Hippocampal Neural Correlates of Memory Enhancement Via Theta-Rhythmic Human Brain Stimulation Via Simultaneous TMS/fMRI

项目总结摘要 在theta频段(4-8-hz)振荡的神经活动被认为提供了一个时间框架 在海马体内对情景记忆进行编码，并协调与记忆相关的处理 分布式海马-皮质网络(HCN)。然而，之前试图描述功能性的 人类hcn theta带活动在依赖相关神经活动方面的作用有限 不能产生强有力的因果推断的记录方法。在之前的研究中，我的实验室已经 证明theta-Burst经颅磁刺激适用于HCN的皮质结节 与对照刺激相比，HCN记忆功能会产生持久的变化。这个项目的总体目标是 拟议的项目是建立在这些先前发现的基础上，通过获得theta-Burst影响的神经关联 对HCN记忆加工的刺激。这将为theta在人类HCN中的作用提供一个因果检验 内存处理。为了实现这一目标，我们将使用一种新的方法，即以网络为目标的theta- 在执行记忆任务的过程中，突发刺激与fMRI神经成像同时进行。我们 假设Theta-Burst刺激传递到HCN的皮质结节将调制海马区 内存处理。这种针对网络的theta-Burst刺激的效果将与两种 控制条件，一种涉及目标不同的网络(网络控制)，另一种涉及刺激 在非theta-Burst频率(频率控制)。此外，记忆任务将允许我们区分 刺激Theta-Burst对海马依赖记忆加工的影响与对控制任务的影响 不涉及内存处理。我们假设，HCN靶向的theta-Burst刺激将导致 在记忆处理过程中选择性地增强海马体的活动，并将增强记忆的形成 相对于各种控制条件。这项提议提供了在复杂的多方面的培训机会 方法实验设计和任务型fMRI分析。这些发现将为HCN记忆的理论提供信息 正在处理。此外，被破坏的HCN theta振荡与记忆障碍有关，并且 因此，这一发现可能会激励大脑刺激在治疗记忆障碍方面的新应用。

PROJECT SUMMARY ABSTRACT Neural activity oscillating at theta-band frequencies (4-8-Hz) is thought to provide a temporal framework for episodic memory encoding within the hippocampus and to coordinate memory-related processing across a distributed hippocampal-cortical network (HCN). However, previous attempts to characterize the functional role of HCN theta-band activity in humans have been limited in their reliance on correlational neural activity recording methods that do not yield strong causal inferences. In previous research, my laboratory has demonstrated that theta-burst transcranial magnetic stimulation applied to cortical nodes of the HCN generates lasting changes in HCN memory function, relative to control stimulation. The overall goal of this proposed project is build on these previous findings by obtaining neural correlates of the impact of theta-burst stimulation on HCN memory processing. This will provide a causal test of the role of theta in human HCN memory processing. To accomplish this goal, we will use a novel method whereby network-targeted theta- burst stimulation is delivered concurrently with fMRI neuroimaging during performance of a memory task. We hypothesize that theta-burst stimulation delivered to a cortical node of the HCN will modulate hippocampal memory processing. The effects of this network-targeted theta-burst stimulation will be compared to two control conditions, one involving targeting a different network (network control) and one involving stimulation at a non-theta-burst frequency (frequency control). Furthermore, the memory task will allow us to distinguish effects of theta-burst stimulation on hippocampal-dependent memory processing versus on a control task that does not involve memory processing. We hypothesize that HCN-targeted theta-burst stimulation will cause greater hippocampal activity selectively during memory processing and will enhance memory formation relative to the various control conditions. This proposal offers training opportunities in sophisticated multi- method experimental designs and task-based fMRI analyses. Findings will inform theories of HCN memory processing. Furthermore, disrupted HCN theta oscillations have been implicated in memory disorders, and findings could therefore motivate new therapeutic applications of brain stimulation for memory impairments.