角膜神经修复机制-猫眼课题宝

角膜神经修复机制

批准号：

9910407

负责人：

Mark I Rosenblatt

金额：

$40.08万

依托单位：

UNIVERSITY OF ILLINOIS AT CHICAGO

依托单位国家：

美国

项目类别：

财政年份：

2017

资助国家：

美国

项目状态：

已结题

起止时间：

2017-05-01 至 2022-04-30

来源：

https://reporter.nih.gov/project-details/9910407

关键词：

Affect Anatomy Angiogenic Factor Animal Model Binding Biological Assay Blindness Blinking Blood Vessels Cataract Extraction Cell Line Cells Chemical Injury Cornea Corneal Abrasion Corneal Diseases Corneal Injury Corneal Neovascularization Cultured Cells Cytometry Data Debridement Defect Development Diabetes Mellitus Dry Eye Syndromes Electrophysiology (science)Endothelial Cells Endothelial Growth Factors Receptor Epithelial Epithelium Esthesia Eye diseases Growth Growth Factor Hair Health Heterodimerization Homo Human Human body Image Immunoprecipitation In Vitro Individual Infection Injury KDR gene Keratopathy Knock-out Laceration Lamellar Keratoplasty Laser In Situ Keratomileusis Lead Ligands Mediating Mediator of activation protein Modeling Molecular Morphology Mus Nerve Nerve Degeneration Nerve Plexus Nerve Regeneration Neurons Neurotrophic Keratitis Notch Signaling Pathway Operative Surgical Procedures PIK3CG gene Pathway interactions Pattern Penetrating Keratoplasty Perforation Peripheral Peripheral Nerves Phosphorylation Physiological Population Receptor Activation Role Sensory Signal Pathway Site Stress Structure Structure of trigeminal ganglion Techniques Tissues Trauma Trigeminal nerve structure Tyrosine VEGFA gene Vascular Endothelial Growth Factor B Vascular Endothelial Growth Factors Western Blotting angiogenesis arm corneal regeneration corneal repair corneal surgery eye dryness ganglion cell in vivo inhibitor/antagonist knock-down melting nerve injury nerve supply neurogenesis neuronal survival neutralizing antibody prevent receptor repaired response restoration small hairpin RNA synergism wound

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英文摘要

PROJECT SUMMARY The cornea is the most densely innervated tissue in humans. Peripheral corneal nerves regenerate follow injury. Our hypothesis is that VEGF is a critical determinant of corneal nerve regeneration after injury and that the signaling pathways which mediate neurogenesis are distinct from those which mediate angiogenesis. Aim 1 will characterize the mechanisms by which VEGF ligands mediate corneal nerve repair in vitro and in vivo. Aim 2 characterizes the ability of VEGF ligands to mediate repair in animal models of corneal injury.

期刊论文(2)

专著(0)

科研奖励(0)

会议论文

Corneal lymphangiogenesis as a potential target in dry eye disease - a systematic review.

DOI： 10.1016/j.survophthal.2021.03.007

发表时间： 2021-11

期刊：

SURVEY OF OPHTHALMOLOGY

影响因子： 5.1

作者：

[Chennakesavalu, Mohansrinivas, Somala, Sri Raghurama R., Dommaraju, Sunil R., Peesapati, Meghna Priyanka, Guo, Kai, Rosenblatt, Mark I., Chang, Jin-Hong, Azar, Dimitri T.]

通讯作者： Azar, Dimitri T.