcome; Dual-Energy X-Ray Absorptiometry; Dyslipidemias; Epidemiology; Ethnic Origin; Event; Functional disorder; Gold; Hypertension; Imaging Techniques; Insulin Resistance; Intervention; Intra-abdominal; Knowledge; Longitudinal cohort; Magnetic Resonance Imaging; Measurement; Measures; Metabolic; Methods; Minority; Nature; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Participant; Pattern; Peripheral arterial disease; Physical activity; Play; Population Research; Positioning Attribute; Postmenopause; Prevention; Radiation; Research; Research Personnel; Resources; Risk; Role; Sample Size; Sampling; Scanning; Sleep; Sleep disturbances; Slice; Stroke; Subcutaneous Tissue; Technology; Thinness; Time; Validation; Visceral; Visit; Woman; Women' s Health; X-Ray Computed Tomography; abdominal fat; cardiometabolic risk; cardiometabolism; cohort; cost; disorder prevention; disorder risk; evidence base; experience; follow-up; insight; interest; lumbar vertebra bone structure; new technology; prospective; research study; sleep pattern; standard measure; subcutaneous; waist circumference

PROJECT SUMMARY Accumulating basic, clinical, and population research suggests that high amounts of abdominal fat, particularly visceral adipose tissue (VAT) in the intra-abdominal depot, plays a crucial role in the pathophysiology of cardiometabolic diseases (i.e. type 2 diabetes (T2D), cardiovascular diseases (CVD) and stroke). This research has elegantly described the intimate nature of VAT as a powerful metabolic driver of insulin resistance, dyslipidemia, and hypertension. It also suggests that total body fat, and more specifically subcutaneous adipose tissue (SAT), may be relatively less important or even benign in the pathophysiology of cardiometabolic disease. Despite this burgeoning framework of knowledge, much remains unknown about the relationship between abdominal VAT and SAT levels with incident cardiometabolic disease events – a critical gap in the evidence base since further insight resulting from research on this topic would have major implications related to the importance of body composition and obesity in cardiometabolic disease prevention. The central reason for the bottleneck in the evidence base has been feasibility. Researchers and clinicians have had to rely on imaging techniques such as computed tomography (CT) and magnetic resonance imaging (MRI) to measure specific adipose tissue depots. Issues such as cost, radiation, and availability have made these methods impractical in the clinic and for large research studies; and the few studies which have incorporated these technologies may have limited sample size, or have not accrued enough follow up time and events to adequately address the topic. However, there is an efficient and economical solution to this problem via the application of new technology that quantifies abdominal VAT and SAT from existing Dual Energy X-Ray Absorptiometry (DXA) scans. This technology has demonstrated strong validity with gold-standard measures of abdominal adipose tissue depots from MRI and CT scans. Therefore, we propose to apply this novel technology to the existing Women's Health Initiative (WHI) DXA cohort to quantify abdominal VAT and SAT from existing DXA scans. This proposal will create a valuable, new, minority enriched, analytic longitudinal cohort that will utilize repeated DXA measurements in the WHI at baseline (N=10,607), year 3 (N=8,939), year 6 (N=8,239), and year 9 (N=4,595) to address essential questions on the topic of abdominal adiposity/body composition, and cardiometabolic disease risk in postmenopausal women as they age. This project capitalizes on a rich scientific resource and will provide new and advanced results that will delineate the importance of abdominal adipose tissue depots in cardiometabolic disease risk and the potential for targeted interventions and prevention efforts.

项目摘要 累积的基础、临床和人口研究表明，大量的腹部脂肪，特别是 内脏脂肪组织（VAT）在腹腔内的仓库，发挥了至关重要的作用，在病理生理学 心脏代谢疾病（即2型糖尿病（T2 D）、心血管疾病（CVD）和中风）。这 研究优雅地描述了VAT作为胰岛素强大代谢驱动器的亲密性质 抵抗、血脂异常和高血压。它还表明，总的身体脂肪，更具体地说， 皮下脂肪组织（SAT）在肿瘤的病理生理学中可能相对不那么重要，甚至是良性的。 心脏代谢疾病尽管有了这个新兴的知识框架， 腹部VAT和SAT水平与心血管代谢疾病事件的关系-一个关键的 证据基础的差距，因为对这一主题的研究所产生的进一步见解将具有重大意义 与身体组成和肥胖在心脏代谢疾病预防中的重要性相关的意义。 证据库瓶颈的主要原因是可行性。研究人员和临床医生 不得不依靠成像技术，如计算机断层扫描（CT）和磁共振成像 (MRI)来测量特定的脂肪组织。成本、辐射和可用性等问题使得 这些方法在临床和大型研究中是不切实际的; 纳入这些技术的样本量可能有限，或者没有积累足够的随访时间， 事件，以充分解决这个问题。然而，有一个有效和经济的解决方案，这个问题 通过应用新技术，从现有的双能X射线中量化腹部VAT和SAT 吸收测定法（DXA）扫描。这项技术已经证明了强大的有效性与黄金标准的措施， 腹部脂肪组织库从MRI和CT扫描。因此，我们建议将这部小说 现有的妇女健康倡议（WHI）DXA队列技术，以量化腹部VAT和SAT 从现有的DXA扫描。这一建议将创造一个有价值的，新的，少数民族丰富，分析纵向 队列将在基线（N= 10，607）、第3年（N= 8，939）、第4年（N= 10，607）和第5年（N= 10，607）时在WHI中使用重复DXA测量。 6年（N= 8，239）和9年（N= 4，595），以解决腹部肥胖/身体主题的基本问题 绝经后妇女随着年龄的增长，心脏代谢疾病的风险。该项目资本化 丰富的科学资源，并将提供新的和先进的结果，将描绘的重要性， 腹部脂肪组织在心脏代谢疾病风险中的储存和靶向干预的可能性 和预防工作。