Mapping learning-dependent remodelling of synapse balance across the brain

绘制大脑突触平衡的学习依赖性重塑

• 批准号: nhmrc : GNT1163504
• 金额: $ 73.57万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mapping-learning-dependent-balance-brain/1379303
• 关键词: Mapping; learning; dependent; remodelling; synapse

This project will elucidate how the brain remodels the balance of excitatory ‘go’ and inhibitory ‘stop’ connections and how disrupted balance underlies maladaptive behaviour in autism spectrum disorders. Combining an international team with innovative behavioural and imaging methods, we will establish a platform for imaging individual brain connections across whole mouse brains, bridging current methods in worldwide initiatives mapping brain connectivity at different scales in animals to humans.

该项目将阐明大脑如何重塑兴奋性“走”和抑制性“停止”连接的平衡，以及平衡被破坏如何导致自闭症谱系障碍的适应不良行为。将国际团队与创新的行为和成像方法相结合，我们将建立一个平台，对整个小鼠大脑中的个体大脑连接进行成像，从而在全球范围内绘制动物和人类不同尺度的大脑连接图的当前方法之间建立桥梁。