ShEEP Request for Multi-Modal Brain Imaging System

ShEEP 请求多模式脑成像系统

• 批准号: 9907326
• 负责人: Juliana V. Baldo
• 金额: --
• 依托单位: VA NORTHERN CALIFORNIA HEALTH CARE SYS
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2020-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9907326
• 关键词: Acute; Acute Brain Injuries; Adult; Aging; Alzheimer' s Disease; Area; Arousal; Automobile Driving; Basic Science; Beds; Behavioral; Biological Markers; Blood flow; Brain; Brain Diseases; Brain Injuries; Brain imaging; California; Claustrophobias; Clinical Treatment; Cognition; Collaborations; Country; Data; Data Storage and Retrieval; Dementia; Disease; Distant; Electrocardiogram; Electrodes; Electroencephalography; Electromyography; Electrooculography; Electrophysiology (science); Equipment; Excision; Funding; Galvanic Skin Response; Goals; Grant; Health Services Accessibility; Healthcare Systems; Heart Rate; Home environment; Hybrids; Image; Imaging Device; Individual; International; Intervention; Intervention Studies; Knowledge; Language; Left; Light; Location; Magnetic Resonance Imaging; Measurement; Measures; Memory; Methods; Mindfulness Training; Monitor; Morphologic artifacts; Motion; Movement Disorders; Muscle; Near-Infrared Spectroscopy; Neurophysiology - biologic function; Neuropsychological Tests; Neurosciences Research; Noise; Pacemakers; Participant; Patients; Performance; Peripheral; Personal Satisfaction; Physiological; Population; Positioning Attribute; Post-Traumatic Stress Disorders; Principal Investigator; Process; Quality of life; Randomized Controlled Trials; Recording of previous events; Recovery; Research; Research Activity; Resolution; Respiration; Risk; Rural; Rural Population; Safety; Scalp structure; Seminal; Sheep; Signal Transduction; Stress; Stroke; Structure; System; Task Performances; Technology; Testing; Time; Training; Translational Research; Traumatic Brain Injury; United States; United States National Institutes of Health; Veterans; Well in self; Wireless Technology; Work; acute stroke; aging brain; biological adaptation to stress; brain research; chronic pain; clinical diagnostics; cognitive change; cognitive function; computerized; design; disability; executive function; hemodynamics; imaging approach; imaging biomarker; imaging system; improved; mindfulness; mindfulness intervention; multimodality; neurofeedback; neuromechanism; outreach; portability; post stroke; programs; recruit; relating to nervous system; remote location; response; rural setting; sensor; stroke patient; stroke recovery; temporal measurement; tool; volunteer

Our VA Northern California Health Care System (VANCHCS) serves over 500,000 Veterans and is one of the largest catchments in the country, including a large rural component. Our Neuroscience Research Center on the VANCHCS Martinez campus has a 30-year history of groundbreaking Brain Injury Research in the area of basic brain research on stroke and traumatic brain injury (TBI). In the last several years, our research focus has grown to include translational and intervention research, such as studies on the efficacy of mindfulness, goal-training, and stress-inoculation training in individuals with a history of brain injury and post-traumatic stress disorder (PTSD). To further enhance our research with Veteran patients, we are requesting funds for a portable Multi-Modal Brain Imaging System that combines dry EEG and functional near-infrared spectroscopy (fNIRS). This system would allow us to collect synchronized electrophysiological and hemodynamic response data from aging and brain-injured patients with a comfortable, simple-to-use portable headset. The system also includes sensors to integrate physiological biomarkers such as heart rate, galvanic skin response (GSR), and respiration rate. Due to its design, recordings can be made while research patients are engaged in behavioral tasks, such as ambulation or operating a driving simulator. Importantly, this portable Imaging System would enable us to collect functional brain imaging and biomarker data from patients who are typically left out of brain research activities, such as Veterans in distant rural settings, bed-bound/home-bound patients (e.g., acute/post-acute stroke patients), and patients with MRI contraindications (e.g., claustrophobia, pacemakers, etc.). This additional functional brain imaging tool would strongly enhance our current neuroscience research program and increase our ability to apply for competitive grant funding. Currently, our Neuroscience Research group has several VA- and NIH-funded studies that would benefit from this brain imaging tool: 1) impact of stroke on driving performance; 2) randomized controlled trials of mindfulness training; 3) recovery of ambulation post-stroke; 4) executive functioning in TBI/PTSD; 5) longitudinal stroke recovery; and 6) computerized neuropsychological testing in presymptomatic Alzheimer’s Disease. Ultimately, our goal is to work towards improved clinical diagnostics and treatment interventions for our Veteran patients with brain injuries and related disorders.

我们的VA北方加州医疗保健系统（VANCHCS）为50多万退伍军人提供服务，是美国最大的退伍军人医疗保健系统之一。 这是该国最大的集水区，包括一个大的农村组成部分。神经科学研究中心 VANCHCS Martinez校区在脑损伤领域有着30年的开创性研究历史， 中风和创伤性脑损伤（TBI）的基础脑研究。近年来，我们的研究重点 已经发展到包括转化和干预研究，如对正念的功效的研究， 目标训练和压力接种训练，在有脑损伤和创伤后病史的个体中， 应激障碍（PTSD）。为了进一步加强我们对退伍军人患者的研究，我们正在申请资金， 结合干EEG和功能性近红外的便携式多模态脑成像系统 光谱法（fNIRS）。这个系统可以让我们收集同步的电生理和 老年和脑损伤患者使用舒适、简单易用便携式 耳机该系统还包括传感器，以整合生理生物标志物，例如心率、电流、心率、心率和心率。 皮肤反应（GSR）和呼吸率。由于其设计，可以在研究时进行录音 患者从事行为任务，例如Ambassador或操作驾驶模拟器。重要的是， 这种便携式成像系统将使我们能够收集功能性大脑成像和生物标记数据， 通常被排除在大脑研究活动之外的患者，如偏远农村的退伍军人， 卧床/居家的患者（例如，急性/急性卒中后患者）和MRI患者 禁忌症（例如，幽闭恐怖症、起搏器等）。这个额外的大脑功能成像工具 将大大加强我们目前的神经科学研究计划，并提高我们申请的能力， 竞争性资助。目前，我们的神经科学研究小组有几个VA和NIH资助的 将受益于这种大脑成像工具的研究：1）中风对驾驶性能的影响; 2） 正念训练的随机对照试验; 3）中风后Ambassador的恢复; 4）执行 功能在TBI/PTSD; 5）纵向中风恢复;和6）计算机神经心理学测试， 老年痴呆症的症状最终，我们的目标是努力改善临床 为我们的退伍军人脑损伤和相关疾病患者提供诊断和治疗干预。