Mechanisms of Corneal Nerve Repair

角膜神经修复机制

• 批准号: 9910407
• 负责人: Mark I Rosenblatt
• 金额: $ 40.08万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-01 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9910407
• 关键词: Affect; Anatomy; Angiogenic Factor; Animal Model; Binding; Biological Assay; Blindness; Blinking; Blood Vessels; Cataract Extraction; Cell Line; Cells; Chemical Injury; Cornea; Corneal Abrasion; Corneal Diseases; Corneal Injury; Corneal Neovascularization; Cultured Cells; Cytometry; Data; Debridement; Defect; Development; Diabetes Mellitus; Dry Eye Syndromes; Electrophysiology (science); Endothelial Cells; Endothelial Growth Factors Receptor; Epithelial; Epithelium; Esthesia; Eye diseases; Growth; Growth Factor; Hair; Health; Heterodimerization; Homo; Human; Human body; Image; Immunoprecipitation; In Vitro; Individual; Infection; Injury; KDR gene; Keratopathy; Knock-out; Laceration; Lamellar Keratoplasty; Laser In Situ Keratomileusis; Lead; Ligands; Mediating; Mediator of activation protein; Modeling; Molecular; Morphology; Mus; Nerve; Nerve Degeneration; Nerve Plexus; Nerve Regeneration; Neurons; Neurotrophic Keratitis; Notch Signaling Pathway; Operative Surgical Procedures; PIK3CG gene; Pathway interactions; Pattern; Penetrating Keratoplasty; Perforation; Peripheral; Peripheral Nerves; Phosphorylation; Physiological; Population; Receptor Activation; Role; Sensory; Signal Pathway; Site; Stress; Structure; Structure of trigeminal ganglion; Techniques; Tissues; Trauma; Trigeminal nerve structure; Tyrosine; VEGFA gene; Vascular Endothelial Growth Factor B; Vascular Endothelial Growth Factors; Western Blotting; angiogenesis; arm; corneal regeneration; corneal repair; corneal surgery; eye dryness; ganglion cell; in vivo; inhibitor/antagonist; knock-down; melting; nerve injury; nerve supply; neurogenesis; neuronal survival; neutralizing antibody; prevent; receptor; repaired; response; restoration; small hairpin RNA; synergism; wound

PROJECT SUMMARY The cornea is the most densely innervated tissue in humans. Peripheral corneal nerves regenerate follow injury. Our hypothesis is that VEGF is a critical determinant of corneal nerve regeneration after injury and that the signaling pathways which mediate neurogenesis are distinct from those which mediate angiogenesis. Aim 1 will characterize the mechanisms by which VEGF ligands mediate corneal nerve repair in vitro and in vivo. Aim 2 characterizes the ability of VEGF ligands to mediate repair in animal models of corneal injury.

项目摘要 角膜是人类神经支配最密集的组织。角膜周围神经再生 损伤我们的假设是VEGF是损伤后角膜神经再生的关键决定因素， 介导神经发生的信号通路不同于介导血管生成的信号通路。目的 1将表征VEGF配体在体外和体内介导角膜神经修复的机制。 目的2表征VEGF配体在角膜损伤动物模型中介导修复的能力。

项目成果

Corneal lymphangiogenesis as a potential target in dry eye disease - a systematic review.

• DOI: 10.1016/j.survophthal.2021.03.007
• 发表时间: 2021-11
• 期刊: SURVEY OF OPHTHALMOLOGY
• 影响因子: 5.1
• 作者: Chennakesavalu, Mohansrinivas;Somala, Sri Raghurama R.;Dommaraju, Sunil R.;Peesapati, Meghna Priyanka;Guo, Kai;Rosenblatt, Mark I.;Chang, Jin-Hong;Azar, Dimitri T.
• 通讯作者: Azar, Dimitri T.