Novel Analyses of Abdominal Computed Tomography Data in CARDIA

 描述（由申请人提供）：在动物和人类中积累的临床研究表明，大量的腹部脂肪，特别是腹部内器官（内脏脂肪和肝脏脂肪）内和周围的脂肪，在糖尿病和心血管疾病的风险中起着至关重要的作用。然而，目前还没有大型流行病学研究调查生活方式对这些腹部脂肪储存的作用。到目前为止，很少有流行病学队列研究包括来自大样本社区参与者的腹腔内脂肪库的详细测量。本申请中提出的研究使用现有的NHLBI数据集来填补一系列严格分析中的这些证据空白。NHLBI年轻人冠状动脉风险发展（CARDIA）研究包括对饮食和久坐行为的详细评估，以及通过计算机断层扫描成像评估的4个腹部脂肪库（皮下，内脏，肌内和肝脏），这些评估在美国4个大都市地区进行了25年的随访，共3，170名非洲裔美国人和高加索人。该数据集还提供了丰富的人口统计和心理社会因素，可作为潜在的混杂因素进行评估。我们建议通过分析成年非裔美国人和白人男性和女性的CARDIA数据来解决以下三个具体目标：1）描述久坐不动的生活习惯和腹内脂肪库之间的关联。2)描述饮食模式与肝脏脂肪之间的关联。3)基于用于研究和转化为临床实践的常用临床测量组合，开发内脏脂肪体积的预测模型。这些分析将奠定 我们将在未来的应用中向NIH提出未来研究的几个领域的基础，包括前瞻性研究和基于社区的干预研究。这种转化研究旨在改变生活方式，以改善身体成分为目标，这对慢性病一级和二级预防的科学和公共卫生进展至关重要。

 DESCRIPTION (provided by applicant): Accumulating clinical research in animals and humans suggests that high amounts of abdominal fat, particularly within and around the organs inside the abdomen (visceral fat and liver fat), plays a crucial role in risk for diabetes and cardiovascular diseases. However, there have been no large epidemiologic studies examining the role of lifestyle on these abdominal fat stores. Until now, few, if any, epidemiologic cohort studies have included detailed measures of intra-abdominal fat depots from a large sample of community- based participants. The study proposed in this application uses an existing NHLBI dataset to fill these evidence gaps in a series of rigorous analyses. The NHLBI Coronary Artery Risk Development in Young Adults (CARDIA) Study includes detailed assessments of dietary and sedentary behaviors, as well as four abdominal fat depots (subcutaneous, visceral, intramuscular, and hepatic) assessed by computed tomography imaging in 3,170 African American and Caucasian adults that have been followed for 25 years in four U.S. metropolitan regions. The data set also provides a rich array of demographic and psychosocial factors that can be assessed as potential confounding factors. We propose to address the following three specific aims through analyses of CARDIA data in adult African American and Caucasian men and women: 1) Describe the associations between sedentary lifestyle habits and intra-abdominal fat depots. 2) Describe the associations between dietary patterns and hepatic fat. 3) Develop a prediction model for visceral fat volume based upon a combination of common clinical measures for use in research and translation to clinical practice. These analyses will lay the foundation for several areas of future research that we will propose to NIH in future applications, including prospective studies and community-based intervention studies. Such translational research geared towards changing lifestyle with the goal of improving body composition will be crucial towards scientific and public health progress in primary and secondary prevention of chronic diseases.